DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and Pak3

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_008771626.1	Gene:	Pak3 / 29433	RGDID:	3251	Length:	580	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	136/520 - (26%)
Similarity:	217/520 - (41%)	Gaps:	124/520 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1132 KTSSPAT-SRSRTPTRTPMSAGMVLNPNTPP----------LQSPPYNKL---LHPQ-------- 1174
            :||.|.| :.|::..:.|...|..:.|...|          ||:....||   .:||
  Rat    97 QTSRPVTVASSQSEGKLPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKF 161

  Fly  1175 FSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRL------------LVP--------------- 1212
            :..||.|:...|....|.|       :||:|.:..            |.|
  Rat   162 YDSKETVNNQKYMSFTSGD-------KSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEED 219

  Fly  1213 --QTPP----------------------TPASPGKSSLESTP----------LALRQERVRDAVN 1243
              :.||                      :||:|.|   |:||          |....:|.|....
  Rat   220 DNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNK---EATPPSAENANSSTLYRNTDRQRKKSK 281

  Fly  1244 RLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELM 1308
            ..|.::.:.||....:|..|.                ::.|..|||||..|.||||::..||:.:
  Rat   282 MTDEEILEKLRSIVSVGDPKK----------------KYTRFEKIGQGASGTVYTALDIATGQEV 330

  Fly  1309 AMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELT 1373
            |:|::.:|....:.|  :..|:.::...|:.|:|.|....:..:||.:.||..:.|:|..:|..|
  Rat   331 AIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET 393

  Fly  1374 GNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL-VDGSNSLKLGDFGSAVKIQAHTTVP 1437
             .:.|........:.|..:..||.:.::|||||:.||.| :||  |:||.|||...:|   |...
  Rat   394 -CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDG--SVKLTDFGFCAQI---TPEQ 452

  Fly  1438 GELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMG 1502
            .:....|||..:|||||.|:   ..:|...||||:|.:.:||..|:.|:.. ::..:.::.:...
  Rat   453 SKRSTMVGTPYWMAPEVVTR---KAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATN 513

  Fly  1503 EKP--QAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRN 1565
            ..|  |.||.||....||::.||:.|..||.:|.|||:|.|.|..:...|...|.:..:.:.:.:
  Rat   514 GTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAIKNS 578

Fly 1566 1565
Rat 579 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	89/263 (34%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	89/261 (34%)
Pak3	XP_008771626.1	PBD	69..162	CDD:395634	15/64 (23%)
Pak3	XP_008771626.1	STKc_PAK3	284..580	CDD:132987	98/323 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910