DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and MAP3K4

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_005913.3	Gene:	MAP3K4 / 4216	HGNCID:	6856	Length:	1608	Species:	Homo sapiens

Alignment Length:	1737	Identity:	501/1737 - (28%)
Similarity:	775/1737 - (44%)	Gaps:	393/1737 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ETPPTPPIPPIPPIRLRREQSVEED-----VARVEYRVKQTPSRPVQMTRNRIGALEEDMPPEDE 111
            |.||.||.||.||     |...|.:     .||.|..:..:..:          :.|.|:....:
Human    24 EPPPPPPPPPPPP-----EPETESEPECCLAARQEGTLGDSACK----------SPESDLEDFSD 73

  Fly   112 LAAHYEAFGTTPPRTRLKIKNRDWERKQKVVNVTAS-ADLPASVGGTPKKTRTARSRVLRRNTMD 175
            .......:||:||.|..::|....:.::..|...|| ::|...:....:.......:.:..
Human    74 ETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVEN---- 134

  Fly   176 CALLNEMFVNDESKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPL- 239
                    |.:.|.:.:|::::.||.:||:.|.::..:.:....|.|..:.:.|  .:|...|.
Human   135 --------VEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP--DVDLNKPYL 189

  Fly   240 -----NSEAMAPIPLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPG 299
                 |::....:|:.|| :.....:|..|                     ||..|:
Human   190 SLGCSNAKLPVSVPMPIA-RPARQTSRTDC---------------------PADRLK-------- 224

  Fly   300 LGKRKDFHETFANLIKLGSVD-RQDAKLSQEEHT---WQTELKDLIWLELQAWQADRTVEQQDKY 360
                  |.||...|:||.||. ::|.:...:|:|   |.....:|||||||||.|.||:..||.:
Human   225 ------FFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFF 283

  Fly   361 LFEARQGVSDLLTHIINYK-----FQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSL 420
            |:.|||.:.|::..|:.:|     |        :.:...:|.:..|........|.....|..:.
Human   284 LYTARQAIPDIINEILTFKVDYGSF--------AFVRDRAGFNGTSVEGQCKATPGTKIVGYSTH 340

  Fly   421 YCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNITKQN 485
            :  :.:..|.::..:|:.::..||..||||||.||:...:..|.::.|..|::::|||.||||..
Human   341 H--EHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDL 403

  Fly   486 KLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASR 550
            ..||.|:|.:|.........|||..........|:......::.:..:..::||...|.....|.
Human   404 NQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISD 468

  Fly   551 KGVTPCHKVQFMLNDATHVPG---------ETSSSNESTSTEVSQWSSECSHSHMRKGSMHDINI 606
            ..|.   :::..::::..:..         ...|.::|.......||:|...|.      |.:
Human   469 PRVP---EIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSR------HCL-- 522

  Fly   607 FSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGA--- 668
                              |.:||.|::..||..||.|.:..||||.:.:|.:|.|||.|...
Human   523 ------------------TSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVE 569

  Fly   669 ----EDFDYESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPL 729
                .|..:.||...:....|..:.:.|...         | ||.::::|||:.|.|:.|..:.|
Human   570 FSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS---------W-EELKAMDLPSFEPAFLVLCRVLL 624

  Fly   730 QFMHEFLRMRLETRPV-RPNPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAELGSYIS 793
            ..:||.|::|||.||. .|:.||::||::|.:|.|...|..::.||..:...|.:.|....:
Human   625 NVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCN--- 686

  Fly   794 ILNHYDATVRKTFELYLEYIDQLV--LVAVPEGNQ--KSVLEKEWMFTKLISPMIKGMHTLASQK 854
             ::.::..:.|...:|.:|:...:  |..:|:.:.  |::||:||.|||.|:..|:|....|.:.
Human   687 -IDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKL 750

  Fly   855 FCGIISKLLRS----ISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERS 915
            ||.|...||:|    :...|.:...|.....|   |:..::|::..::.|.|..:.|....|||:
Human   751 FCDIAGMLLKSTGSFLEFGLQESCAEFWTSAD---DSSASDEIRRSVIEISRALKELFHEARERA 812

  Fly   916 IKVLFFAKTFCRDVE-TTDFH--------------REHYEHDVANQQH------DFICSDVKAAF 959
            .|.|.|||...:|:| ..:|.              :::.:..:...::      |.:..:.....
Human   813 SKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIIL 877

  Fly   960 KLL-----------QQDVL--------------------------------------------QV 969
            :||           ..|||                                            ||
Human   878 QLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQV 942

  Fly   970 RNKLTAI----------------IEGVQKRC------------------------C--LSNMRD- 991
            .|.|..:                |||:...|                        |  :||..|
Human   943 DNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDR 1007

  Fly   992 ------------LDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRL----FEQKIMDQKDSGAHT 1040
                        :||.:...:....||.:.|||.|||||||:|:||    |.|||.|:
Human  1008 VDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDK------- 1065

  Fly  1041 VDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMD 1105
                  .|::|:.||::|:.:||.|||.|||||:||.:|| .|.:|.....|.:|:|.:|:..|:
Human  1066 ------YISFARKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSLQALMN 1123

  Fly  1106 RCISHVIGITSEPEK---VAKKKASPRTRKT-----------------------SSPATSRSR-T 1143
            .||.||||....|..   :|..:.|||..|.                       |.|:.:||. :
Human  1124 ECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGS 1188

  Fly  1144 PTRTPMSAGMVLNPNTPPLQSPP-YNKLLHPQFSLKEDVSGTSY--------------------- 1186
            |.....:|...:..:.|   ||. .:.:|....|...|..|:|.
Human  1189 PAAAAAAAAAAVAASRP---SPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRH 1250

  Fly  1187 -SPVDSSDYVDTPCQRSANG-----ELRLLVPQTPPTPASPGK-SSLESTPLALRQERVRDAVNR 1244
             ||.:..|....|...|:..     |||.|:.|:..|.:..|. .:::.:.....::|.|:
Human  1251 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYRE---- 1311

  Fly  1245 LDMDLEDGLRERRLIGQV-KSLNSSDKV-HIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGEL 1307
                    :|.:.:|||| .:..|.|.| |:..|.|.|:|.||.|||:|::|||||.::.:||||
Human  1312 --------MRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGEL 1368

  Fly  1308 MAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVEL 1372
            ||||||..||.:.:.:|..|:||||.|||||.|||||:|:|:||||:.||||.|.|||||.:..|
Human  1369 MAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL 1433

  Fly  1373 TGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHT-TV 1436
              .|.|.:.|.::.|:...::.||:|||||||||.|||||. .|..:||||||.:||::.:. |:
Human  1434 --GLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLT-SSGLIKLGDFGCSVKLKNNAQTM 1495

  Fly  1437 PGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGM 1501
            |||:...:||.|||||||.|:...:||||||||||:||||:||.:|||||.:::.|||||:||||
Human  1496 PGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1560

  Fly  1502 GEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDE 1548
            |.||..||.||.||.||:.|||:.|||.|.||.:||:|:|.|...||
Human  1561 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDE 1607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	153/261 (59%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	153/259 (59%)
MAP3K4	NP_005913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136		26/138 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..478		6/51 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1190		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1231		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1274		5/29 (17%)
		STKc_MEKK4	1342..1601	CDD:270796	153/261 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1055
eggNOG	1	0.900	-	-		E1_KOG4645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31346
Inparanoid	1	1.050	663	1.000	Inparanoid score	I765
Isobase	1	0.950	-	0	Normalized mean entropy	S4833
OMA	1	1.010	-	-		QHG46651
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	1	1.000	-	-		FOG0002637
OrthoInspector	1	1.000	-	-		oto88378
orthoMCL	1	0.900	-	-		OOG6_104404
Panther	1	1.100	-	-	LDO	PTHR48016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1672
SonicParanoid	1	1.000	-	-		X2354
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820