Protein Alignment Mekk1 and map3k19

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_002941471.3
• Gene: map3k19 / 100488738
• XenbaseID: XB-GENE-6046272
• Length: 1285
• Species: Xenopus tropicalis
• Alignment Length: 1361
• Identity: 244/1361 - (17%)
• Similarity: 423/1361 - (31%)
• Gaps: 501/1361 - (36%)

  Fly   224 HETAHPLESLDQIMPLNSEAMAPIPLRIASKVVESCNRYRCVSSRPIGYRSSAPPLAFAAQLPAG 288
            |.|.|.:|.:|:         ||..|:  ..:....|.....:...:.|..|.     .|.||..
 Frog   283 HTTLHEMEGVDR---------APDILK--GSLARLWNSNSLPNDITLMYNPSR-----HASLPPF 331

  Fly   289 MLRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDAKLSQEEHTWQTELKDLIWLELQAWQADRT 353
            .||:|..|              |.:..||.     ..|.|..|:     :..|...|:.....|.
 Frog   332 PLRNDCHA--------------AQMDSLGL-----GYLCQSSHS-----EPNISASLRGTDLLRD 372

  Fly   354 VEQQDKYLFEARQGVSDLLTHIINYKFQPRYRREPSLISL----------DSGTHSDSNSNASSP 408
            ::       ..:|.::..||...|:...|...:.|..:.|          .:|:....|...|.|
 Frog   373 IK-------GVKQHITQRLTSPRNHTPSPLLCQSPRAVRLTPLVMDTPRGKAGSDISVNDLVSLP 430

  Fly   409 L--------PSKMCQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEALYPSSQAMGALHPIYKS 465
            :        |.|:|.|                               ..|.::....|.| |...
 Frog   431 ISDAFAKSAPHKLCSG-------------------------------NKYSNNSPSPAPH-IAGD 463

  Fly   466 QSFVGRIKSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVENDD 530
            |              :..:|::.||:         ||.|        .|:.:....:|.|
 Frog   464 Q--------------VLSKNQIYLSM---------DESF--------IISEEEQGLAAPG----- 492

  Fly   531 SAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSH 595
             ||.:.:|::..|:...|.      |.:...:|           |..:..|||:.|     |...
 Frog   493 -AVGNSESNRKESLFVQAK------CKRTAKIL-----------SVFQGGSTELHQ-----SERT 534

  Fly   596 MRKGSMHDINIFSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAH 660
            |.|.....||                 ||.    |: :|:|.:| |::...|:.|..:..|..|.
 Frog   535 MTKRHEEGIN-----------------QSP----KW-DNILSAR-LSQRENFVGKAVSADLIIAT 576

  Fly   661 I--ALEKPGAEDFDYESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPS------Y 717
            .  .:|.......|.:...|.:|...|....:..::..:.|....:..:..||:...|      :
 Frog   577 STETMENVSEIQEDIDDKREPLEGKDPGNSMQTPQDGQLPLVHITFSEQGPQSLKAKSPPLKQFF 641

  Fly   718 IPTFVFLSGIPLQFMHEF-----------------------------------LRMRLETRPVRP 747
            :.....|.|:|....|.|                                   :...:..:.|..
 Frog   642 MKRKTILCGVPHNVNHSFNVIAQKENEKGKKNRKSRTKSACDAPSKQKQKPLSINKNMNIKSVPL 706

  Fly   748 NPLSLEQLMKELREGLTLALTHR-------ERYQRHITTALVENEAEL-------------GSYI 792
            .||.|....|.||....:..:|.       ||...|::....:|.:.:             ..:.
 Frog   707 PPLELTGSTKRLRTPQKVPHSHLPGSDKGVERSNTHLSMCPKKNNSPVVTTRHPLTRANTAPDFT 771

  Fly   793 SILNHYDATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLISPM-IKG-----MHTLA 851
            ||..|   .:.|..|...|..:...:|.:|            ::.:...|: :.|     .|:..
 Frog   772 SITYH---DIFKKLEANNEGPEIYEMVVMP------------LYPQTGDPVDVSGSVCRESHSAM 821

  Fly   852 SQKFCGIISKLLRSI-----------------SERLVKRTVELDQQIDG-TADTDDNEEVK---- 894
            |:|  |..||:.||.                 |:|...|:....:.:|. ..|....|:|:
 Frog   822 SKK--GSSSKVARSSSANESNRRRKPKRPNSKSKRCASRSSLKHKNLDARDEDCAIEEKVEHGVI 884

  Fly   895 ------WQLLTICRETQSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICS 953
                  ||::              |:|..:||.:|      |:.....|.::.::.::.    .|
 Frog   885 VISGTDWQII--------------EKSNNILFDSK------ESVAVVLEPFQDNIYHED----LS 925

  Fly   954 DVKAAFKLLQQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEY 1018
            .:|.|         .:.|.|..                          |||             :
 Frog   926 MIKEA---------TIENSLNT--------------------------SRT-------------F 942

  Fly  1019 HKDVIRLFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILA 1083
            |.|.:          |.||.                             |.|
 Frog   943 HDDRV----------KGSGE-----------------------------MNP------------- 955

  Fly  1084 CDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTP 1148
                  .|.|.:.|                |..:|.|......|.:....||.|........:..
 Frog   956 ------NHFDAEVF----------------IQEQPIKSVPSTDSHKRETRSSSAQQEELEDYKVD 998

  Fly  1149 MSAGM--VLNPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLV 1211
            .:.|:  ..|.|..|                :|...|.:.:....|..:.|      .|::..|.
 Frog   999 NTGGVPSCENKNNAP----------------RETTEGGTENGYGFSKSLST------EGDIEQLT 1041

  Fly  1212 PQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGL---RERRLIGQV-----KSLNSS 1268
            ...        ...|....|::.:...:|::..::.|.:|.:   ::::.....     ||.|::
 Frog  1042 DDL--------IHCLVENLLSIDERESQDSIESINTDTDDEIMNDQDQKCKSPSHNECNKSANTT 1098

  Fly  1269 --DKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGE----TRALKNVA 1327
              ||:...:.:..|.|.:|..:|:|.:|.||..:.:. |||:|.|::.:...:    .:..|.:.
 Frog  1099 NIDKLADSSINGSFPWTKGEVLGKGAYGTVYCGLTSQ-GELIAAKQVVLDSSDPVTAQKEYKKLQ 1162

  Fly  1328 EELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGV 1392
            ||:.:|:.:.|.|:|.|.|.......:.||||....|::.|::...|.|.|.:..::|.|:|.|:
 Frog  1163 EEVDLLKALDHVNIVGYLGTCREDNMVTIFMEFVPGGSIASILRRFGPLQEMVFIKYTKQILQGI 1227

  Fly  1393 SELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYV---GTQAYM 1450
            ..||.:.::|||||..|:.|:. :..:||.|||.|.::.           |:   |||:.|
 Frog  1228 VYLHSNRVIHRDIKGNNLMLMP-NGIIKLIDFGCAKRLT-----------YLNKSGTQSEM 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	142/820 (17%)
		STKc_MEKK4	1281..1542	CDD:270796	54/177 (31%)
map3k19	XP_002941471.3	ANKYR	1..>184	CDD:440430
		ANK repeat	38..68	CDD:293786
		ANK repeat	70..128	CDD:293786
		ANK repeat	130..174	CDD:293786
		Protein Kinases, catalytic domain	1112..>1285	CDD:473864	55/178 (31%)