Protein Alignment Mekk1 and Ask1

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Alignment Length: 1016
• Identity: 219/1016 - (21%)
• Similarity: 362/1016 - (35%)
• Gaps: 319/1016 - (31%)

  Fly   633 ENVL--------KSRGLAKSLA---FLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDVPR 686
            ||:|        ::..|..|.|   ||....|......|:. .:|.:.:...|.:||.   .||.
  Fly    88 ENILTYNDIDSKQTLSLKLSCANYLFLSYKRNAETNSCHLT-SQPNSGNNSKEPNAEG---RVPT 148

  Fly   687 LDPEISRE-QVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETRPVRPNPL 750
            |...:.|: |.||:::..:..|:              |||.           ||........|..
  Fly   149 LQWRLKRKLQDVEIQSKAHMREK--------------FLSD-----------MRTARDTYATNGA 188

  Fly   751 SLEQLMKELREGLTLALTHRERYQRHITTALVENEAELGSYISIL---NHYDATVRKTFEL---- 808
            .|:.::.|:|:.|.         ..|:.:..|     :.|::..|   ..|||.||...:|
  Fly   189 KLQSILHEMRKRLD---------DPHVLSGEV-----VHSFMCSLRDVQDYDAMVRLVNDLKNIP 239

  Fly   809 ----YLEYIDQLVLVAVP------EGNQKSVLE--------KEWMFTKLISPMIKGMHTLASQKF 855
                |:|..:...|.|..      :|:::..||        ||..|..::.             .
  Fly   240 NTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDMLC-------------L 291

  Fly   856 CGIISKLLRSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQ----------SLLTV 910
            ||.|.|              ::..:.|.|..|.....:||...:.  |.|          :||.:
  Fly   292 CGRIYK--------------DIFVESDYTDATSLAHAIKWYRQSF--EVQPNEYAGINLATLLVI 340

  Fly   911 ERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICS-----------DVKAAFKL--L 962
            |.:.      |..|            |..:| :....::.|..           ||...|::  |
  Fly   341 EGKE------FTNT------------EELQH-IGMTLNNLIGKKGSLSSLSEYWDVATFFEISVL 386

  Fly   963 QQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRLFE 1027
            ..|          ..:.:|...|:..::..:...|..:  ....::|:..|...|....:    |
  Fly   387 AND----------YAKAIQAAECMFKLKPPNWYLKSTI--GNISLIHRFRKKPEERQPPI----E 435

  Fly  1028 QKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQ----- 1087
            :::.                    :.||.|.:|      ..........:.|.||..:||
  Fly   436 EQVF--------------------QFWMDFFLE------ATNTEEVKNSIRFPILILEPQKIYMP 474

  Fly  1088 --ITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMS 1150
              :|.::|.||...  |.::.|::|.        |.|.||
  Fly   475 SYVTINMDADEKSI--QIVNICLAHA--------KNACKK------------------------- 504

  Fly  1151 AGMVLNPNTPPLQSPPYNKLLHPQFSLKEDVSGTS-YSPVDSSDYVDTPCQRSANGELRLLVPQT 1214
                                :|....:...:...| |...|...|:..   ...:.:.::..|.|
  Fly   505 --------------------IHDFLFVASKIKSVSLYKRDDRCAYLYV---HHNSDDFQIYFPST 546

  Fly  1215 PPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLN-SSDKVHIRARSV 1278
            .                  |:::..|.:..:..|            ||..:| |:|..:|.....
  Fly   547 E------------------RRQKFYDMILEMTAD------------QVVFVNLSNDDANIEYEYD 581

  Fly  1279 HFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIA------IQPGETRALKNVAEELKILEGIK 1337
            :...:|.:.:|:|.:|.||.|.:..|...:|:||:.      :||        :.||:|:...::
  Fly   582 YDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQP--------LHEEIKLHSQLR 638

  Fly  1338 HKNLVRYYGIEVHREELLIFMELCSEGTLESLVE-----LTGNLPEALTRRFTAQLLSGVSELHK 1397
            |:|:|||.|.........||||....|:|..|:|     |..|  |:....::.|:|.|:..||:
  Fly   639 HRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDN--ESTMAFYSKQILEGLKYLHE 701

  Fly  1398 HGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDG 1462
            ..|||||||..|:.:...|..:|:.|||::.::   ..:....:.:.||..||||||..: ...|
  Fly   702 QDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRL---ARINPMTETFTGTLQYMAPEVIDQ-GVRG 762

  Fly  1463 HGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEK-PQAPESLSQEGHDFIDHCLQHD 1526
            :|.||||||.||..||||:||.|:.:..|....|||||..:| |..||.||....:||..|....
  Fly   763 YGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAIS 827

  Fly  1527 PKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRNVA 1567
            ...|.:|.:|||..|.   :|:....:..:.:...|.|:::
  Fly   828 VMDRPSASQLLEDPFL---QDKPRKVRPALPINTEFGRSIS 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	68/343 (20%)
		STKc_MEKK4	1281..1542	CDD:270796	96/272 (35%)
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459
		MAP3K_TRAF_bd	74..445	CDD:463827	85/483 (18%)
		ASK_PH	457..560	CDD:465956	25/178 (14%)
		STKc_ASK	576..843	CDD:270794	97/280 (35%)
		HisK-N-like	948..1079	CDD:466452