DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and MAP3K1

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_005912.1	Gene:	MAP3K1 / 4214	HGNCID:	6848	Length:	1512	Species:	Homo sapiens

Alignment Length:	1632	Identity:	330/1632 - (20%)
Similarity:	575/1632 - (35%)	Gaps:	460/1632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 DESKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPIPLR 250
            |..:|..::::|:..|...|....||    |:|..:|...:..|.::..........|:.| |..
Human    56 DWRRRQLRKVRSVELDQLPEQPLFLA----ASPPASSTSPSPEPADAAGSGTGFQPVAVPP-PHG 115

  Fly   251 IASK----VVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFA 311
            .||:    :.||      |::...|  :|:|..|...:..|........|.|. |:..:..||..
Human   116 AASRGGAHLTES------VAAPDSG--ASSPAAAEPGEKRAPAAEPSPAAAPA-GREMENKETLK 171

  Fly   312 NLIKLGSVDRQDAKLSQEE------HTWQTELKDLIWL---------------------ELQAWQ 349
            .|.|:.  ||.:.::.:|:      ..|:.|     ||                     |:....
Human   172 GLHKMD--DRPEERMIREKLKATCMPAWKHE-----WLERRNRRGPVVVKPIPVKGDGSEMNHLA 229

  Fly   350 ADRTVEQQDKYLFEARQGVSDLLTHIINYKFQPRYRREPSLISLDSGTHSDSNS-----NASSPL 409
            |:...|.|......|.:|                 ||.||..:..||....|.|     ...||:
Human   230 AESPGEVQASAASPASKG-----------------RRSPSPGNSPSGRTVKSESPGVRRKRVSPV 277

  Fly   410 PSKM----------CQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYK 464
            |.:.          .....|.|     ..:|...|..:.|..||...:.:.|:|..:|...|..|
Human   278 PFQSGRITPPRRAPSPDGFSPY-----SPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNK 337

  Fly   465 SQSFVGRIKSMC-------------------------LWYNITKQNKLKLSILGKILARLQD--- 501
            .:.|:|.....|                         ||....|..::: |:..|..:|...
Human   338 YRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVE-SLFQKYHSRRSSRIK 401

  Fly   502 -------EKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKGVTPCHKV 559
                   :||...:..|..:::.|.|:|:|    ::|..:..:...|..:.|....:.:|.|
Human   402 APSRNTIQKFVSRMSNSHTLSSSSTSTSSS----ENSIKDEEEQMCPICLLGMLDEESLTVC--- 459

  Fly   560 QFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSH--------MRKGSMHDINIFSVE---PLG 613
                        |....|:.....:|.|:.||..:.        ..|...||  .:|.|   |:.
Human   460 ------------EDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHD--FYSHELSSPVD 510

  Fly   614 TCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALY------KAHIALEKPGAEDFD 672
            :.||....:|.|          ::.:.||.|........|:..|      .|:..|.:|..:.|.
Human   511 SPSSLRAAQQQT----------VQQQPLAGSRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFG 565

  Fly   673 YE------SDAESIEE-DVPRLDPEISREQVV--------------ELRTYGYWSEEAQS----- 711
            .|      |...::.| .:.||..::|...::              ...:.|..|..:|:
Human   566 MELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISGD 630

  Fly   712 --------INLPSYIPTF-VFLSGI----------PLQFMHEFLRMRLETRPV------------ 745
                    :::....|.: |:::.:          |...:.|.::::...:||
Human   631 VVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTILVKCADAN 695

  Fly   746 -RPNPLSLEQLMKELREGLTLAL-THRERYQR---------HITTALVENEAELGSYISILNHYD 799
             |.:.||:..|: ||.:|....| ..||..:.         ::...::.|:.|..::..:|....
Human   696 SRTSQLSISTLL-ELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLC 759

  Fly   800 ATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLISPMIKGMHTL-ASQKFCGIISKLL 863
            ...|...|...|:...:|...|.:.....:     .:.||:|.:...:.:: .|....|.:|:.:
Human   760 LIDRLLLEFPAEFYPHIVSTDVSQAEPVEI-----RYKKLLSLLTFALQSIDNSHSMVGKLSRRI 819

  Fly   864 RSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERSIKVLFFAKTFCRD 928
            ...|.|:|.....:..::             .::|::...|.  .|..|.|.:.:       ..:
Human   820 YLSSARMVTTVPHVFSKL-------------LEMLSVSSSTH--FTRMRRRLMAI-------ADE 862

  Fly   929 VETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRN----KLTAIIEGVQKRCCLSNM 989
            ||..:..:...|..:..||..|:.:.|       ..:.|:...    :.|..:|...|..|.:.:
Human   863 VEIAEAIQLGVEDTLDGQQDSFLQASV-------PNNYLETTENSSPECTVHLEKTGKGLCATKL 920

  Fly   990 ----RDLDEQ---------DKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTV 1041
                .|:.|:         ......:.|.|                    :.|.|.|.....|
Human   921 SASSEDISERLASISVGPSSSTTTTTTTTE--------------------QPKPMVQTKGRPH-- 963

  Fly  1042 DLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDR 1106
                                            ||.|....|:...|:.       |.||......
Human   964 --------------------------------SQCLNSSPLSHHSQLM-------FPALSTPSSS 989

  Fly  1107 CISHVIGITSEPEKVAKKK-----------ASPRT-RKTS----------------SPATSRSRT 1143
            ..|...|..::   |:|.:           |||:| ||.|                ||..::||
Human   990 TPSVPAGTATD---VSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPVFTQSR- 1050

  Fly  1144 PTRTPMSAGMVLNP--------NTPPLQSPPYNKL-LHPQFSLKED-----VSGTSYSPVDSSDY 1194
                |:.:..:..|        ||.....|..|.: |....|.|.|     .|.:|.:.:.|.:.
Human  1051 ----PLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNSSNAVIPSDET 1111

  Fly  1195 VDTP----CQRSANGELR-----LL---VPQTPPTPASPGKSSLESTPLALRQERVRDAVN---- 1243
            |.||    |:...|.||.     ||   :|.:..|.....:.::.|...|...:..:|.||
Human  1112 VFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQK 1176

  Fly  1244 ---RLDMDLEDGLR----------ERRLIGQVKSLNSSDKV------------HIRARSVH---F 1280
               :::.:.|:.|.          ...::.|::..|..|.:            |.:|:..:   .
Human  1177 CKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDT 1241

  Fly  1281 RWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIA----IQPGETRALKNVAEELKILEGIKHKNL 1341
            .|.:|.:||.|.|...|.|.:..||.|||:|::.    ....:...::.:.||::::..:.|.|:
Human  1242 EWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 1306

  Fly  1342 VRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIK 1406
            :|..|....:....:|:|..:.|::..|:...|...|::...:|.|||.|:|.||::.|:|||:|
Human  1307 IRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVK 1371

  Fly  1407 TANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQG-YVGTQAYMAPEVFTKTNSDGHGRAADIW 1470
            .||:.:......|::.|||:|.::.:..|..||.|| .:||.|:|||||.   ....:||:.|:|
Human  1372 GANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL---RGQQYGRSCDVW 1433

  Fly  1471 SVGCVVVEMASGKRPW-AQFDSN-FQIMFKVGMG-EKPQAPESLSQEGHDFIDHCLQHDPKRRLT 1532
            ||||.::|||..|.|| |:..|| ..::||:... ..|..|..||....|....||:..|:.|..
Human  1434 SVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPP 1498

  Fly  1533 AVELLEH 1539
            :.|||:|
Human  1499 SRELLKH 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	91/267 (34%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	91/266 (34%)
MAP3K1	NP_005912.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..181		31/129 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..304		19/112 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..436		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..532		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..624		2/21 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..972		9/92 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1087		11/59 (19%)
		STKc_MEKK1	1242..1509	CDD:270800	91/267 (34%)
		S_TKc	1243..1508	CDD:214567	91/266 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910