Protein Alignment Mekk1 and Map3k1

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_446339.2
• Gene: Map3k1 / 116667
• RGDID: 620966
• Length: 1493
• Species: Rattus norvegicus
• Alignment Length: 1667
• Identity: 328/1667 - (19%)
• Similarity: 560/1667 - (33%)
• Gaps: 549/1667 - (32%)

  Fly   189 KRTDKRLQSLLRDSEREM-----KNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPIP 248
            :|.|.|.|.|.:....|:     :....|.:...|..:...|.|..........|    |..|.|
  Rat    53 ERADWRRQQLRKVRSVELDQLPEQPLFLTASPPCPSTSPSPEPADAAAGASGFQP----AAGPPP 113

  Fly   249 LRIASKVVESCNRY--RCVSSRPIGYRSSA---PPLAFAAQLPAGMLRSDGRATPGLGKRKDFHE 308
            ...||:    |..:  ...::|..|.||.|   ||.|               |.|. |:..:..|
  Rat   114 PGAASR----CGSHSAELAAARDSGARSPAGAEPPSA---------------AAPS-GREMENKE 158

  Fly   309 TFANLIKLGSVDRQDAKLSQEE------HTWQTELKDLIWLELQ-----------------AWQA 350
            |...|.|:.  ||.:.::.:|:      ..|:.|     |||.:                 :..:
  Rat   159 TLKGLHKMD--DRPEERMIREKLKATCMPAWKHE-----WLERRNRRGPVVVKPIPIKGDGSEMS 216

  Fly   351 DRTVEQQDKYLFEARQGVSDLLTHIINYKFQPRYRREPSLISLDSGTHSDSNS-----NASSPLP 410
            :...|.|.    |.:.|         :....|:.||.||..|..||......|     ...||:|
  Rat   217 NLAAELQG----EGQAG---------SAAPAPKGRRSPSPGSSPSGRSGKPESPGVRRKRVSPVP 268

  Fly   411 SKM----------CQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKS 465
            .:.          .....|.|     ..:|.:.|..:.|..||...:.:.|:|..:|...|..|.
  Rat   269 FQSGRITPPRRAPSPDGFSPY-----SPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKY 328

  Fly   466 QSFVGRIKSMC-------------------------LW---------------YNITKQNKLKL- 489
            :.|:|.....|                         ||               |:..:.:::|.
  Rat   329 RVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAP 393

  Fly   490 --SILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKG 552
              :.:.|.::|:.:       |.:...::.|.|||.:.:::::      :...|..:.|....:.
  Rat   394 SRNTIQKFVSRMSN-------CHTLSSSSTSTSSSENSIKDEE------EQMCPICLLGMLDEES 445

  Fly   553 VTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSH--------MRKGSMHDINIFSV 609
            :|.|               |....|:.....:|.|:.||..:.        ..|...||  .:|.
  Rat   446 LTVC---------------EDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHD--FYSH 493

  Fly   610 E---PLGTCSS------------------------------NGTGEQSTGLYRKFIENVLKSRGL 641
            |   |:.:.:|                              .|| :|....|:...|..:::.|:
  Rat   494 ELSSPVDSPTSLRGVQQPSSPQQPVAGSQRRNQESNFNLTHYGT-QQIPPAYKDLAEPWIQAFGM 557

  Fly   642 ------------AKSLAFLHKLHNV--ALYKAH------------IALEKPGAEDFDYESDAESI 680
                        .:.:|.....|:|  ||..|:            .:|....|..    |...||
  Rat   558 ELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGTSGGGSGGSLSAGAASG----SSQPSI 618

  Fly   681 EEDVPR----------LDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEF 735
            ..||..          .|| :.:..|..|:|.     .|..:    |.|.......|.||   ..
  Rat   619 SGDVVEACCSVLSIVCADP-VYKVYVAALKTL-----RAMLV----YTPCHSLAERIKLQ---RL 670

  Fly   736 LRMRLETRPV-------RPNPLSLEQLMKELREGLTLAL-THRERYQR---------HITTALVE 783
            ||..::|..|       |.:.||:..|: ||.:|....| ..||..:.         ::.:.::.
  Rat   671 LRPVVDTILVKCADANSRTSQLSISTLL-ELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILG 734

  Fly   784 NEAELGSYISILNHYDATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLISPM----- 843
            |:||..::..:|.......|...|...|:...:|...|.:.....:     .:.||:|.:
  Rat   735 NQAESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEI-----RYKKLLSLLAFALQ 794

  Fly   844 -IKGMHT----------LASQKFC----GIISKLLRSIS-------ERLVKRTVELDQQID---- 882
             |...|:          |:|.:..    .:.|||:..:|       .|:.:|.:.:..:::
  Rat   795 SIDNSHSMVGKLSRRIYLSSARMVTTVPALFSKLVTMLSASGSSHFARMRRRLMAIADEVEIAEV 859

  Fly   883 ---GTADTDDNEEVKWQLLTICR--ETQSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHD 942
               |:.||.|.::...|.|...|  |:.||                             ||..|
  Rat   860 IQLGSEDTLDGQQDSSQALAPPRYPESSSL-----------------------------EHTAH- 894

  Fly   943 VANQQHDFICSDVKAAFKLLQQDVL-----QVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLS 1002
                        |:...|.|:...|     .:.::|..:..|:....       ..||.|..|.:
  Rat   895 ------------VEKTGKGLKATRLSASSEDISDRLAGVSVGLPSSA-------TTEQPKPTVQT 940

  Fly  1003 RTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRG 1067
            :.|                                .|:                    :|.....
  Rat   941 KGR--------------------------------PHS--------------------QCLNSSP 953

  Fly  1068 MRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKK-------- 1124
            :.|               ||:.       |.|:........|...|..::..|...:
  Rat   954 LSP---------------PQLM-------FPAISAPCSSAPSVPAGSVTDASKHRPQAFVPCKIP 996

  Fly  1125 KASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHP---------------- 1173
            .|||:|::..|....|:.:..|.......|...:.|    ||.:.:..|
  Rat   997 SASPQTQRKFSLQFQRTCSENRDSEKLSPVFTQSRP----PPSSNIHRPKPSRPVPGSTSKLGDA 1057

  Fly  1174 -QFSLKEDVSGTSY-------------SPVDSSDYVDTP----CQRSANGELR-----LL---VP 1212
             :.|:..|::..|.             :.:.|.:...||    |:...|.||.     ||   :|
  Rat  1058 SKNSMTLDLNSASQCDDSFGSGSNSGGAVIPSEETAFTPAEDKCRLDVNPELNSSIEDLLEASMP 1122

  Fly  1213 QTPPTPASPGKSSLESTPLALRQERVRDAVN-------RLDMDLEDGLR----------ERRLIG 1260
            .:..|.....:.::.|...|...:..:|.||       :::.:.|:.|.          ...::.
  Rat  1123 SSDTTVTFKSEVAVLSPEKAESDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVP 1187

  Fly  1261 QVKSLNSSDKV------------HIRARSVH---FRWHRGIKIGQGRFGKVYTAVNNNTGELMAM 1310
            |::..|..|.:            |.:|:..:   ..|.:|.:||.|.|...|.|.:..||.|||:
  Rat  1188 QLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAV 1252

  Fly  1311 KEIA----IQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVE 1371
            |::.    ....:...::.:.||::::..:.|.|::|..|....:....:|:|..:.|::..|:.
  Rat  1253 KQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLS 1317

  Fly  1372 LTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTV 1436
            ..|...|::...:|.|||.|:|.||::.|:|||:|.||:.:......|::.|||:|.::.:..|.
  Rat  1318 KYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTG 1382

  Fly  1437 PGELQG-YVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPW-AQFDSN-FQIMFK 1498
            .||.|| .:||.|:|||||.   ....:||:.|:|||||.::|||..|.|| |:..|| ..::||
  Rat  1383 AGEFQGQLLGTIAFMAPEVL---RGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFK 1444

  Fly  1499 VGMG-EKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEH 1539
            :... ..|..|..||....|....||:..|:.|..:.|||:|
  Rat  1445 IASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 1486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	175/961 (18%)
		STKc_MEKK4	1281..1542	CDD:270796	91/267 (34%)
Map3k1	NP_446339.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..171		34/143 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..295		18/90 (20%)
		RING-CH-C4HC3_ZSWM2	430..485	CDD:438157	10/69 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..524		2/27 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..910		16/85 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	923..955		8/90 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	992..1060		12/71 (17%)
		STKc_MEKK1	1223..1490	CDD:270800	91/267 (34%)