DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mekk1 and pak1

DIOPT Version :10

Sequence 1:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster
Sequence 2:XP_021323273.1 Gene:pak1 / 373103 ZFINID:ZDB-GENE-030826-29 Length:587 Species:Danio rerio


Alignment Length:613 Identity:149/613 - (24%)
Similarity:253/613 - (41%) Gaps:133/613 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   969 VRNKLTAIIEGVQKRCCLSNMRDLDE-QDKQAVLSRTREILHQGYKFGFEYHKDVIRLFE----- 1027
            |..:.|.:.|...:....||:..|:: ::.||||                   ||::.::     
Zfish    91 VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVL-------------------DVLKFYDSKETS 136

  Fly  1028 --QKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQ 1090
              ||.|...|.|....:.:..::                     |:..|:         .|.:..
Zfish   137 NNQKYMSFTDKGVENFNSSSAVV---------------------PKTVSE---------TPAVAT 171

  Fly  1091 HLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVL 1155
            ..:|::.|                  |.|.......:||...|.|..| ||            |:
Zfish   172 VSEDEDEE------------------EDEATPPPVIAPRPEHTKSIYT-RS------------VI 205

  Fly  1156 NPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPAS 1220
            .|..|||.:.  :....|..:...|...:|.:|..:::..:|....:.|      ...|..|.|:
Zfish   206 EPLPPPLSTK--DAATSPITNAAADGGSSSNAPSSNTNTTNTNTTNTTN------TTNTTSTSAA 262

  Fly  1221 PGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLI-----GQVKSLNSSDKVHIRARSVHF 1280
             ..::..|||      :..|...:..|..|:.|.:..::     |.:.|:....|.:.|..    
Zfish   263 -SSTNAPSTP------QTTDKSRKKKMSDEEILEKLNVLRSPSAGSIVSVGDPKKKYTRFE---- 316

  Fly  1281 RWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYY 1345
                  |||||..|.||||::..||:.:|:|::.:|....:.|  :..|:.::...|:.|:|.|.
Zfish   317 ------KIGQGASGTVYTAIDIATGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYL 373

  Fly  1346 GIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANI 1410
            ...:..:||.:.||..:.|:|..:|..| .:.||.......:.|..:..||.:.::|||||:.||
Zfish   374 DSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHCNQVIHRDIKSDNI 437

  Fly  1411 FL-VDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGC 1474
            .| :||  |:||.|||...:|   |....:....|||..:|||||.|:   ..:|...||||:|.
Zfish   438 LLGMDG--SVKLTDFGFCAQI---TPEQSKRSTMVGTPYWMAPEVVTR---KAYGPKVDIWSLGI 494

  Fly  1475 VVVEMASGKRPWAQFDSNFQIMFKVGMGEKP--QAPESLSQEGHDFIDHCLQHDPKRRLTAVELL 1537
            :.:||..|:.|:.. ::..:.::.:.....|  |.||.||....||::.||:.|.::|.:|.|||
Zfish   495 MAIEMIEGEPPYLN-ENPLRALYLIATNGTPELQNPEKLSAVFRDFLNRCLEMDVEKRGSAKELL 558

  Fly  1538 EHNFCKYGRDECSSEQLQMQVRGSFRRN 1565
            :|.|.|..:...|...|.:..:.:.:.|
Zfish   559 QHQFLKVAKPLSSLTPLIIAAKEAAKNN 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mekk1NP_732373.1 MEKK4_N 105..>930 CDD:466077
STKc_MEKK4 1281..1542 CDD:270796 88/263 (33%)
pak1XP_021323273.1 PBD 73..130 CDD:395634 12/57 (21%)
Protein Kinases, catalytic domain 283..586 CDD:473864 98/324 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.