DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and Map3k5

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_032606.4	Gene:	Map3k5 / 26408	MGIID:	1346876	Length:	1380	Species:	Mus musculus

Alignment Length:	848	Identity:	202/848 - (23%)
Similarity:	336/848 - (39%)	Gaps:	213/848 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   841 SPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQ 905
            |..:||:..|....|    ..||..|...||.|.|:|.:    .|....::..:..:|:..|:.:
Mouse   235 SSFMKGLTELMQPNF----ELLLGPICLPLVDRFVQLLK----VAQASSSQYFRESILSDIRKAR 291

  Fly   906 SLLTVE---------RER--SIKVL-----FFAKTFCRDVETTDFHREHYE-------HDVANQQ 947
            :|.|.:         |:|  :|:||     .......||::..|...:..|       .|:|:..
Mouse   292 NLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHH 356

  Fly   948 HDFICSDVK--AAFKLLQQ----------DVL--------QVRNKLTAIIEGVQKRCCL-SNMRD 991
            |      ||  .||.|.::          |::        ||.:.:..::..:.|...| ||..|
Mouse   357 H------VKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTD 415

  Fly   992 LDEQDK---------------QAVLSRTREILHQGYKF--GFEYHKDVIRLFEQKIMDQKDS--- 1036
            .:.:|.               |:.::....:|..|::|  .||..|..::|  ..::.:|.:
Mouse   416 TESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKL--SSLLGKKGNLEK 478

  Fly  1037 --GAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEA 1099
              ....|...||....|...:..:....:..|...|.|..:.:...||
Mouse   479 LQSYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETIL----------------- 526

  Fly  1100 LKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQS 1164
                   ...|.:.:|:| :..||::...........||....|..|.|:   ::|.|.  .:..
Mouse   527 -------IYKHFVKLTTE-QPSAKQELVDFWMDFLVEATKTDVTVVRFPV---LILEPT--KIYQ 578

  Fly  1165 PPY----NKLLHPQFS----LKEDVSG--------TSYSPVDSSDYVDTPC-----QRSANGELR 1208
            |.|    |::.....|    |.:|..|        :|...|..|.:.:..|     ..|.:.::.
Mouse   579 PSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHNSDDFQIY 643

  Fly  1209 LLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSL-------N 1266
            ...                    .|..:|..:.||.:..:...|..:....|.  ||       .
Mouse   644 FCT--------------------ELHCKRFFEMVNTITEEKGRGAEDGDCEGD--SLEYDYEYDE 686

  Fly  1267 SSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELK 1331
            :.|:|               .:|:|.:|.||...:.:....:|:|||..:  ::|..:.:.||:.
Mouse   687 NGDRV---------------VLGKGTYGIVYAGRDLSNQVRIAIKEIPER--DSRYSQPLHEEIA 734

  Fly  1332 ILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVE-----LTGNLPEALTRRFTAQLLSG 1391
            :.:.:||||:|:|.|.......:.||||....|:|.:|:.     |..|  |.....:|.|:|.|
Mouse   735 LHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDN--EQTIGFYTKQILEG 797

  Fly  1392 VSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFT 1456
            :..||.:.|||||||..|:.:...|..||:.|||::.::..   :....:.:.||..|||||:..
Mouse   798 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG---INPCTETFTGTLQYMAPEIID 859

  Fly  1457 KTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGE-KPQAPESLSQEGHDFID 1520
            | ...|:|:||||||:||.::|||:||.|:.:.......||||||.: .|:.|||:|.|...||.
Mouse   860 K-GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFIL 923

  Fly  1521 HCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVR------GS--FRRNVA---------T 1568
            .|.:.||.:|..|.:||...|.|     .||::.:.|.:      ||  :.|:::         |
Mouse   924 KCFEPDPDKRACANDLLIDEFLK-----VSSKKKKTQPKLSALSTGSNEYLRSISLPVPVLVEDT 983

  Fly  1569 SSS 1571
            |||
Mouse   984 SSS 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	94/266 (35%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	94/264 (36%)
Map3k5	NP_032606.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..97
		DUF4071	172..551	CDD:290020	67/356 (19%)
		Interaction with PPIA/CYPA. /evidence=ECO:0000250\|UniProtKB:Q99683	649..1374		115/368 (31%)
		STKc_ASK	678..945	CDD:270794	97/289 (34%)
		S_TKc	692..945	CDD:214567	94/260 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1188..1215
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1672
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940