DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mekk1 and gck-1

DIOPT Version :10

Sequence 1:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_505310.2 Gene:gck-1 / 179274 WormBaseID:WBGene00001526 Length:803 Species:Caenorhabditis elegans


Alignment Length:470 Identity:125/470 - (26%)
Similarity:217/470 - (46%) Gaps:103/470 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1132 KTSSPATSRSRTPTRTPMSAGMVLNPNTPPL-QSPPYNKLLH----PQFSLKEDVSGTSYSPVDS 1191
            :|::..::..|...|.|:||        ||. :|.|:.::|.    |.|..|::    ||   ||
 Worm    12 RTTNVQSAIQRFEKRAPVSA--------PPYRESEPFREVLKDEPAPPFLQKQN----SY---DS 61

  Fly  1192 SDYVDT----PCQRSANGELRLLVPQ-TPP------------------------------TPASP 1221
            ..:|:|    |.::::      ..|| |||                              .|::.
 Worm    62 PLFVNTNIVYPVEQNS------YFPQITPPREHVTYGIMNDSKMDDSIDSATLNRFETGFKPSNF 120

  Fly  1222 GK------SSLE---STPLALRQERVRDAVNRLDMDLEDGL-RERRLIGQVKSLNSSDKVHIRAR 1276
            ||      :|.|   .||..:....:...:|.:..::.... .|||.:  ||.:..:.|:.   .
 Worm   121 GKTIQGIYNSTEHPQQTPEVVLPSSLSVDLNVMSPEVSPPKPAERRKV--VKPIEDNSKLD---P 180

  Fly  1277 SVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNL 1341
            .|.|.  :..:||:|.||:||..::|.||.::|:|.|.::..|.. ::::.:|:::|.....:.:
 Worm   181 EVIFT--KQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDE-IEDIQQEIQVLSQCDSQYV 242

  Fly  1342 VRYYGIEVHREELLIFMELCSEGTLESLVELT--GNLPEALTRRFTAQLLSGVSELHKHGIVHRD 1404
            .:|:|..:...:|.|.||....|   |.::||  |.|.|:.......::|.|:..||....:|||
 Worm   243 TKYFGSFLKGSKLWIIMEYLGGG---SALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRD 304

  Fly  1405 IKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADI 1469
            ||.||: ||.....:|:.|||  |..|...||...:. :||:..:||||:..:::.|   ..|||
 Worm   305 IKAANV-LVSEHGDVKVADFG--VAGQLTETVKKRIT-FVGSPFWMAPELIKQSSYD---YKADI 362

  Fly  1470 WSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGH------DFIDHCLQHDPK 1528
            ||:|...:|:|:|:.|.:.... .:::|.:     |:.|..:.|...      :|::.||..||:
 Worm   363 WSLGITAIELANGEPPHSDLHP-MRVLFLI-----PKNPPPVLQGSQWSKPFKEFVEMCLNKDPE 421

  Fly  1529 RRLTAVELLEHNFCK 1543
            .|.:|..||:|.|.|
 Worm   422 NRPSASTLLKHQFIK 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mekk1NP_732373.1 MEKK4_N 105..>930 CDD:466077
STKc_MEKK4 1281..1542 CDD:270796 81/268 (30%)
gck-1NP_505310.2 STKc_MST3_like 183..455 CDD:270786 84/273 (31%)
Blue background indicates that the domain is not in the aligned region.

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