DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mekk1 and MAP3K2

DIOPT Version :10

Sequence 1:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_006600.3 Gene:MAP3K2 / 10746 HGNCID:6854 Length:619 Species:Homo sapiens


Alignment Length:650 Identity:176/650 - (27%)
Similarity:262/650 - (40%) Gaps:144/650 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   930 ETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDE 994
            ::.|.|..:.|..:.....|    |:..|.:||.:.:.....|:..:|.|..:...|..:..|::
Human    78 QSMDLHYTNNELVIPLTTQD----DLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLED 138

  Fly   995 QDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVM 1059
            .|...              ||.|..|                       .|.||....      .
Human   139 LDNTV--------------FGAERKK-----------------------RLSIIGPTS------R 160

  Fly  1060 ERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKK 1124
            :|.....|..|....|      :|.:...|....:.||  :.:.||:.:..:  ..|.||    .
Human   161 DRSSPPPGYIPDELHQ------VARNGSFTSINSEGEF--IPESMDQMLDPL--SLSSPE----N 211

  Fly  1125 KASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQFS-------LKEDVS 1182
            ..|.......||....|...:|.|.:            ||.|.|   |.:||       .|....
Human   212 SGSGSCPSLDSPLDGESYPKSRMPRA------------QSYPDN---HQEFSDYDNPIFEKFGKG 261

  Fly  1183 GT-------SYSPVDSSDYVDT-PCQRSANG-ELRLLVPQTPPTPASPGKSSLES-------TPL 1231
            ||       ||...:.:|...| |..|...| .||      .|...||...||.:       || 
Human   262 GTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLR------SPVSFSPTDHSLSTSSGSSIFTP- 319

  Fly  1232 ALRQERVRDAVNRLD------MDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQ 1290
            .....|:|...:.:|      ||:....|..|                    ....|..|..:||
Human   320 EYDDSRIRRRGSDIDNPTLTVMDISPPSRSPR--------------------APTNWRLGKLLGQ 364

  Fly  1291 GRFGKVYTAVNNNTGELMAMKEIAIQPG--ETRALKNVAE-ELKILEGIKHKNLVRYYGI--EVH 1350
            |.||:||...:.:||..:|:|::...|.  ||....|..| |:::|:.:.|:.:|:|||.  :..
Human   365 GAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQ 429

  Fly  1351 REELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDG 1415
            .:.|.||||....|:::..::..|.|.|.:||::|.|:|.||..||.:.|||||||.||| |.|.
Human   430 EKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANI-LRDS 493

  Fly  1416 SNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMA 1480
            :.::||||||::.::|........::...||..:|:|||.   :.:|:||.||||||.|.||||.
Human   494 TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI---SGEGYGRKADIWSVACTVVEML 555

  Fly  1481 SGKRPWAQFDSNFQIMFKVG-MGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKY 1544
            :.|.|||:|:: ...:||:. ....|:.|..:|....||:..... :.|.|.:|.|||.|.|..|
Human   556 TEKPPWAEFEA-MAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFVHY 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mekk1NP_732373.1 MEKK4_N 105..>930 CDD:466077 175/649 (27%)
STKc_MEKK4 1281..1542 CDD:270796 101/266 (38%)
MAP3K2NP_006600.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..45
PB1_Mekk2_3 44..122 CDD:99726 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..173 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..248 14/67 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..355 17/92 (18%)
STKc_MEKK2 353..616 CDD:270818 101/268 (38%)
Blue background indicates that the domain is not in the aligned region.

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