DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and Map3k3

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001100528.1	Gene:	Map3k3 / 303604	RGDID:	1304575	Length:	626	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	147/493 - (29%)
Similarity:	237/493 - (48%)	Gaps:	87/493 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1086 PQITQHLD--------DDEFEALKQQMDRCI-----SHVIGITSEPEKVAKKKASPRTRKTSSPA 1137
            |:..||:.        :.|.|.:.:..::|:     |....::...:.:.:...||..|| |..:
  Rat   183 PERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRK-SQMS 246

  Fly  1138 TSRSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYS-----PVDSSDYVD- 1196
            .:||....|...|          ..::..|:|          .|.|.:|.     .|...||.|
  Rat   247 RARSFPDNRKECS----------DRETQLYDK----------GVKGGTYPRRYHVSVHHKDYNDG 291

  Fly  1197 ---TPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRL 1258
               .|..|...|.|..|||              .|..|:...|.:..||..||..
  Rat   292 RRTFPRIRRHQGNLFTLVP--------------SSRSLSTNGENMGAAVQYLDPR---------- 332

  Fly  1259 IGQVKSLNSSDKVHIRARSV-------HFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQ 1316
             |:::|.:|.:.:.::.|||       ...|.||..:|||.||:||...:.:||..:|.|::...
  Rat   333 -GRLRSADSENALTVQERSVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFD 396

  Fly  1317 PGETRALKNVAE---ELKILEGIKHKNLVRYYGIEVHREE--LLIFMELCSEGTLESLVELTGNL 1376
            |......|.|:.   |:::|:.::|:.:|:|||....|.|  |.||||....|:::..::..|.|
  Rat   397 PDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGAL 461

  Fly  1377 PEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQ 1441
            .|::||::|.|:|.|:|.||.:.|||||||.||| |.|.:.::||||||::.::|........::
  Rat   462 TESVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGMR 525

  Fly  1442 GYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG-MGEKP 1505
            ...||..:|:|||.   :.:|:||.||:||:||.||||.:.|.|||:::: ...:||:. ....|
  Rat   526 SVTGTPYWMSPEVI---SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNP 586

  Fly  1506 QAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK 1543
            |.|..:|:.|.||:..... :.::|.:|.|||.|:|.:
  Rat   587 QLPSHISEHGRDFLRRIFV-EARQRPSAEELLTHHFAQ 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	101/266 (38%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	101/264 (38%)
Map3k3	NP_001100528.1	PB1_Mekk2_3	45..123	CDD:99726
Map3k3	NP_001100528.1	STKc_MEKK3_like	361..621	CDD:270795	101/265 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920