DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and map3k4

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_002936308.2	Gene:	map3k4 / 100497217	XenbaseID:	XB-GENE-1015691	Length:	1510	Species:	Xenopus tropicalis

Alignment Length:	1680	Identity:	495/1680 - (29%)
Similarity:	743/1680 - (44%)	Gaps:	432/1680 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DELAAH--YEAFGTTPPR--TRLKIKNRDWERKQKVV-----NVTASADLPASVGGTPKKTRTAR 165
            ||.:|.  |..|.|:..|  .|:..||: |....:.|     |...|...|:....:.|.|..
Frog    21 DEASAESLYNTFPTSISRQMKRMSSKNQ-WNNTGRPVGHFTFNEKMSRPNPSPHKESSKTTGN-- 82

  Fly   166 SRVLRRNTMDCALLNEMFVNDESKRTDKRLQSLLRDSEREMKNSLATTAVAAPRGNSFHETAHPL 230
                              |.|.:.:.:|:.::.||.:||:.|.::..:.:..|...
Frog    83 ------------------VEDHNYKQEKKNRATLRMTERDQKKNVQCSFLLDPGSG--------- 120

  Fly   231 ESLDQIMPLNSEAMAPIPLRIASKVVESCNRYRCVSSRP---IGYRSSAPPLAFAAQLPAGMLRS 292
                   ||..:::..:.|                 ::|   :|..||..|::....|.....:|
Frog   121 -------PLTKKSIPDVDL-----------------NKPYLSLGCSSSKLPVSVPVSLARTTRQS 161

  Fly   293 DGRATPGLGKRKDFHETFANLIKLGSVDRQDAKLSQ-EEHT---WQTELKDLIWLELQAWQADRT 353
            .....|  ..|..|.||...|:||.||.::..:..: :|:|   ...:..:|.|||||||.|.|:
Frog   162 SRTDCP--ADRLKFFETLRLLLKLTSVSKKKEREQRGQENTSSMGYNQSNELFWLELQAWHAGRS 224

  Fly   354 VEQQDKYLFEARQGVSDLLTHIINYK------------FQPRYRREPSLISLDSGTHSDSNSNAS 406
            :..||.||:.|||.:.|::..|:.:|            ....:|..|.::|
Frog   225 INDQDLYLYTARQTIPDIINEILTFKVNYGSLFSDADNINGTFRERPFIVS-------------- 275

  Fly   407 SPLPSKMCQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGR 471
               |.....|..|.:  :.:..|:::..:|:.::..||..||||||..|:...:..|.::.|..|
Frog   276 ---PGSFAFGHSSYH--EHIQKQKISFEQVKQIMDLLEYIEALYPSLNALQRDYEKYAAKDFQAR 335

  Fly   472 IKSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPV------CTSSYIATDSGSSSASGV---- 526
            ::::|||.||||....||.|:|.:|.........|||      |.|:....:..:....|.
Frog   336 VQALCLWLNITKDLNHKLRIMGSVLGIKNLSNIGWPVFEISSPCPSNCPEDEHDNIEHEGQIHDG 400

  Fly   527 ---------ENDDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNE---- 578
                     |.::..:|::|           .|:.......|.|...|       .||||:
Frog   401 APRMCREEREEEELTINNLD-----------LRQDFNSKLTVNFFEED-------YSSSNKLDKI 447

  Fly   579 STSTEVSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAK 643
            .:..:.|..:.||:.|...:   |            |        ||.:||.|::..||..||.|
Frog   448 MSEDDFSWGNPECNDSDCNR---H------------C--------STSIYRPFVDKALKQMGLRK 489

  Fly   644 SLAFLHKLHNVALYKAHIALEKPGAE-DF----------DYESD-----AESIEEDVPRLDPEIS 692
            .:..||||.:.:|.:|..||...... ||          ||..|     ..:::...|..|| :|
Frog   490 LILRLHKLMHGSLQRARRALMMADRTFDFSEYPDLMLCSDYLPDLLKQSRSTVQSSEPACDP-VS 553

  Fly   693 REQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETRPV-RPNPLSLEQLM 756
                        | ||.:|::|||::|.|:.|..:.|..:||.|::|||.||. .|:.||::||:
Frog   554 ------------W-EELKSMDLPSFLPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLV 605

  Fly   757 KELREGLTLALTHRERYQ---RHITTALVENEAELGSYISILNHYDATVRKTFELYLEYIDQLV- 817
            :|.:|.|...|..::.||   |.:...|.:.:.::.|       ::..:.|...:|.:|:...:
Frog   606 RECKEVLKGGLLMKQYYQFMLREVLDDLQKLDCDIDS-------FEDDLHKMLMVYFDYMRSWIQ 663

  Fly   818 -LVAVPEGNQ--KSVLEKEWMFTKLISPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQ 879
             |..:|:.:.  |::||:||.|||.|:|:|:|....|.:.||.|...||:|..:.|....  ||.
Frog   664 MLQQLPQASHSLKNLLEEEWNFTKEITPLIRGGEAQAGKLFCDIAGMLLKSTGKFLDSGL--LDS 726

  Fly   880 QIDGTADTDD---NEEVKWQLLTICRETQSLLTVERERSIKVLFFAK------------TF---- 925
            ..:..|.|||   ::|::..::...|..:.|....|||:.|.|.|||            ||
Frog   727 CDEFWASTDDSSISDEIRRSVIETSRALKELFHEARERASKALGFAKMLRKDLEIAAEFTFASTI 791

  Fly   926 -----------------------------------------------------CRD--------- 928
                                                                 |.|
Frog   792 LELLAFLKAKDYAKVLIPSVENLHVFIPGNLSREKIIVQQLLGTAAGIDCSKDCEDMAYDQFLLM 856

  Fly   929 --------------------------VETTD---------------------FHREHYEHDV--- 943
                                      |||.|                     ..|:.::|..
Frog   857 TKHIDKDKPQEDWNSWDGCCIKSMPPVETADTLRSMQTDNLLLVVMQSAHLQSQRKAFQHSTEGL 921

  Fly   944 ------ANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLS 1002
                  ....|..|   .:|.|: |:.:.||:.|::::.|:.|.|.....:..::||.:...:..
Frog   922 LSLRLEQTSSHPMI---AEALFQ-LKSEALQLCNEISSAIDRVDKMFTNESEAEIDESESSTLQQ 982

  Fly  1003 RTREILHQGYKFGFEYHKDVIRL----FEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCE 1063
            ..||.:.|||.|||||||:|:||    |.||..|:             .|.:|:.||:||:.:||
Frog   983 YYREAMIQGYNFGFEYHKEVVRLMSGEFRQKTGDK-------------YINFARKWMNFVLTKCE 1034

  Fly  1064 RGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEK---VAKKK 1125
            .|||.|||||:||.::| .|.:|.....|.:|:|.:|:..|:.||.||||....|..   :|..:
Frog  1035 SGRGTRPRWATQGFDYL-QAIEPVFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYIATHR 1098

  Fly  1126 ASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPN--TPPLQS------PPYNKLLHPQFSLKEDVS 1182
            .|||              |.:.|.......|||  ||..:.      |..::|......|:....
Frog  1099 NSPR--------------PVKVPRCHSDPPNPNLITPTPEGFRGSSVPENDRLASVASELQFRSL 1149

  Fly  1183 GTSYSPVDSSDYVDTP-------CQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVRD 1240
            ....||.:..:....|       .:||  .||:..:.||....|       ...|:...||.|:
Frog  1150 SRHSSPTEDREEPSYPKGELWGSTRRS--WELQTFISQTRDIAA-------RHRPMNAIQESVK- 1204

  Fly  1241 AVNRLDMDLED----GLRERRLIGQV-KSLNSSDKV-HIRARSVHFRWHRGIKIGQGRFGKVYTA 1299
                   ..||    .:|.:.::||| .:..|.|.| |:..|.|.|:|.||.|||:|::|||||.
Frog  1205 -------QFEDERYRQMRNKNIVGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC 1262

  Fly  1300 VNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEG 1364
            ::.:||||||||||..||.:.:.:|..|:||||.|||||.|||||:|:|:||||:.||||.|.||
Frog  1263 ISIDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEG 1327

  Fly  1365 TLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVK 1429
            |||.:..|  .|.|.:.|.:|.|:...::.||:|||||||||.|||||. .|..:||||||.:||
Frog  1328 TLEEVSRL--GLQEHVIRLYTKQITIAINVLHEHGIVHRDIKGANIFLT-SSGLIKLGDFGCSVK 1389

  Fly  1430 IQAHT-TVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNF 1493
            ::.:. |:|||:...:||.|||||||.|:...:||||||||||:|||::||.:|||||.:::.||
Frog  1390 LKNNAQTMPGEVNSTLGTAAYMAPEVITQAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNF 1454

  Fly  1494 QIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDE 1548
            |||::||||.||..|:.||.||.||:.||.:.|||.|.||.:||:|.|.|...||
Frog  1455 QIMYRVGMGHKPPIPDRLSPEGKDFLSHCQESDPKMRWTASQLLDHAFVKVCTDE 1509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	150/261 (57%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	150/259 (58%)
map3k4	XP_002936308.2	STKc_MEKK4	1244..1503	CDD:270796	150/261 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31346
Inparanoid	1	1.050	646	1.000	Inparanoid score	I794
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	1	1.000	-	-		FOG0002637
OrthoInspector	1	1.000	-	-		otm47473
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2354
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060