DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and Stk4

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001101270.1	Gene:	Stk4 / 311622	RGDID:	1312035	Length:	487	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	85/260 - (32%)
Similarity:	135/260 - (51%)	Gaps:	15/260 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHR 1351
            |:|:|.:|.||.|::..||:::|:|::.::..    |:.:.:|:.|::.....::|:|||.....
  Rat    35 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESD----LQEIIKEISIMQQCDSPHVVKYYGSYFKN 95

  Fly  1352 EELLIFMELCSEGTLESLVELTG-NLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDG 1415
            .:|.|.||.|..|::..::.|.. .|.|..........|.|:..||....:|||||..|| |::.
  Rat    96 TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNI-LLNT 159

  Fly  1416 SNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMA 1480
            ....||.|||.|.::   |....:....:||..:|||||..:.   |:...|||||:|...:|||
  Rat   160 EGHAKLADFGVAGQL---TDTMAKRNTVIGTPFWMAPEVIQEI---GYNCVADIWSLGITAIEMA 218

  Fly  1481 SGKRPWAQFDSNFQIMFKVGMGEKP--QAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK 1543
            .||.|:|.... .:.:|.:.....|  :.||..|....||:..||...|::|.||.:||:|.|.|
  Rat   219 EGKPPYADIHP-MRAIFMIPTNPPPTFRKPEVWSDNFMDFVKQCLVKSPEQRATATQLLQHPFVK 282

Fly 1544 1543
Rat 283 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	83/257 (32%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	83/256 (32%)
Stk4	NP_001101270.1	STKc_MST1_2	26..281	CDD:132943	83/257 (32%)
Stk4	NP_001101270.1	Mst1_SARAH	433..480	CDD:402983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910