DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and gck-2

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_504721.1	Gene:	gck-2 / 179072	WormBaseID:	WBGene00022603	Length:	829	Species:	Caenorhabditis elegans

Alignment Length:	288	Identity:	89/288 - (30%)
Similarity:	145/288 - (50%)	Gaps:	29/288 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1262 VKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNV 1326
            :|..|.:|...:..|           :|.|.:|:||.|.:..:..|.|:|.:.::.|:..|:  :
Worm     6 IKRSNPADDYELLQR-----------VGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAV--I 57

  Fly  1327 AEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSG 1391
            .:|:.::....|.|::.|:|..:.|:.|.|.||.|..|:|:.:..|||.|.|........:.|.|
Worm    58 QQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRG 122

  Fly  1392 VSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFT 1456
            ::.||..|.:|||||.||| |:..|..:||.|||.|.:|   |...|:.:.::||..:|||||..
Worm   123 LNYLHNMGKIHRDIKGANI-LLSSSGDVKLADFGVAAQI---TATIGKRKSFIGTPYWMAPEVAC 183

  Fly  1457 KTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSN-FQIMFKVGMGEKPQAPESLSQEG----- 1515
            .....|:|...|:|:.|...:|:...:.|  .||.: .|:::.  |.:....|..|..:.
Worm   184 VEKRGGYGMQCDVWATGITAIELGECQPP--LFDLHPMQVLYL--MTKSGYKPPHLKDKHRWTPL 244

  Fly  1516 -HDFIDHCLQHDPKRRLTAVELL-EHNF 1541
             |||:..||..:||:|.:..:|| .|.|
Worm   245 FHDFVRQCLTKNPKKRPSPEKLLTSHPF 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	85/269 (32%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	84/266 (32%)
gck-2	NP_504721.1	STKc_MAP4K3_like	14..273	CDD:270788	86/280 (31%)
		S_TKc	15..273	CDD:214567	86/279 (31%)
		CNH	483..804	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000