Protein Alignment Mekk1 and pak-1

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_001024377.1
• Gene: pak-1 / 180873
• WormBaseID: WBGene00003911
• Length: 572
• Species: Caenorhabditis elegans
• Alignment Length: 587
• Identity: 137/587 - (23%)
• Similarity: 249/587 - (42%)
• Gaps: 104/587 - (17%)

  Fly  1019 HKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILA 1083
            :||.....|:.::.:..:..||:.     :.|......|.        ||...||.       |.
 Worm    55 NKDKKEASEKPVISRPSNFEHTIH-----VGYDPKTGEFT--------GMPEAWAR-------LL 99

  Fly  1084 CDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTP 1148
            .|.||::.        .:||..:.:...:...::.|...:|...........       .|:|||
 Worm   100 TDSQISKQ--------EQQQNPQAVLDALKYYTQGESSGQKWLQYDMMFIDD-------APSRTP 149

  Fly  1149 MSAGMVLNPNTPPLQSPPY--NKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLV 1211
             |.|  |.|......|.||  ||:..|: .:....:.||.:..:|...| .|...|.|.....:.
 Worm   150 -SYG--LKPQPYSTSSLPYHGNKIQDPR-KMNPMTTSTSSAGYNSKQGV-PPTTFSVNENRSSMP 209

  Fly  1212 PQTPPTPASPGKSSLESTPLAL----------------RQERVRD------AVNRLDMDLEDGLR 1254
            |...|.|...|::..:..|.|:                .:|::.|      .|.......:..:.
 Worm   210 PSYAPPPVPHGETPADIVPPAIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMT 274

  Fly  1255 ERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGE 1319
            :..::.:::::.|......:.|.|.       |||.|..|.||||:..:|...:|:|::.::...
 Worm   275 DAEVLTKLRTIVSIGNPDRKYRKVD-------KIGSGASGSVYTAIEISTEAEVAIKQMNLKDQP 332

  Fly  1320 TRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLV---ELTGNLPEALT 1381
            .:.|  :..|:.::...||.|:|.|....:..:||.:.||..:.|:|..:|   ::...:..|:.
 Worm   333 KKEL--IINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVC 395

  Fly  1382 RRFTAQLLSGVSELHKHGIVHRDIKTANIFL-VDGSNSLKLGDFGSAVKI----QAHTTVPGELQ 1441
            |    ::|..:..||...::|||||:.||.| :||  |:||.|||...::    :..||:
 Worm   396 R----EVLQALEFLHSRHVIHRDIKSDNILLGMDG--SVKLTDFGFCAQLSPEQRKRTTM----- 449

  Fly  1442 GYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQ 1506
              |||..:|||||.|:..   :|...|:||:|.:.:||..|:.|:.. ::..:.::.:....||.
 Worm   450 --VGTPYWMAPEVVTRKQ---YGPKVDVWSLGIMAIEMVEGEPPYLN-ENPLRAIYLIATNGKPD 508

  Fly  1507 AP--ESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRNVATS 1569
            .|  :|::....||:|..|:...:.|.:|.:||.|.|.:..:...|...|.:    :.::::|.:
 Worm   509 FPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFLRCAKPLASLYYLIV----AAKKSIAEA 569

  Fly  1570 SS 1571
            |:
 Worm   570 SN 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077
		STKc_MEKK4	1281..1542	CDD:270796	80/270 (30%)
pak-1	NP_001024377.1	PBD	67..123	CDD:395634	14/83 (17%)
		Protein Kinases, catalytic domain	287..547	CDD:473864	84/285 (29%)