DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and Map3k19

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_038947212.1	Gene:	Map3k19 / 289001	RGDID:	1566400	Length:	1513	Species:	Rattus norvegicus

Alignment Length:	1515	Identity:	304/1515 - (20%)
Similarity:	518/1515 - (34%)	Gaps:	520/1515 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 LYCKDCMDHQ----------ELALREVEGMLTRLEAAEALYPSSQAMGAL---HPIYKSQSFVGR 471
            |.|::.:|..          .||:|:|: :...|:.: .:|..::.:..|   |...|...|.|:
  Rat   121 LACEEFLDINFPNSHGLTPLMLAVRDVD-LFESLDVS-TVYRPAEVLAELLRHHADPKLCDFSGK 183

  Fly   472 IKSMCLWYNITKQNKLKLSIL-----------GKILARLQDEKFSWP----VCTSSYIATDSGSS 521
             .:|.....|....|.:|.::           .:.|..:..|..|.|    |..:..|...|.||
  Rat   184 -SAMHYVSQINSWRKQQLLVILTDSMPKPERHAESLLDICHEAGSTPMDMTVSKTENITLQSISS 247

  Fly   522 SASGVENDDSAVNSMDSSKPPSMAGSASRKGVTP--------CHKVQFMLNDATHVPGETSSSNE 578
            |:|    :|.|::  |...|..:||    :|..|        ...|:.::  ....|.....:::
  Rat   248 SSS----EDFALD--DDFSPSILAG----EGTAPRGEGWPRRTEGVEILV--TMFPPDSPQEASQ 300

  Fly   579 STSTEVSQWSSECSHSHMRKGSMHDIN-IFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLA 642
            ...||.||.:||    ....|..|.:: ...||.:|..|...|.:.|          :||:.|.:
  Rat   301 EDLTESSQVTSE----RPEWGPGHPVSPAKEVEMVGLTSRMLTTQPS----------LLKTEGGS 351

  Fly   643 KSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDVP---RLDPEIS-REQVVELRTYG 703
            :.|.           .|.:||..| ....|..:...::.|:.|   ::.|..| :....::|
  Rat   352 QELC-----------GADVALSPP-RPCLDPSTAIAAVREEAPHVLKVQPRKSDKFPTSDMR--- 401

  Fly   704 YWSEEAQSINL--PSYIP--TFVFLSGIPLQFMHEFLRMRLETRPVRPN---------PLSLEQL 755
             :|.....:.|  ||.:|  :.||               .:|..|..|.         .||:.:|
  Rat   402 -YSSRRTELPLPPPSLLPMRSSVF---------------NMEKSPKFPRHGERKVPSLSLSVPKL 450

  Fly   756 MKELREGLT-----------------------------------LALTHRERYQRHIT------- 778
            ::.|.:.|:                                   |....:.|.||.:.
  Rat   451 LEPLSQPLSQSAEFSSAKNQQEVTWEGPPEHTLRGSDWAIWSRNLCSFRKSRKQRGVAESWRSQE 515

  Fly   779 ---------------------------TALVENEAELGSYISIL-----NHY----------DAT 801
                                       ||.:|.|.:.|.:||.:     :.|          |..
  Rat   516 TKGGDKTETSGFEEGPFLFSCGSVKEDTAPIERERDSGCHISEISGREDSQYLLSGEKESWTDRA 580

  Fly   802 VRKTFELYLEYIDQLVLVAVPEGNQKSVL--EKEWMFTKLISPMIKGMHTLASQKFCGIISKLLR 864
            |.|..|:...::.:|    :...|.|..|  |||....|:.......:|...:.:...::.:|
  Rat   581 VEKDLEVEHPFLSEL----LEASNTKITLAEEKEIGNEKVPDSESNSVHRAGTVQPHAVLEEL-- 639

  Fly   865 SISERLVKRTVE--LDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERS---------IKV 918
            |:.:.:.:...:  :...::|..||::|.:               |.:|.|.:         :.:
  Rat   640 SVPKNIPRMNSDGPITGLLEGHGDTEENRK---------------LPIEEETNPEMNGAVPLVHI 689

  Fly   919 LFFAKTFCRDVETTDFHREHYEHDV---------ANQQHDFICSDVKAAFKLLQQDVLQVRNK-- 972
            .|..:...:.......:.:..:|.|         |.|:|..:.::....         :.||:
  Rat   690 TFPGEGTPKGPARAKPNLQRRKHPVQSSGSPNILARQEHGKLQTNTHRT---------KARNRPP 745

  Fly   973 --LTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREIL-------HQGYKFGFEYHKDVIRLFEQ 1028
              |...|:...|    .|:|      |.::.::....|       |...||     :....:.|:
  Rat   746 PNLMVSIQASIK----PNVR------KNSIKTQVFPALEFMDHRPHPPSKF-----QRRAPVTEK 795

  Fly  1029 KIMDQ-------------KDSGAHTVDLALGI-----------IAYAKMWMHFVMERCERGRGM- 1068
            |.|.|             |::|.....:.|.:           :.|:.|:..  :.....|.|:
  Rat   796 KSMCQTQKPKKQAFPHICKNAGIKKPGVVLSVETTDPRLHFLDLKYSDMFKE--INSASNGPGIY 858

  Fly  1069 ---------------------------RPRWASQGLEFLILACDPQITQHLDDDEFE-------- 1098
                                       .|...|.|.:     |.|..:....:....
  Rat   859 EMFGTPVYSHIREAERHEHRHYHEICAAPSGRSVGNK-----CQPSQSDRCANSRARLLQKRPHV 918

  Fly  1099 -------ALKQQMDRCIS----------HVIGITSEP---------EKVAKKKASPRTRKTSSPA 1137
                   .|||:....||          ||....|||         :.::.|..:..|..|..|.
  Rat   919 KPPKPSLGLKQKHRGLISKDKGCKGMGGHVEDSVSEPGWQTRPSANDSLSSKDEAQLTHLTLIPE 983

  Fly  1138 TS--RSRTPTRTPMS-------------AGMV-----------------LNPNTPPLQS------ 1164
            ||  :..||..:.:|             .|::                 |:|.||.:.|
  Rat   984 TSPEQRETPPLSDLSIVEEIFTEECADEEGILHNDSLTQSLGDLKALEGLHPQTPLVPSEDSWAV 1048

  Fly  1165 ----------PPYNKLLHPQFSLKEDVSGTSYSPVDS-SDYVDTPCQRSANGELRLLVPQTPPTP 1218
                      .|....:.|...:..|...|.|...|| ||...|....|......  .|::.|:|
  Rat  1049 LSEKHSGKHVSPGKHDVGPLDKINADQMFTGYLEFDSLSDKSKTRVSFSRYSFQE--KPESAPSP 1111

  Fly  1219 A-------------------------------SPGKSS---------LESTPLALRQE------- 1236
            .                               .|||:.         |....||:.::
  Rat  1112 TEQPWAHSLDQDSLEDDSTTYQRFGKVSQGILDPGKNEELTDELLGCLVEELLAIDEKDNNSCRI 1176

  Fly  1237 ---------------RVRDAVNRLDMDLEDGLRERRLIG-------------QVKSLNSSDKVHI 1273
                           |..:.:..||.:..|...:|.:.|             :.::|:.:...|.
  Rat  1177 MTNEADTRDLNLVFGRRGNTIEGLDRETTDVKLQRCINGFQIYDEENFLTSYEERTLSDNSLKHE 1241

  Fly  1274 RARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRA----LKNVAEELKILE 1334
            .|    ..|.:|..:|:|.:|.||..: .:.|:|:|:|::|:...:..|    .:.:.||:.:|:
  Rat  1242 EA----IFWTKGEILGRGAYGTVYCGL-TSLGQLIAVKQVALDSTDKLATEKEYRKLQEEVDLLK 1301

  Fly  1335 GIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHG 1399
            .:||.|:|.|.|..:....|.||||....|::.|::...|.|||.:..::|.|:|.||:.||::.
  Rat  1302 ALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPETVFCKYTRQILQGVAYLHENC 1366

  Fly  1400 IVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQ------AHTTVPGELQGYVGTQAYMAPEVFTKT 1458
            :||||||..|:.|:. :..:||.|||.|.::.      .|:.:   |:...||..:|||||.
  Rat  1367 VVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLAWAGLNGTHSDM---LKSMRGTPYWMAPEVI--- 1424

  Fly  1459 NSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG--MGEKPQAPESLSQEGHDFIDH 1521
            |..|:||.:||||:||.|.|||:||.|.|..| ....||.:|  .|..|..|:..|:...||:..
  Rat  1425 NESGYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLMPPLPDRFSEPAADFVRL 1488

  Fly  1522 CLQHDPKRRLTAVELLEHNF 1541
            ||..|...|.:|::||.|.|
  Rat  1489 CLTRDQHERPSALQLLTHAF 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	100/273 (37%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	99/270 (37%)
Map3k19	XP_038947212.1	ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786	3/11 (27%)
		ANK repeat	135..179	CDD:293786	9/45 (20%)
		STKc_YSK4	1244..1509	CDD:270801	100/274 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920