DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MAP3K3

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_976226.1	Gene:	MAP3K3 / 4215	HGNCID:	6855	Length:	657	Species:	Homo sapiens

Alignment Length:	494	Identity:	149/494 - (30%)
Similarity:	237/494 - (47%)	Gaps:	89/494 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1086 PQITQHLD--------DDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSR 1142
            |:..||:.        :.|.|.:.:..::|   ::...|..|...........|...||:..:||
Human   214 PERQQHIARQGSYTSINSEGEFIPETSEQC---MLDPLSSAENSLSGSCQSLDRSADSPSFRKSR 275

  Fly  1143 TPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQFSLKE------DVSGTSYS-----PVDSSDYVD 1196
                  ||..          ||.|.|:   .::|.:|      .|.|.:|.     .|...||.|
Human   276 ------MSRA----------QSFPDNR---QEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSD 321

  Fly  1197 ----TPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERR 1257
                .|..|...|.|..|||              .|..|:...|.:..||..||..
Human   322 GRRTFPRIRRHQGNLFTLVP--------------SSRSLSTNGENMGLAVQYLDPR--------- 363

  Fly  1258 LIGQVKSLNSSDKVHIRARSV-------HFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAI 1315
              |:::|.:|.:.:.::.|:|       ...|.||..:|||.||:||...:.:||..:|.|::..
Human   364 --GRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQF 426

  Fly  1316 QPGETRALKNVAE---ELKILEGIKHKNLVRYYGIEVHREE--LLIFMELCSEGTLESLVELTGN 1375
            .|......|.|:.   |:::|:.::|:.:|:|||....|.|  |.||||....|:::..::..|.
Human   427 DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGA 491

  Fly  1376 LPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGEL 1440
            |.|::||::|.|:|.|:|.||.:.|||||||.||| |.|.:.::||||||::.::|........:
Human   492 LTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGM 555

  Fly  1441 QGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG-MGEK 1504
            :...||..:|:|||.   :.:|:||.||:||:||.||||.:.|.|||:::: ...:||:. ....
Human   556 RSVTGTPYWMSPEVI---SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTN 616

  Fly  1505 PQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK 1543
            ||.|..:|:.|.||:..... :.::|.:|.|||.|:|.:
Human   617 PQLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQ 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	101/266 (38%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	101/264 (38%)
MAP3K3	NP_976226.1	PB1_Mekk2_3	76..154	CDD:99726
MAP3K3	NP_976226.1	STKc_MEKK3_like	392..652	CDD:270795	101/265 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920