Protein Alignment Mekk1 and mtk-1

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_001367356.1
• Gene: mtk-1 / 172246
• WormBaseID: WBGene00003472
• Length: 1420
• Species: Caenorhabditis elegans
• Alignment Length: 1662
• Identity: 334/1662 - (20%)
• Similarity: 592/1662 - (35%)
• Gaps: 522/1662 - (31%)

  Fly   126 TRLKIKNRDWERKQKVVNVTASADLPASVGGTPKKTRTARSRVLRRNTMDCALLNEMFVNDE--- 187
            ||:....|::..::.:...|.|..:..      ||::|.|.|         .:.::|: :||
 Worm    37 TRMNTSKREYMGRRSLGVATVSTKIKR------KKSKTERDR---------DMYDDMY-DDEGYA 85

  Fly   188 -----SKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPI 247
                 |.....|...:|..|.|..:|.|.:...::...|. ...:||..   :.:.|.|.|::..
 Worm    86 ASPTSSSSCTYRCIPILERSNRNSQNYLPSAESSSSDSND-RVISHPNH---RPILLYSTALSMA 146

  Fly   248 PLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFAN 312
            |.:..|  |||.       |..:.....|.......::...:.::||..:    |:....:...|
 Worm   147 PQQNLS--VESL-------SDALDELEGADRSKLHMEITQFLKKADGEKS----KQIQMSQRLMN 198

  Fly   313 LIKLGSVDRQDAKLSQEEHTWQTELKDLIWLELQAWQADRTVEQ-----------QDKYLFEARQ 366
            ..:.|...|  ..:.:.|||..| .::::||.|:::.:..:..:           :|:.:.:||:
 Worm   199 CPQFGQTMR--LIVEESEHTRYT-FENILWLILKSYFSTTSTGRDVMIGKSEWIAEDEKIVKARK 260

  Fly   367 GVSDLLTHIINYKFQPRYRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSL-YCKDCMDHQE 430
            ....::..|..:||:                 ...|....||..|...:...|. ||::..|
 Worm   261 QYMMVMDMIKEFKFE-----------------VGKNDKDDSPFESLNRRMEFSPDYCENLRD--- 305

  Fly   431 LALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQS----FVGRIKSMCLWYNITKQNKLKLSI 491
             |.:.|..:|.:.|....|:|:..|:..:..:.:.::    ..||:.||.:|.|.......|...
 Worm   306 -ARKRVSDVLDKYETLVDLFPNQNALWKVVELDRGEAEKKLLEGRMTSMRVWLNTLDDLTDKFKA 369

  Fly   492 LGKI--LARLQDEKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKGVT 554
            ||.:  :..:.|.:..|                          ...:|.:.
 Worm   370 LGVLFEIETMPDAEECW--------------------------FRPLDENN-------------- 394

  Fly   555 PCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNG 619
                                                              .||::|.:
 Worm   395 --------------------------------------------------KIFALEDV------- 402

  Fly   620 TGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDV 684
                 ..::.::::|.|..:|:.|.|:.:.|:..:.|.|..|.::||..   .|.:...|.....
 Worm   403 -----RAVFLEYVKNSLNLKGMKKVLSRVEKIIELTLVKTAILMQKPPT---SYAAATASNGPSF 459

  Fly   685 PRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETRPVRPNP 749
            |  ..:..:::..::..:.:.:..:.|:|||.....|.||..:|:|.:..:|.:|..|.|  |:.
 Worm   460 P--FSQTMKDRYGDMIEWRFCNSTSISLNLPPLNNLFFFLVAVPMQLVVHWLEIRAATEP--PDS 520

  Fly   750 LSLEQL-----MKELREGLTLALTHRERYQRHITTALVE--NEAELGSYISILNHYDATVRKTFE 807
            ..|::|     :.:.|:.:..|:    |.:::..|.|..  ::..:..::..|. |:..|...|:
 Worm   521 CLLDELTFDAMITDSRDCVEEAV----RIKKNYLTILQSMCSKCAMPGFLYPLK-YNTYVLDVFK 580

  Fly   808 LYLEYI-----------DQLVLVAVPEGNQKSVLEKEWMFTKLISPMIKGMHTLASQKFCGIISK 861
            .|:.|:           |..:|.        |.||.||......:..:|....|....:|.|:..
 Worm   581 KYIHYVKCWSNCDSVRKDPPLLF--------SRLEMEWSSAVQCAKSVKSALELLCTTYCDIVES 637

  Fly   862 LLRSISERLVKRTVELDQQID--------GTADTDDNEEVKWQLLTI----------------CR 902
            |:|.:.|      |..|.||:        .|...:::||....::||                ..
 Worm   638 LIREVVE------VYADDQIEDIKNRYVYNTDSENEDEEDDEDMITIGSPKKPLVELKAKHRFML 696

  Fly   903 ETQSLLTVERERSIKVLFFAK-----------------------------TFC-----------R 927
            |..||....:||.:::....:                             .||           .
 Worm   697 ELNSLTREVKERELRIFSLLRITLNDSHDAVGYELRSGVDRAQMFHEMVPDFCLIQLTMASDEQG 761

  Fly   928 DVETTDFH-----------------------------------------------REHYEHDVAN 945
            ||...|.|                                               |:|::..|..
 Worm   762 DVNDDDDHVNLKIVLFVYRTSVDKAYVETCMLAISEGRKIDDGCIVIVPDKDHKLRKHWKGRVVK 826

  Fly   946 QQHDFICSDVKAAFKLLQQDVL--QVRNKLTAIIEGVQK---RC----CLSN------------- 988
            ...|   .:.:..::.|:.|::  .....:.|.:|...|   :|    |.||
 Worm   827 IVID---EETRICYRWLRDDIILCLANGSIRADMEHKYKNFLKCISPACSSNFLITSRIQQLTEE 888

  Fly   989 --MRDLDEQDKQ-AVLSRTREI---------------------LHQGYKFGFEYHKDVIRLFEQK 1029
              :..|||:.|: .:|....||                     |.:.:...|:.|:||.::....
 Worm   889 SLLPHLDEERKRIGILLEKTEIRLEPKEEQSKEKSALSSLGFKLEKHFLVAFQIHRDVAKVVSDS 953

  Fly  1030 IMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQIT--QHL 1092
            .||  ..|...|:.||   |..:.||.:|..:........|.|||.|..||....:|:.:  :.:
 Worm   954 FMD--GLGNEMVEKAL---ALTRQWMQYVEVKSTIPSPTLPMWASPGFTFLQYITEPRWSNPEIM 1013

  Fly  1093 DDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNP 1157
            .:|:|:.....:....:.||                           :|.:...||.:.|
 Worm  1014 TNDQFQEFNDLVKLFEAKVI---------------------------KSSSNIGTPGNTG----- 1046

  Fly  1158 NTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPG 1222
                                                   ||.||:           |..|.:...
 Worm  1047 ---------------------------------------TPMQRN-----------TRSTSSKTS 1061

  Fly  1223 KSSLESTPLA------LRQERVRDAVNRLDMD-------LEDGLRERRLIGQVKSLNSSDKVHIR 1274
            .||:|:....      |:.:.:.|..||:|.|       :.|..|...::...|.:.:
 Worm  1062 SSSMENHKRTRKENQMLKLQELEDKRNRIDYDNLQIGKVITDDNRRNFVLATDKKITT------- 1119

  Fly  1275 ARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHK 1339
              ...|:|.....|..|.||.|:.|::.::..::|.|.:.||....:|:::   |:.|...:.|:
 Worm  1120 --KAPFQWALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIES---EINIFRQLIHE 1179

  Fly  1340 NLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRD 1404
            |||:|||::|...:::||||.||:||||.:..  |.:...:.|::|..||..|..||.|.|:|||
 Worm  1180 NLVKYYGVQVEDSDVIIFMEYCSQGTLERICH--GKMDLKMVRQYTNSLLRAVQYLHSHKIIHRD 1242

  Fly  1405 IKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSD-------G 1462
            ||.||||| |....|||||||.:.::...:||.||.|...||..:||||:::....|       |
 Worm  1243 IKPANIFL-DKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSG 1306

  Fly  1463 HGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGM-GEKPQAPESLSQEGHD---FIDHCL 1523
            :||:.|||::|..||.|.:||.|: :..:..||.|.:.. .:||..|: ::.:..|   |.|:|.
 Worm  1307 YGRSVDIWALGATVVNMMTGKVPF-EGQTRHQIAFALCFRKQKPTYPD-IADKRPDVKRFFDNCF 1369

  Fly  1524 QHDPKRRLTAVELLEHNFCKYG---RDECSSEQLQMQ 1557
            :..|..|.||.|||:..|....   :||......|.|
 Worm  1370 EFLPNDRPTAAELLQTTFANVNITFQDENHIPDYQSQ 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	154/911 (17%)
		STKc_MEKK4	1281..1542	CDD:270796	102/271 (38%)
mtk-1	NP_001367356.1	Protein Kinases, catalytic domain	1125..1388	CDD:473864	102/270 (38%)