DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mekk1 and Map3k4

DIOPT Version :9

Sequence 1:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster
Sequence 2:XP_038966484.1 Gene:Map3k4 / 308106 RGDID:1311192 Length:1599 Species:Rattus norvegicus


Alignment Length:1742 Identity:509/1742 - (29%)
Similarity:772/1742 - (44%) Gaps:412/1742 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 ETPPTPPIPPIPPIRLRREQSVEEDVARVEYRVKQTPSRPVQMTRNRIGALEEDMPPED--ELAA 114
            |..|.||..|.|       :|.....||.|:.:.::..:          :||.|  |||  :...
  Rat    24 EPRPAPPPQPEP-------ESECCPAARQEHMLGESARK----------SLESD--PEDFSDETN 69

  Fly   115 HYEAFGTTPPRTRLKIKNRDWERKQKVVNVTASADLPASVGGTPKKTRT---ARSRVLRRNTMDC 176
            ....:||:||.|..::|....:.::.      ||..|||.....:|..|   :..:.|.:..   
  Rat    70 TENLYGTSPPSTPRQMKRLSAKHQRN------SAGRPASRANLKEKMNTPSQSPHKDLGKGV--- 125

  Fly   177 ALLNEMFVNDESKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNS 241
                 ..|.:.|.:..|:.::.||.:||:.|.:.              :.:..|:|:...:|..|
  Rat   126 -----EAVEEYSYKQGKKTRATLRTTERDHKKNA--------------QCSFMLDSVAGSLPKKS 171

  Fly   242 EAMAPIPLRIASKVVES--CNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRK 304
                 ||....:|...|  |:..:...|.|:       |:|..|:..:   |:|..|     .|.
  Rat   172 -----IPDVDLNKPYLSLGCSNAKLPVSMPM-------PIARTARQTS---RTDCPA-----DRL 216

  Fly   305 DFHETFANLIKLGSVD-RQDAKLSQEEHT---WQTELKDLIWLELQAWQADRTVEQQDKYLFEAR 365
            .|.||...|:||.||. ::|.:...:|:|   |.....:|||||||||.|.||:..||.:|:.||
  Rat   217 KFFETLRLLLKLTSVSKKKDREQRGQENTAAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTAR 281

  Fly   366 QGVSDLLTHIINYKFQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQ---GCMSLYCKDCMD 427
            |.:.|::..|:.:|           ::..|...|.:.:..:.......|:   |..||.|....:
  Rat   282 QAIPDIINEILTFK-----------VNYGSAAFSRNGAGFNGTSLEGQCRTLHGTNSLGCSTYHE 335

  Fly   428 H---QELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNITKQNKLKL 489
            |   |.::..:|:.::..||..||||||.||:...:..|.::.|..|::::|||.||||....||
  Rat   336 HLQRQRVSFEQVKRIMELLEYMEALYPSLQALQKDYERYAAKDFEDRVQALCLWLNITKDLNQKL 400

  Fly   490 SILGKILARLQDEKFSWPVC-------TSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGS 547
            .|:|.:|.........|||.       :..|...:.|..:...:...:|.....|..:.|:    
  Rat   401 RIMGTVLGIKNLSDIGWPVFEIPSPRPSKGYEPEEEGEDTEGELRELESGTEESDEERSPN---- 461

  Fly   548 ASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSHMRKGSMHDINIFSVEP- 611
                               ..||    ....|..|.:...|..|:...:.:       :.|.|. 
  Rat   462 -------------------PRVP----ELRLSADTILDSHSQGCASRKLER-------LESEEDS 496

  Fly   612 ----LGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGA---- 668
                :..|....:....|.:||.|::..||..||.|.:..||||.|.:|.:|.:||.|...    
  Rat   497 VGWGIADCGPEASRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMNGSLQRARVALVKDDRPVEF 561

  Fly   669 EDFD---YESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQ 730
            .||.   :.||...:....|..:.:.|...         | ||.::::|||:.|.|:.|..:.|.
  Rat   562 SDFPGPMWGSDYVQLSGTPPSSEQKCSAVS---------W-EELRAMDLPSFEPAFLVLCRVLLN 616

  Fly   731 FMHEFLRMRLETRPV-RPNPLSLEQLMKELREGLTLALTHRERYQ---RHITTALVENEAELGSY 791
            .:||.|::|||.||. .|:.||::||::|.:|.|...|..::.||   :.:...|.:.:..:.: 
  Rat   617 VIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLDGLEKTDCNMDA- 680

  Fly   792 ISILNHYDATVRKTFELYLEYIDQLV--LVAVPEGNQ--KSVLEKEWMFTKLISPMIKGMHTLAS 852
                  ::..::|...:|.:|:...:  |..:|:.:.  |::||:||.|||.|:..|:|....|.
  Rat   681 ------FEDDLQKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAG 739

  Fly   853 QKFCGIISKLLRS----ISERLVKRTVELDQQIDGTADTDDN---EEVKWQLLTICRETQSLLTV 910
            :.||.|...||:|    :...|.:...||      ....|||   :|::..::.|.|..:.|...
  Rat   740 KLFCDIAGMLLKSTGSFLDSGLQESCAEL------WISADDNGAADELRRSVIEISRALKELFHE 798

  Fly   911 ERERSIKVLFFAKTFCRD----------------------------------------------- 928
            .|||:.|.|.|||...:|                                               
  Rat   799 ARERASKALGFAKMLRKDLEIAAEFVLSASARELLDVLRAKQYVKVQIPGLENLHVFVPDSLAEE 863

  Fly   929 ----------------------------------------------------------VETTD-- 933
                                                                      |||.|  
  Rat   864 KKIILQLLNAATGKDCSKDPDDVFVDAFLLLTKHGDRARDSEDGWSTWEARAIKIVPQVETVDTL 928

  Fly   934 -------------------FHREHYEHDV---ANQQHDFICSD--VKAAFKLLQQDVLQVRNKLT 974
                               ..|:.::..:   ....|:...|.  :..|.:.|:.|.|::.|:::
  Rat   929 RSMQVDNLLLVVMESAHLVLQRKAFQQSIEGLMTVHHEQTSSQPVIAKALQQLKNDALELCNRIS 993

  Fly   975 AIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRL----FEQKIMDQKD 1035
            ..|:.|.....|....:::|.:...:....||.:.|||.|||||||:|:||    |.|||.|:  
  Rat   994 DAIDRVDHMFTLELDAEVEESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDK-- 1056

  Fly  1036 SGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEAL 1100
                       .|::|:.||::|:.:||.|||.|||||:||.:|| .|.:|.....|.:|:|.:|
  Rat  1057 -----------YISFAQKWMNYVLTKCESGRGTRPRWATQGFDFL-QAIEPAFISALPEDDFLSL 1109

  Fly  1101 KQQMDRCISHVIG-----ITS------EPEKVAKKKASP-------------RTRKTSS------ 1135
            :..|:.||.||||     :|:      .|.||.:..:.|             .||...|      
  Rat  1110 QALMNECIGHVIGKPHSPVTAIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPSDTRNHG 1174

  Fly  1136 ---------PATSRSRTPTRTPMSAGMVLNPNTPPLQSP-------PYNKLLHPQFSLKEDVSGT 1184
                     .|.:.:.|....|...|....|..|...:|       |.|..|   .|:..::...
  Rat  1175 NSVAAAAVAAAAAAATTAAGRPGPGGGDSAPAKPVNTAPDTRGSSVPENDRL---ASIAAELQFR 1236

  Fly  1185 SY----SPVDSSDYVDTPCQRSANG-----ELRLLVPQTPPTPASPGK-SSLESTPLALRQERVR 1239
            |.    ||.:..|....|...|:..     |||.|:.||..:.:..|. .:::.:.....:.|.|
  Rat  1237 SLSRHSSPTEERDEPAYPRSDSSGSTRRSWELRTLISQTKDSASKQGPIEAIQKSVRLFEERRYR 1301

  Fly  1240 DAVNRLDMDLEDGLRERRLIGQV-KSLNSSDKV-HIRARSVHFRWHRGIKIGQGRFGKVYTAVNN 1302
            :            :|.:.:|||| .:..|.|.: |:..|.|.|:|.||.|||:|::|||||.::.
  Rat  1302 E------------MRRKNIIGQVCDTPKSYDNIMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISV 1354

  Fly  1303 NTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLE 1367
            :||||||||||..||.:.:.:|..|:||||.|||||.|||||:|:|:||||:.||||.|.|||||
  Rat  1355 DTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE 1419

  Fly  1368 SLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQA 1432
            .:..|  .|.|.:.|.::.|:...::.||:|||||||||.|||||. .|..:||||||.:||::.
  Rat  1420 EVSRL--GLQEHVIRLYSKQITVAINVLHEHGIVHRDIKGANIFLT-SSGLIKLGDFGCSVKLKN 1481

  Fly  1433 HT-TVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIM 1496
            :. |:|||:...:||.|||||||.|:...:||||||||||:||||:||.:|||||.:|:.|||||
  Rat  1482 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEFEHNFQIM 1546

  Fly  1497 FKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDE 1548
            :|||||.||..||.||.||.||:.|||:.|||.|.||.:||:|.|.|...||
  Rat  1547 YKVGMGHKPPIPERLSPEGKDFLSHCLESDPKIRWTASQLLDHAFVKVCTDE 1598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mekk1NP_732373.1 STKc_MEKK4 1281..1542 CDD:270796 154/261 (59%)
S_TKc 1282..1541 CDD:214567 154/259 (59%)
Map3k4XP_038966484.1 STKc_MEKK4 1333..1592 CDD:270796 154/261 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 336 1.000 Domainoid score I1086
eggNOG 1 0.900 - - E1_KOG4645
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31346
Inparanoid 1 1.050 654 1.000 Inparanoid score I746
OMA 1 1.010 - - QHG46651
OrthoDB 1 1.010 - - D55144at2759
OrthoFinder 1 1.000 - - FOG0002637
OrthoInspector 1 1.000 - - oto95520
orthoMCL 1 0.900 - - OOG6_104404
Panther 1 1.100 - - LDO PTHR48016
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2354
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.880

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