Protein Alignment Mekk1 and MAP3K5

DIOPT Version :9

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_016866359.1
• Gene: MAP3K5 / 4217
• HGNCID: 6857
• Length: 1494
• Species: Homo sapiens
• Alignment Length: 971
• Identity: 225/971 - (23%)
• Similarity: 379/971 - (39%)
• Gaps: 254/971 - (26%)

  Fly   754 QLMKELRE-----GLTLALTHRERYQRHITTALVENEAELGSYISILNHYDA----------TVR 803
            :.::.|||     |.||...|..:.....||.|   :....:.|:::...||          .||
Human   220 EALQSLREACETVGATLETLHFGKLDFGETTVL---DRFYNADIAVVEMSDAFRQPSLFYHLGVR 281

  Fly   804 KTFELYLEYIDQLVLVAVPEGNQKS-------VLEKEWMFT-------KLISP----------MI 844
            ::|.:    .:.::|..  :.|..|       :.:|..|.|       .:|:|          .:
Human   282 ESFSM----ANNIILYC--DTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFM 340

  Fly   845 KGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQSLLT 909
            ||:..|....|    ..||..|...||.|.::|.:    .|....::..:..:|...|:.::|.|
Human   341 KGLTELMQPNF----ELLLGPICLPLVDRFIQLLK----VAQASSSQYFRESILNDIRKARNLYT 397

  Fly   910 VE---------RER--SIKVL-----FFAKTFCRDVETTDFHREHYE-------HDVANQQHDFI 951
            .:         |:|  :|:||     .......||::..|...:..|       .|:|:..|
Human   398 GKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHH--- 459

  Fly   952 CSDVK--AAFKLLQQ----------DVL--------QVRNKLTAIIEGVQKRCCL-SNMRDLDEQ 995
               ||  .||.|.::          |::        ||.:.:..::..:.|...| ||..|.:.:
Human   460 ---VKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESR 521

  Fly   996 DK---------------QAVLSRTREILHQGYKF--GFEYHKDVIRLFEQKIMDQKDS-----GA 1038
            |.               |:.::....:|..|::|  .||..|..::|  ..::.:|.:     ..
Human   522 DHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKL--SSLLGKKGNLEKLQSY 584

  Fly  1039 HTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQ 1103
            ..|...||....|...|..:....:..:...|.|..:.:...||
Human   585 WEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETIL--------------------- 628

  Fly  1104 MDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSPPY- 1167
               ...|.:.:|:| :.|||::...........||....|..|.|:   ::|.|.  .:..|.|
Human   629 ---IYKHFVKLTTE-QPVAKQELVDFWMDFLVEATKTDVTVVRFPV---LILEPT--KIYQPSYL 684

  Fly  1168 ---NKLLHPQFS----LKEDVSG--------TSYSPVDSSDYVDTPC-----QRSANGELRLLVP 1212
               |::.....|    |.:|..|        :|...|..|.:.:..|     ..|.:.::..
Human   685 SINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYF--- 746

  Fly  1213 QTPPTPASPGKSSLESTPLALRQ--ERVRDAVNRLDMDLEDGLRERRLIG-QVKSLNSSDKVHIR 1274
                           .|.|..::  |.|...........|:|..|..|:. ..:...:.|:|
Human   747 ---------------CTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRV--- 793

  Fly  1275 ARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHK 1339
                        .:|:|.:|.||...:.:....:|:|||..:  ::|..:.:.||:.:.:.:|||
Human   794 ------------VLGKGTYGIVYAGRDLSNQVRIAIKEIPER--DSRYSQPLHEEIALHKHLKHK 844

  Fly  1340 NLVRYYGIEVHREELLIFMELCSEGTLESLVE-----LTGNLPEALTRRFTAQLLSGVSELHKHG 1399
            |:|:|.|.......:.||||....|:|.:|:.     |..|  |.....:|.|:|.|:..||.:.
Human   845 NIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDN--EQTIGFYTKQILEGLKYLHDNQ 907

  Fly  1400 IVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHG 1464
            |||||||..|:.:...|..||:.|||::.::..   :....:.:.||..|||||:..| ...|:|
Human   908 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG---INPCTETFTGTLQYMAPEIIDK-GPRGYG 968

  Fly  1465 RAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGE-KPQAPESLSQEGHDFIDHCLQHDPK 1528
            :||||||:||.::|||:||.|:.:.......||||||.: .|:.|||:|.|...||..|.:.||.
Human   969 KAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPD 1033

  Fly  1529 RRLTAVELLEHNFCKYGRDECSSEQLQMQVR------GS---FRRNVA---------TSSS 1571
            :|..|.:||...|.|     .||::.:.|.:      ||   :.|:::         ||||
Human  1034 KRACANDLLVDEFLK-----VSSKKKKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSS 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	94/266 (35%)
		S_TKc	1282..1541	CDD:214567	94/264 (36%)
MAP3K5	XP_016866359.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1672
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940