DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and Map3k19

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_035867.2	Gene:	Map3k19 / 22625	MGIID:	1203481	Length:	1515	Species:	Mus musculus

Alignment Length:	1595	Identity:	338/1595 - (21%)
Similarity:	541/1595 - (33%)	Gaps:	463/1595 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 WERKQKVVNVTASA------------DLPASVGGTPKKTRTARSRVLRRNTMDCALLNEMFVNDE 187
            | |||:::::...:            |:....|.||.                     ||.|:..
Mouse   195 W-RKQQLLDILMDSMPRPERHAESLLDICHEAGSTPM---------------------EMTVSQT 237

  Fly   188 SKRTDKRLQSLLRDSEREMKNSLATTAV----AAPRGNSFHETAHPLESLDQIMPLNSEAMAPIP 248
            ...|   |||:....:.::::..:...:    |||||.::......:|.:        ....|.|
Mouse   238 ENLT---LQSISSSEDFDLEDDFSPFILAREGAAPRGENWPRRTEGVEII--------VTFPPDP 291

  Fly   249 LRIASKVVESCNRYRCVSS--------RPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKD 305
            |:.||:  |.......|:|        .|:    |.|..|....|...||.:.    |.|.|...
Mouse   292 LQEASQ--EDLKESNQVTSEHQEREQVHPV----SPPDDAEMVGLTGRMLTTQ----PSLLKTDG 346

  Fly   306 FHETFANLIKLGSVDRQDAKLSQEEHTWQTELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSD 370
            ..|....:         |..||.......:.|           .|....|.....|.|.::...:
Mouse   347 SSEELCGV---------DVALSPPRPCLDSSL-----------AASAAGEVAPCVLKEQQRQSDE 391

  Fly   371 LLTHIINYKFQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSLYCKDCMDHQELA--- 432
            ..|..|:|                      |:.....|||...|     |..:.|:.:.|.:
Mouse   392 FPTSDISY----------------------SSRRTGLPLPPLSC-----LPMRSCIFNMEKSPKS 429

  Fly   433 --LREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVG-----------------RIKSMCLW 478
              .||.:.....|...:.|.|.|:      |:.:|..|..                 |..:..||
Mouse   430 PRHRERKVPSLSLSVPKLLEPLSR------PLSQSAEFSSSKNHQEVTQEGPVEHTLRGSNCTLW 488

  Fly   479 YNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPS 543
                .:|.......||     |....|||               :..:|..|....|.....|..
Mouse   489 ----SRNMCSFRKSGK-----QGVAESWP---------------SQEMEGWDKTKTSGFKEGPSL 529

  Fly   544 MAGSASRKGVTPCHKVQFMLNDATHVP-----GE-----TSSSNESTSTEVSQWSSECSHSHMRK 598
            .:..:.::..||..:.:   :...||.     ||     :|...||.:..|.:..|...|..:.|
Mouse   530 FSCESVKEDTTPTERER---DSGYHVSEMQRGGEDSQYLSSRKKESWTARVVERDSGVEHPILCK 591

  Fly   599 GSMHDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIAL 663
                   :..|          :..:.|....|.|.|                 .||...|:: ::
Mouse   592 -------LLEV----------SNSEMTPAEEKEIGN-----------------ENVPDAKSN-SV 621

  Fly   664 EKPGAEDFDYESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSG-I 727
            .|.||    .|..|.|.|..||:..|.::.:...| ...|:...| |:..:|....|...::| :
Mouse   622 HKSGA----MEPHAASEEVSVPKNGPSVNSDGPAE-ELEGHRDIE-QNRKIPMEEETNPEMNGVV 680

  Fly   728 PLQFMHEFLRMRLETRPVRPNPLSLEQLMKELREGLTL-ALTHRERYQRHITTALVENEAELGSY 791
            ||..: .|........|.|..| .|::..:..:...:. .|.|||..:....|    :..:|.|.
Mouse   681 PLTHI-AFPGEGTSKGPARAEP-HLQRRKRPAQNSNSFNLLAHREHDKLQTNT----HRTKLDSR 739

  Fly   792 ISILNHYDATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLI------SPMIKGMHTL 850
            ....|.....:..:.:..::          |..::.|:..:.:...:||      |...:....|
Mouse   740 TKARNRAPPNLMVSIQASIK----------PNMHKNSIKTQVFPALELIDHRPHPSSKFQRRAPL 794

  Fly   851 ASQKFCGIISKLLRSISERLVKRTVELDQQIDGTADTDDNE----EVKWQLLTICRETQSLLTVE 911
            ..:|......|..:....|:.|........|..:|:|.|..    ::|:.  .:.:|..|   ..
Mouse   795 TEKKSTHQTQKPKKQAFPRIGKHAGIKKPGIPLSAETTDPRLHFLDLKYS--DMFKEINS---AS 854

  Fly   912 RERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFIC-SDVKAAFKLLQQDVLQVRNKLTA 975
            ....|..:|....:|              |....::||..| .:::.|
Mouse   855 NGPGIYEMFGTPVYC--------------HIREAERHDHRCYREIRTA----------------- 888

  Fly   976 IIEGVQKRC----CLSNMRDLDEQDKQAVLSRTREI-----LHQGYKFGFEYHKDVIRLFEQKIM 1031
                ...||    |.|:..|.....:..:|.:.:.|     || |.:   :.|    |.|..|..
Mouse   889 ----PSGRCVVNKCQSSESDRCSNSRARLLQKRQHIKPPKPLH-GLR---QKH----RGFISKDK 941

  Fly  1032 DQKDSGAHTVDLALGIIAYAK-------------MWMHFV------------------------- 1058
            ..||.|.||.|.........|             ..||.:
Mouse   942 GCKDMGGHTEDSVSEPDGQMKSPGNDFLSSKDDAQLMHLIPIPELSPEQKAPAPVSDLSIVEEIF 1006

  Fly  1059 MERCERGRGMRPRWASQGLEFLILACDPQITQHLDD-DEFEALKQQMDRCISHVIGITSE----- 1117
            .|.|....|              :..|..:||.|.| .|.|.|..|...       :.||
Mouse  1007 TEECADEEG--------------ILNDDSLTQSLGDLKEPEGLHPQAPL-------VPSENSWAV 1050

  Fly  1118 -PEKVAKKKASPRTR---------------------------KTSSPATSRS------RTPTRTP 1148
             .||.:.|:.||...                           ||....:|.|      |.|:.|.
Mouse  1051 LSEKRSGKRVSPEKHNVEPLDKINAEQMFPGYLEFDSLSEKSKTLVSFSSCSFQENLERAPSPTE 1115

  Fly  1149 MSAGMVLNPNTPPLQSPPY-------NKLLHP--QFSLKEDVSGTSYSPVDSSDYVD-TPCQRSA 1203
            ......|..::....|..|       .::|.|  ...|.:::.|.....:.:.|..| ..||...
Mouse  1116 QHWARSLEQDSLENNSTTYQTFGKISQEILDPGKNEELTDELLGCLVEELLALDEKDNNSCQIMT 1180

  Fly  1204 N----GELRLLVPQTPPTPASPGKSSLESTPLALRQ----ERVRDAVNRLDMDLEDGLRERRLIG 1260
            |    ..|.|:..:...|....|:   |:|.:.|::    .|:.|..|.|..:      |::.:.
Mouse  1181 NEADAKNLNLVFSRRGNTIEELGR---ETTDVKLQRCINGFRIYDEENFLTSN------EKKTLS 1236

  Fly  1261 QVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRA--- 1322
            . ||||..:.:.         |.:|..:|:|.:|.||..: .:.|:|:|:|::|:...:..|
Mouse  1237 D-KSLNHEEAIF---------WTKGEILGRGAYGTVYCGL-TSLGQLIAVKQVALDTSDKLATEK 1290

  Fly  1323 -LKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTA 1386
             .:.:.||:.:|:.:||.|:|.|.|..:....|.||||....|::.|::...|.|||.:..::|.
Mouse  1291 EYRKLQEEVDLLKALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTR 1355

  Fly  1387 QLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQ------AHTTVPGELQGYVG 1445
            |:|.||:.||.:.:||||||..|:.|:. :..:||.|||.|.::.      .|:.:   |:...|
Mouse  1356 QILQGVAYLHDNCVVHRDIKGNNVMLMP-TGIIKLIDFGCAKRLAWAGLNGTHSDM---LKSMRG 1416

  Fly  1446 TQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG--MGEKPQAP 1508
            |..:|||||.   |..|:||.:||||:||.|.|||:||.|.|..| ....||.:|  .|..|..|
Mouse  1417 TPYWMAPEVI---NESGYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLMPPLP 1477

  Fly  1509 ESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK 1543
            ...|:...||:..||..|...|.:|::||:|:|.|
Mouse  1478 ARFSEPAADFVRLCLTRDQHERPSALQLLKHSFLK 1512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	99/272 (36%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	99/270 (37%)
Map3k19	NP_035867.2	ANK repeat	44..74	CDD:293786
		ANK repeat	76..133	CDD:293786
		ANK repeat	135..179	CDD:293786
		STKc_YSK4	1246..1511	CDD:270801	99/282 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910