Protein Alignment Mekk1 and map3k3

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_031750734.1
• Gene: map3k3 / 100490021
• XenbaseID: XB-GENE-986927
• Length: 625
• Species: Xenopus tropicalis
• Alignment Length: 663
• Identity: 175/663 - (26%)
• Similarity: 302/663 - (45%)
• Gaps: 115/663 - (17%)

  Fly   954 DVKAAFKLLQQDVLQV----RNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKF 1014
            |.:.|.|.:.:|::.:    |:::.. ||.|:.:|.:...:..|.:.|         ..|.|.:.
 Frog     2 DEQEALKSIMKDLVALQMGRRHRIPG-IEAVKTKCSIQPNKQTDVRIK---------FEHSGERR 56

  Fly  1015 GFEYHKDV-IRLFEQKIMDQKDSGAHTVDL-----ALGIIAYAKMWMHFVMERCERGRGMRPRWA 1073
            ..::.:.| ....|||:   |:.....:||     .|.|...::..:...::..:|...|:
 Frog    57 ILQFSRPVKFEEVEQKV---KNVFGQQLDLYYMNNELSIPLRSQDDLDKAVDLLDRSSSMK---- 114

  Fly  1074 SQGLEFLILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTS--SP 1136
              .|..|:|:.|   ..|:.... ..:::|:....|..:|..|    .....|.||:|..|  |.
 Frog   115 --SLRILLLSHD---KNHISSSH-SGIQKQVRIKASQSVGDIS----TVYHPAEPRSRHLSVTSQ 169

  Fly  1137 ATSRSR-----TPTRTPMSA--GMVLNPNTPPLQSPPYNK--LLHPQFSLKEDVSGTSYSPVDSS 1192
            .|.||.     .|.|....|  |...:.|:.....|..|:  .|.|..|.:..:||:..| :|.|
 Frog   170 NTGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETNEQCALDPLSSTENSISGSCQS-LDQS 233

  Fly  1193 DYVDTPCQRSANGELRLLVPQTPP--------------TPASPGKSSLESTPLALRQERVRD--- 1240
            :  |:|..|.:    |:...|:.|              ..|..|.:......::::.:...|
 Frog   234 E--DSPSFRKS----RMSRAQSYPDNRQDFSDRENQFSDRAGKGGTYPRRYHVSIQHKEYNDGRR 292

  Fly  1241 ----------------------AVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVH---- 1279
                                  :.|..::.|.....|.|  |::::.:|.:.:.::.|::.
 Frog   293 TFPRIRRPQGNLFTLVPSSRSLSTNGENLGLTVQYMENR--GRLRNADSENTLTVQERNISSKSP 355

  Fly  1280 ---FRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAE---ELKILEGIKH 1338
               ..|.||..:|||.||:||...:.:||..:|.|::...|......|.|:.   |:::|:.:.|
 Frog   356 SAPINWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHH 420

  Fly  1339 KNLVRYYGI--EVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIV 1401
            ..:|:|||.  :...:.|.||||....|:::..::..|.|.|.:|||:|.|:|.|||.||.:.||
 Frog   421 DRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIV 485

  Fly  1402 HRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRA 1466
            |||||.||| |.|.:.::||||||::.::|........::...||..:|:|||.   :.:|:||.
 Frog   486 HRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI---SGEGYGRK 546

  Fly  1467 ADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG-MGEKPQAPESLSQEGHDFIDHCLQHDPKRR 1530
            ||:||:||.||||.:.|.|||:::: ...:||:. ....||.|.:.|::..||:...|. :.::|
 Frog   547 ADVWSLGCTVVEMLTEKPPWAEYEA-MAAIFKIATQPTNPQLPPNTSEQCRDFVKRILV-EARQR 609

  Fly  1531 LTAVELLEHNFCK 1543
            .||.||:.|.|.:
 Frog   610 PTAEELIRHPFAQ 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077
		STKc_MEKK4	1281..1542	CDD:270796	101/266 (38%)
map3k3	XP_031750734.1	PB1_Mekk2_3	45..122	CDD:99726	16/94 (17%)
		STKc_MEKK3_like	360..620	CDD:270795	101/265 (38%)