Protein Alignment Mekk1 and byr2

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_595714.2
• Gene: byr2 / 2540612
• PomBaseID: SPBC1D7.05
• Length: 659
• Species: Schizosaccharomyces pombe
• Alignment Length: 831
• Identity: 198/831 - (23%)
• Similarity: 321/831 - (38%)
• Gaps: 236/831 - (28%)

  Fly   752 LEQLMKELREGLTLALTHRERYQRHITTAL-----VENEAELGSYISILNHYDATVRKTFELYLE 811
            :||..:...||         |:..|:|..|     :||.|:...::           |..:...|
pombe    22 IEQFSQNNIEG---------RHLNHLTLPLLKDLGIENTAKGKQFL-----------KQRDYLRE 66

  Fly   812 YIDQLVLVAVPEGNQKSVLEKEWMFTKLISPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVE 876
            :....:|..:....|...::....:.|.::..:|......:.||...:|:..|      :|...|
pombe    67 FPRPCILRFIACNGQTRAVQSRGDYQKTLAIALKKFSLEDASKFIVCVSQSSR------IKLITE 125

  Fly   877 LDQQIDGTADTDDNEEVKWQLLTICRETQS-----LLTVERERSIKVLFFAKTFCRDVETTDFHR 936
                          ||.|    .||..:.|     |:.|.:|:.          |...|..   |
pombe   126 --------------EEFK----QICFNSSSPERDRLIIVPKEKP----------CPSFEDL---R 159

  Fly   937 EHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAII-EGVQKRCCLSN----MRDLDEQD 996
            ..:|.::|.          .||  |..|..|.  .||:::: ...|||...||    ........
pombe   160 RSWEIELAQ----------PAA--LSSQSSLS--PKLSSVLPTSTQKRSVRSNNAKPFESYQRPP 210

  Fly   997 KQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMER 1061
            .:.:.||..:.        |..|       :.|::::..|.:...:|::               |
pombe   211 SELINSRISDF--------FPDH-------QPKLLEKTISNSLRRNLSI---------------R 245

  Fly  1062 CERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKK-K 1125
            ..:|..:    .:.|.|.|     |:.::.....|.             |..::|....||:. .
pombe   246 TSQGHNL----GNFGQEIL-----PRSSRRARPSEL-------------VCPLSSLRISVAEDVN 288

  Fly  1126 ASPRTRKTSSP-----ATSRSRTPTRTPMSAGMVLNPNTPPL-------QSPPYNKLLHPQFSLK 1178
            ..||..:...|     :|.|...|.....|..||   ...||       :|..||     .||
pombe   289 RLPRIDRGFDPPLTVSSTQRISRPPSLQKSITMV---GVEPLYQSNGNEKSSKYN-----VFS-- 343

  Fly  1179 EDVSGT----SYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVR 1239
            |...|.    |:||..|..:::                  .|:|.||..::.|.|
pombe   344 ESAHGNHQVLSFSPGSSPSFIE------------------QPSPISPTSTTSEDT---------- 380

  Fly  1240 DAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNT 1304
               |.|:.|.:|                        :|:  :|.||..||.|.||:||..:|.::
pombe   381 ---NTLEEDTDD------------------------QSI--KWIRGALIGSGSFGQVYLGMNASS 416

  Fly  1305 GELMAMKEIAI------QPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSE 1363
            |||||:|::.:      :....:.|..:|.|:.:|:.:.|:::|:|.|..::.:.|.||:|....
pombe   417 GELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPG 481

  Fly  1364 GTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAV 1428
            |::..|:.:.|:..|.|.:.|..|.|.|:..||..||||||||.||| |||....:|:.|||.:.
pombe   482 GSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANI-LVDNKGKIKISDFGISK 545

  Fly  1429 KIQAHTT---VPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFD 1490
            |::.::|   ..|....:.|:..:|||||..:|.   |....||||:||:|:||.:.|.|:...|
pombe   546 KLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTM---HTEKTDIWSLGCLVIEMLTSKHPYPNCD 607

  Fly  1491 SNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF 1541
             ..|.:|::|....|:.|.::|....||::.....|...|.||.|||.|.|
pombe   608 -QMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPF 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	33/187 (18%)
		STKc_MEKK4	1281..1542	CDD:270796	98/270 (36%)
byr2	NP_595714.2	SAM_2	1..65	CDD:429573	12/62 (19%)
		Protein Kinases, catalytic domain	393..658	CDD:473864	98/270 (36%)