DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mekk1 and wis4

DIOPT Version :9

Sequence 1:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_593557.1 Gene:wis4 / 2542873 PomBaseID:SPAC9G1.02 Length:1401 Species:Schizosaccharomyces pombe


Alignment Length:1699 Identity:336/1699 - (19%)
Similarity:594/1699 - (34%) Gaps:613/1699 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SNRRRVRTIDYLALQQSLRLQKTPAATTNAEEQVAREEENGNGHHSTVTAETPPTPPIPPIPPIR 66
            |.:|....:.::.|        ||:.:..:|:.:           ||.|:.:|...|        
pombe    57 STKRSENFVSHIPL--------TPSHSGQSEKLM-----------STRTSHSPYISP-------- 94

  Fly    67 LRREQSVEEDVARVEYRVKQTPSRPVQMTRNRIGALEEDMPPEDELAAHYEAFGTT---PPRTRL 128
                            .:..|...|..:|||.              :.:::.:.||   ||..| 
pombe    95 ----------------TMSYTNHSPANLTRNS--------------SFNHQHYSTTLRSPPSMR- 128

  Fly   129 KIKNRDWERKQKVVNVTAS----ADLPASVGGTPKKTRTARSRVLRRNTMDCALL--NEMFVN-D 186
                      .:.::|.:|    ...|        :|.:...::..|..:|...:  |..|.| |
pombe   129 ----------GRGIDVNSSHYPHISRP--------RTSSDSQKMYTRAPVDYYYIQENPYFNNID 175

  Fly   187 ESKRTDKRLQSL---LRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPIP 248
            :...:||.|.|.   |..||.:.::.           |.|.|:.||...:|....:::       
pombe   176 QDSISDKSLPSTNQSLHHSEEDTESD-----------NDFSESIHPEFDIDVFYKVSN------- 222

  Fly   249 LRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFANL 313
                                 |.|..|                  ....|...:|.::|...:::
pombe   223 ---------------------ILYDES------------------DLQDPEKRERLEWHSMLSSV 248

  Fly   314 IKLGSV---DRQDAKLSQEEHTWQTELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSDLLTHI 375
            :| |.|   :::..:|::.:....|.:.: :||.||||...|....|.:.:.::|:||..:|..:
pombe   249 LK-GDVMQTEKRRLRLTEPDGHSGTYISE-VWLGLQAWLHGRLNADQAEVIRKSREGVEPVLREV 311

  Fly   376 INYKFQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSLYCKDCMDHQELALREVEGML 440
            |:::.|.....:|                                           .|.:|..:|
pombe   312 IDFQIQDEETTKP-------------------------------------------PLEQVTEIL 333

  Fly   441 TRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNITKQNKLKLSILGKILARLQDEKFS 505
            .::|..:..|.||:.|....|:..|:.|..::.::..|.|:.:..:::..:|.|.:.   :::|.
pombe   334 EKVEQCKQFYISSREMEENVPLSASKEFNYKLNALISWSNVMESIQVETLVLQKWVG---NDEFD 395

  Fly   506 WPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVP 570
            ..:.|..:        :..||||                                          
pombe   396 LTMRTPQF--------NYDGVEN------------------------------------------ 410

  Fly   571 GETSSSNESTSTEVSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENV 635
              |||                                                       |:|.:
pombe   411 --TSS-------------------------------------------------------FVERI 418

  Fly   636 LKSRGL-----AKSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDVPRLDPEISREQ 695
            .:..||     .::|..|:::    :::|...:.:          :|::.||             
pombe   419 FRQSGLQRTFEQRTLTTLNRI----IHQAKQTISE----------NAQAFEE------------- 456

  Fly   696 VVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLE-TRPVR-PNPLSLEQLMKE 758
                            :.||:|....:.|...|::.:.|.||:||. .:.:: ||.|.::.::.:
pombe   457 ----------------MKLPTYEDKLLPLVRFPIKLLEEALRLRLAYAKKIKGPNFLIVDSMLDD 505

  Fly   759 LREGLTLALTHRERYQRHITT----ALVENEAELGSYISILNHYDATVRKTFELYLEYIDQLVLV 819
            .:..|::|:..:..|.:..:.    :|..|..|         .||..:..:.:.|.    :|:.:
pombe   506 FKIALSVAVRIKREYIKIASPSPGWSLPTNVDE---------DYDNVLLDSLKFYF----KLLTL 557

  Fly   820 AVPEGNQK------SVLEKEWMFTKLISPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELD 878
            .:..||:.      ..||.||.|.......|.|.....:.:|..:.:.||.:     |.|.||  
pombe   558 KLSSGNKNLYFKEIDFLENEWAFLNEHIYWINGGDIHMAGQFSYLSNSLLLN-----VHRYVE-- 615

  Fly   879 QQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERSIKVLFFAKTF-CRDVETTDF-----H-- 935
            ..::|..:........| ..|:.:.||.       |..|:|.|::|. .|....:||     |  
pombe   616 SHLNGPTERTAASLTNW-YSTLLKNTQI-------RFRKILRFSETLNSRFENASDFVISEGHLP 672

  Fly   936 --------REHYEHDVANQQHD--FICSD---------VKAAFKLLQQDVLQVRNKLTAIIEGVQ 981
                    ..|:....||.:.|  |:.:|         :||.  |..:|:        :.:|.:|
pombe   673 DLVNRLSTTGHFLAYTANLERDGVFVIADHTLSENPEALKAL--LFSKDI--------SNLETIQ 727

  Fly   982 KRCCL-------------SNMRDLDEQD---------KQAVLSRTREILHQGYKFGFE------- 1017
            :.|..             ..:..:|..|         .:.:.|..||.| |..|..|:       
pombe   728 QNCSYVLILCPVHPIVWKGRIEKVDVPDFSVDLKTNRVRIIASNKREHL-QAAKSVFQSISGDLV 791

  Fly  1018 ------------YHKDVIRL------FEQKIMD------QKDSGAHTVDLALGIIAYA------- 1051
                        .:|:.|||      ....::|      :..||.:..||...:.::|       
pombe   792 TLAVECRSSITRVYKEFIRLSKLCMRISSTVVDCVSAVREACSGVNCHDLIYHVFSFAAEFGQRI 856

  Fly  1052 ------------KM----------WMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDD 1094
                        |:          |:.|:.:.|:.......||....||||:|.........:||
pombe   857 LRFLSFDSYWQTKLKRKITSLAVEWISFICDECDLMDRKTFRWGVGALEFLMLMIRGNNILLIDD 921

  Fly  1095 DEFEALKQQMDRCISHVI---GITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLN 1156
            ..|..:::::.:.::.::   .:.....|||.|.....|..:|||..                  
pombe   922 AMFLKIREKVGKSMAFLLTHFDVLGAKSKVAAKLQRESTEVSSSPRL------------------ 968

  Fly  1157 PNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASP 1221
                                       ||:..|:.                              
pombe   969 ---------------------------TSFGDVEE------------------------------ 976

  Fly  1222 GKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQV---KSLNSSDKVHIRA--RSVHFR 1281
                 |:..:.|.|:.....::.|:::..:.|.||..||.|   ....:.|.:.:.:  .::..|
pombe   977 -----EALSIQLLQKETMLRIDELEIERNNTLLERLAIGHVLDDSVFRNRDFIKLASSFSNITIR 1036

  Fly  1282 WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGET--RALKNVAEELKILEGIKHKNLVRY 1344
            |.:|..:..|.||.|||.||..||:|:|:|||.:|...|  ..:..:..|:.:||.:.|.|:|.|
pombe  1037 WQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTY 1101

  Fly  1345 YGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTAN 1409
            ||:|||||::.||||.|..|:|..|:.......|.:.:.:..|||.|::.:|...|:|||||.||
pombe  1102 YGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPAN 1166

  Fly  1410 IFLVDGSNSLKLGDFGSAVKIQAHT-------TVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAA 1467
            | |:|....:|..|||||:.:...|       .:..|||...||..|||||:...|.....| |.
pombe  1167 I-LLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFG-AM 1229

  Fly  1468 DIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAP--ESLSQEGHDFIDHCLQHDPKRR 1530
            ||||:|||::||.:|..||::.|:.:.||:.|.....|..|  |.:|....|||:.|.:.||::|
pombe  1230 DIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQR 1294

  Fly  1531 LTAVELLEH 1539
            ..||:||.|
pombe  1295 PRAVDLLTH 1303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mekk1NP_732373.1 STKc_MEKK4 1281..1542 CDD:270796 111/270 (41%)
S_TKc 1282..1541 CDD:214567 110/269 (41%)
wis4NP_593557.1 STKc_MEKK4 1036..1306 CDD:270796 111/270 (41%)
S_TKc 1037..1306 CDD:214567 110/269 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 199 1.000 Domainoid score I665
eggNOG 1 0.900 - - E1_KOG4645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 326 1.000 Inparanoid score I536
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002637
OrthoInspector 1 1.000 - - otm46980
orthoMCL 1 0.900 - - OOG6_104404
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1672
SonicParanoid 1 1.000 - - X2354
TreeFam 00.000 Not matched by this tool.
98.880

Return to query results.
Submit another query.