DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and Map3k2

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_036076.2	Gene:	Map3k2 / 26405	MGIID:	1346873	Length:	619	Species:	Mus musculus

Alignment Length:	475	Identity:	146/475 - (30%)
Similarity:	218/475 - (45%)	Gaps:	67/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1094 DDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPN 1158
            :.|.|.:.:.||:.:..:  ..|.||    ...|.......||....|...:|.|.:
Mouse   187 NSEGEFIPESMDQMLDPL--SLSSPE----NSGSGSCPSLDSPLDGESYPKSRMPRA-------- 237

  Fly  1159 TPPLQSPPYNKLLHPQFS-------LKEDVSGT-------SYSPVDSSDYVDT-PCQRSANGELR 1208
                ||.|.|   |.:|:       .|....||       ||...:.:|...| |..|...|...
Mouse   238 ----QSYPDN---HQEFTDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSF 295

  Fly  1209 LLVPQTPPTPASPGKSSLES--TPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSD-K 1270
            .......||..|...||..|  ||     |.....:.|...|:::           .:|..:| .
Mouse   296 RSPVSFSPTDHSLSTSSGSSVFTP-----EYDDSRIRRRGSDIDN-----------PTLTVTDIS 344

  Fly  1271 VHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQP--GETRALKNVAE-ELKI 1332
            ...|:......|..|..:|||.||:||...:.:||..:|:|::...|  .||....|..| |:::
Mouse   345 PPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQL 409

  Fly  1333 LEGIKHKNLVRYYGI--EVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSEL 1395
            |:.:.|:.:|:|||.  :...:.|.||||....|:::..::..|.|.|.:||::|.|:|.||..|
Mouse   410 LKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL 474

  Fly  1396 HKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNS 1460
            |.:.|||||||.||| |.|.:.::||||||::.::|........::...||..:|:|||.   :.
Mouse   475 HSNMIVHRDIKGANI-LRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI---SG 535

  Fly  1461 DGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG-MGEKPQAPESLSQEGHDFIDHCLQ 1524
            :|:||.||||||.|.||||.:.|.|||:|:: ...:||:. ....|:.|..:|....||:.....
Mouse   536 EGYGRKADIWSVACTVVEMLTEKPPWAEFEA-MAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFV 599

  Fly  1525 HDPKRRLTAVELLEHNFCKY 1544
             :.|.|.:|.|||.|.|..|
Mouse   600 -EAKLRPSAEELLRHMFVHY 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	101/266 (38%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	101/264 (38%)
Map3k2	NP_036076.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44
		PB1_Mekk2_3	44..122	CDD:99726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..247		14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..355		15/81 (19%)
		STKc_MEKK2	353..616	CDD:270818	101/268 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920