Protein Alignment Mekk1 and PAK1

DIOPT Version :9

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_001122092.1
• Gene: PAK1 / 5058
• HGNCID: 8590
• Length: 553
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 138/524 - (26%)
• Similarity: 229/524 - (43%)
• Gaps: 114/524 - (21%)

  Fly  1082 LACDPQITQHLDDD----EFEALKQQMDRCISHVIGITSEPEKVAKKKASPR----------TRK 1132
            |..|.:.|.|:..|    ||..:.:|..|.:.     ||...|..:|| :|:          ::|
Human    77 LPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQ-----TSNITKSEQKK-NPQAVLDVLEFYNSKK 135

  Fly  1133 TSSPATSRSRT-PTRTPMSAGMVLN-------PNTPPLQ----------SPPYNKLLHPQFSLKE 1179
            ||:.....|.| .:....::...||       |..||:.          :||      |..:.:.
Human   136 TSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPP------PVIAPRP 194

  Fly  1180 DVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTP-----PTPASPGKSSLESTP---LALRQE 1236
            :.:.:.|:             ||....|    |.||     .:|.||.:::  :||   |....|
Human   195 EHTKSVYT-------------RSVIEPL----PVTPTRDVATSPISPTENN--TTPPDALTRNTE 240

  Fly  1237 RVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVN 1301
            :.:......|.::.:.||....:|..|.                ::.|..|||||..|.||||::
Human   241 KQKKKPKMSDEEILEKLRSIVSVGDPKK----------------KYTRFEKIGQGASGTVYTAMD 289

  Fly  1302 NNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTL 1366
            ..||:.:|:|::.:|....:.|  :..|:.::...|:.|:|.|....:..:||.:.||..:.|:|
Human   290 VATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL 352

  Fly  1367 ESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL-VDGSNSLKLGDFGSAVKI 1430
            ..:|..| .:.|........:.|..:..||.:.::|||||:.||.| :||  |:||.|||...:|
Human   353 TDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQI 414

  Fly  1431 QAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQI 1495
               |....:....|||..:|||||.|:   ..:|...||||:|.:.:||..|:.|:.. ::..:.
Human   415 ---TPEQSKRSTMVGTPYWMAPEVVTR---KAYGPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRA 472

  Fly  1496 MFKVGMGEKP--QAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQV 1558
            ::.:.....|  |.||.||....||::.||:.|.::|.:|.|||:            ..:|:.||
Human   473 LYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQ------------VRKLRFQV 525

  Fly  1559 RGSF 1562
            ..:|
Human   526 FSNF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	87/263 (33%)
		S_TKc	1282..1541	CDD:214567	87/261 (33%)
PAK1	NP_001122092.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77		138/524 (26%)
		Autoregulatory region	70..140		18/68 (26%)
		PBD	74..128	CDD:334253	15/56 (27%)
		GTPase-binding	75..105		8/27 (30%)
		Interaction with CRIPAK. /evidence=ECO:0000269|PubMed:16278681	132..270		32/178 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..198		8/44 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..251		9/41 (22%)
		STKc_PAK_I	262..517	CDD:270814	88/282 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910