DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MAP4K1

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_011524705.1	Gene:	MAP4K1 / 11184	HGNCID:	6863	Length:	873	Species:	Homo sapiens

Alignment Length:	260	Identity:	83/260 - (31%)
Similarity:	147/260 - (56%)	Gaps:	17/260 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHR 1351
            ::|.|.:|:|:.|.:..:|:|:|:|.:.::|.:.  :..:.:|:.||:..:|.|:|.|:|..:..
Human    22 RLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTCRHANIVAYHGSYLWL 84

  Fly  1352 EELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGS 1416
            ::|.|.||.|..|:|:.:.::||:|.|........::|.|::.||....:|||||.||| |::.:
Human    85 QKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANI-LINDA 148

  Fly  1417 NSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMAS 1481
            ..::|.|||.:.:|.|  |:...| .::||..:|||||.......|:....||||:|...:|:|.
Human   149 GEVRLADFGISAQIGA--TLARRL-SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAE 210

  Fly  1482 GKRPWAQFDSN-FQIMFKVGMGEKPQAPESLSQEG------HDFIDHCLQHDPKRRLTAVELLEH 1539
            .:.|  .||.: .:::|.  |.:....|..|.::|      |:||...|...||:|.:|.::|.|
Human   211 LQPP--LFDVHPLRVLFL--MTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 271

Fly 1540 1539
Human 272 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	83/260 (32%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	83/260 (32%)
MAP4K1	XP_011524705.1	STKc_MAP4K3_like	16..274	CDD:270788	83/260 (32%)
		S_TKc	17..274	CDD:214567	83/260 (32%)
		CNH	540..847	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000