Protein Alignment Mekk1 and map3k4

DIOPT Version :9

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_009305769.1
• Gene: map3k4 / 325488
• ZFINID: ZDB-GENE-990603-4
• Length: 1540
• Species: Danio rerio
• Alignment Length: 1744
• Identity: 503/1744 - (28%)
• Similarity: 763/1744 - (43%)
• Gaps: 465/1744 - (26%)

  Fly    63 PPIRLRREQSVEEDVARVEYRVKQTPSRPVQMTRNRIGALEE--DMPPEDELAAHYEAFGTTPPR 125
            ||..:|.:.|.::|                   ..:|..::|  |.|.::|    ...:.|:||:
Zfish     3 PPDEIRLKDSSKDD-------------------HQQITEVDESWDEPGQEE----ETLYCTSPPQ 44

  Fly   126 TRLKIKNRDWERKQKVVNVTASADLPASVGGTPKKTRTARSRVLRRNTMDCALLNEMFVNDESKR 190
            |..:||.         :::......|.|.|    |.::..|..|.:...:.|...|. ..:.|.:
Zfish    45 TPRQIKR---------LSIKHQRSNPGSKG----KEKSCSSSPLSQREREGARSAEP-PEEHSYK 95

  Fly   191 TDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAP--------- 246
            .:|:.:...|.|||::|...              |.|..|:.:.:...:.|..|.|
Zfish    96 QEKKQRFNQRSSERDVKKKF--------------EGAFMLDPVSKSSTIGSRNMDPRKPYLSLGM 146

  Fly   247 IPLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFA 311
            ||:|...:.    :|..|                     ||..|:              |.||..
Zfish   147 IPVRTHRQT----SRTDC---------------------PADRLK--------------FFETLR 172

  Fly   312 NLIKLGSVDRQDAKLSQ---EEHTWQTELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSDLLT 373
            .|:||.|:..:..:..|   |...:..:..::||||||||.|.|:|..||.|||.|||.:.|:::
Zfish   173 LLLKLTSMSSKKKEKEQRGLENTAYMEQNNEVIWLELQAWHARRSVNDQDLYLFTARQHIPDIIS 237

  Fly   374 HIINYKFQPRYRREPSLISLDSGTH-SDSNS------------------------NASSPLPSKM 413
            .::::|..     ..||..|:||.. .:|||                        :|::|..|
Zfish   238 EVLHFKVD-----YSSLCGLESGASVEESNSCPGETNCMDDPFSFSTCSASWQEIDAAAPFSS-- 295

  Fly   414 CQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLW 478
                 .|.|::.:..|.:|..:|:.:::.||:.||||||.|.:...:..|.::.|.||::::|||
Zfish   296 -----GLECRNHLQRQRVAFDQVKRVMSLLESVEALYPSLQTLQKDYEKYAARDFQGRVQALCLW 355

  Fly   479 YNITKQNKLKLSILGKILARLQDEKFSWPV-------CTSSYIATDSGSSSASGVENDDSAVNSM 536
            .|||:....||.::|.:|......:..||:       |:..               |:|..|:..
Zfish   356 LNITQDLNQKLRVMGTVLGLRDLSRIGWPIFEIPSPRCSRG---------------NEDDEVDED 405

  Fly   537 DSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSHMRKGSM 601
            :|....:....                ||     ||..:.:|:||   ....|.||..:..:
Zfish   406 ESESTTTFTAE----------------ND-----GEERTLSEATS---DGEQSACSPPNFSR--- 443

  Fly   602 HDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIAL--- 663
                :.|.|.. ....|.|....|.:||.|::..||..||.|.:..||||.:.:|.:|..||
Zfish   444 ----LMSEEEF-LPRDNETCYCPTAIYRPFVDKALKQMGLRKLILRLHKLMDRSLQRARTALLSH 503

  Fly   664 ----EKPGAEDFDYE-SDAESIEEDVPRLDPEISR------EQVVELRTYGYWSEEAQSINLPSY 717
                |.|....:..: ||          ..||:||      |:..|.....:  :|...::|||:
Zfish   504 MPAQELPAVPGYSLQHSD----------YLPELSRHFSGPVEEEAESGRVSW--QELMDMDLPSF 556

  Fly   718 IPTFVFLSGIPLQFMHEFLRMRLETRPV-RPNPLSLEQLMKELREGLTLALTHRERYQRHITTAL 781
            .|.|:.|..:.|..:||.|::|||.||. .|:.||::||::|.:|.|...|..::.|| .:...:
Zfish   557 RPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQ-FMLRGV 620

  Fly   782 VENEAELGSYISILNHYDATVRKTFELYLEYIDQLV--LVAVPEGNQ--KSVLEKEWMFTKLISP 842
            |.:...|.:..:| :.::..:.|..|:|.:|:...:  |..:|:.:.  |::||:||.|||:|:|
Zfish   621 VTDHQGLQTNANI-DEFEEDLHKMLEVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKVITP 684

  Fly   843 MIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQIDG------TADTDDNEEVKWQLLTIC 901
            .|:|....:.:.||.|...||:|..|.|     :...|..|      ..::..::|::..::...
Zfish   685 YIRGGEAQSGKLFCDIAGMLLKSTGEFL-----DAGLQKSGNEFWECAEESTASDEIRRSVIETS 744

  Fly   902 RETQSLLTVERERSIKVLFFAKTFCRDVE-TTDF------------------------------- 934
            |..:.|....|||:.|.|.|||...:|:| ..:|
Zfish   745 RSLKELFHEARERASKALGFAKMLRKDLEIAAEFSLTSGVSSLLQALKNKNYVKVQIPGLEELQV 809

  Fly   935 ---------------------------------HREHY----EHDVANQQHDFICSD-------- 954
                                             ..|.|    :|.|.:...|...::
Zfish   810 FVPCDLTEQRLVILQLLNAAAGKDCSKDPDEIPENEGYLLMSKHGVGDSNADGAWAEWDGTVLKL 874

  Fly   955 -------------------------------------------------------VKAAFKLLQQ 964
                                                                   :..|.:.|:.
Zfish   875 VPQMETVDTLRAMKVDNLLLVVMQSAHLVTQRKAFQQSMEELLSLSREQTSSQPLIVCALEQLKN 939

  Fly   965 DVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRL---- 1025
            :.||:..|:...|:.|:.........:::|.:|..:....||.:.|||.|.|||||:|:||
Zfish   940 EALQLCIKINDAIDRVEYMFMSEFEAEVEEAEKATLQQYYREAMIQGYNFAFEYHKEVVRLMSGE 1004

  Fly  1026 FEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQ 1090
            |.::|.::             .||:|:.||:||:.:||.|||.|||||:||.:|| .|.:.....
Zfish  1005 FRRRIGER-------------YIAFARKWMNFVLTKCESGRGTRPRWATQGFDFL-QAIEAAFIS 1055

  Fly  1091 HLDDDEFEALKQQMDRCISHVIGITSEPEK---VAKKKASPRTRKT------------------- 1133
            .|.:|:|.:|:..|:.||.||||....|..   .|..:.|||..|.
Zfish  1056 ALPEDDFVSLQALMNECIGHVIGKPHSPVSSMYFAGPRNSPRPVKVPRCHSDPPNPYLFIPSTQA 1120

  Fly  1134 ------SSPATSRSRTPTRTPMSAGMVLNPNTP--------------------PLQSPPYNKLLH 1172
                  |.|...|::.....|...|...:.|.|                    .||.    |.|.
Zfish  1121 EGFSSRSLPCDLRTQLCVPGPRPTGEHGHANKPSNDIRVSTGHENDRLSSVAAELQF----KSLS 1181

  Fly  1173 PQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQER 1237
            ...|..||....||...|.|    :..:||  .|||..:.|:        |.:...:||    |.
Zfish  1182 RHSSPTEDREEPSYPKADPS----SSARRS--WELRNFISQS--------KDTARQSPL----EA 1228

  Fly  1238 VRDAVNRLDMDLEDGLRERRLIGQV-KSLNSSDKV-HIRARSVHFRWHRGIKIGQGRFGKVYTAV 1300
            ||.::...|......:|:|.:|||| .:..|.|.| |:..|.|.|:|.||.|||:|::|||||.:
Zfish  1229 VRRSIQTFDEKHYALMRQRNIIGQVCNTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCI 1293

  Fly  1301 NNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGT 1365
            |.:||||||||||..||.:.:.:|..|:||||.|||||.|||||:|:|:||||:.||||.|.|||
Zfish  1294 NVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGT 1358

  Fly  1366 LESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKI 1430
            ||.:..|  .|.|.:.|.::.|:.:.::.||:|||||||||.|||||. .|..:||||||.:||:
Zfish  1359 LEEVSRL--GLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFLT-SSGLIKLGDFGCSVKL 1420

  Fly  1431 QAHT-TVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQ 1494
            :.:. |:|||:...:||.|||||||.|:...:||||||||||:|||::||.:|||||.:::.|||
Zfish  1421 KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQ 1485

  Fly  1495 IMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDE 1548
            ||::||||.||..||.||.||.||:.|||:.:||||.||..||:|.|.|...||
Zfish  1486 IMYRVGMGHKPPIPEKLSTEGKDFLAHCLESEPKRRWTASALLDHPFVKVCTDE 1539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	152/261 (58%)
		S_TKc	1282..1541	CDD:214567	152/259 (59%)
map3k4	XP_009305769.1	STKc_MEKK4	1274..1533	CDD:270796	152/261 (58%)
		S_TKc	1275..1533	CDD:214567	152/260 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574253
Domainoid	1	1.000	336	1.000	Domainoid score	I1090
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31346
Inparanoid	1	1.050	652	1.000	Inparanoid score	I770
OMA	1	1.010	-	-		QHG46651
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	1	1.000	-	-		FOG0002637
OrthoInspector	1	1.000	-	-		oto41103
orthoMCL	1	0.900	-	-		OOG6_104404
Panther	1	1.100	-	-	LDO	PTHR48016
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2354
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910