DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and map3k1

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_005155564.1	Gene:	map3k1 / 100334486	ZFINID:	ZDB-GENE-090313-412	Length:	1479	Species:	Danio rerio

Alignment Length:	1683	Identity:	343/1683 - (20%)
Similarity:	587/1683 - (34%)	Gaps:	506/1683 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 GTTPPRTRLKIK-----NRDWERKQKVVNVTASADLPASVGGT----------PKKTRTARSRVL 169
            |:|......|:|     :..|.||.:      |.||.....||          |...:||   :|
Zfish    33 GSTSQNNSGKVKRNAGESSQWRRKVR------SVDLDKCESGTAALHFLTVSGPGSIQTA---LL 88

  Fly   170 RRNTMDCALLNEMFVNDESKRTDKRLQSLLRDSEREMKNSL---------------ATTAVAAPR 219
            :::..|..|            .||...:|...::..||:||               |...|.|.:
Zfish    89 QQSLADPPL------------GDKISNNLCTSAQEWMKSSLKSGSESPSAEHGGAAAAVDVNASQ 141

  Fly   220 GNSFHETAHPLESLDQI-----------------MPL-NSE-----------AMAPIPLRIASKV 255
            .:...|....|..|.::                 ||. .||           .:.||||| |...
Zfish   142 NSRDMENKETLRGLQKMEDRPEERLIREKLKATCMPTWKSEWLERRSRRGPMVVKPIPLR-ADGT 205

  Fly   256 VESCNRYRCVSSRPIGYRSSAP-PLAFAAQLPAGMLRSDGRA----TPGLGKRKDFHETFANLIK 315
            ....:.:...||:..|.||.:| |.:|:|...:....|...|    :|||.:|:      |:.:.
Zfish   206 EAGSDSHNSSSSQSRGQRSPSPGPSSFSAASSSSSSSSTKTAGKPDSPGLRRRR------ASPVP 264

  Fly   316 LGSVDRQD--------AKLSQEEHTWQ-------------------------------------- 334
            .|.|....        :..|.||.:.:
Zfish   265 SGRVTPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKFRVFIGPQ 329

  Fly   335 -------TELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSDLLTHIINYKFQPRYRREPS--- 389
                   |....::::.|:.:|    :|..|..|:.     ..|....:...||..:.|..|
Zfish   330 TCSCGRGTFCIHVLFVMLRVFQ----LEPSDPLLWR-----KTLKNFEVESLFQKYHNRRSSRIK 385

  Fly   390 ---------LISLDSGTHSDSNSNASSPLPS-----------KMCQGCMSLYCKDCMDHQELALR 434
                     .:|..|.:|:...|:||   ||           :||..|:    .|.:|.:.|.:.
Zfish   386 APSRSTIQKFVSRMSNSHTSCTSSAS---PSSNESSMKDEEEQMCPICL----LDMLDEESLTVC 443

  Fly   435 EVEGMLTRLEAAEALYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNITKQNKLKLSILGKILARL 499
            | ||...:|.               |            ..|.:|....::|
Zfish   444 E-EGCRNKLH---------------H------------HCMSIWAEECRRN-------------- 466

  Fly   500 QDEKFSWPVCTS--------SYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKG---- 552
             .:....|:|.:        ||.|..:..|:.|..::..:|.:|..||   |:...:||.|
Zfish   467 -HDPLICPLCRAKWKPHDFYSYEAPSTVESTTSRSQSQTAASSSSSSS---SLHAESSRTGQDGD 527

  Fly   553 -VTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQ-WSSECSHSHMRKGSMHDINIFSVEPLGTC 615
             ..|.:.||       |:|        .|.||::: |                |.:|.:|.:|..
Zfish   528 FSLPQYGVQ-------HIP--------QTYTELAEPW----------------IKVFGLELVGCL 561

  Fly   616 SSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESI 680
            .|.....:...|.|       .|..::.:|...:..|::|...|...|.:... |...||....:
Zfish   562 FSRNWNIREMALRR-------LSHDVSGALLLANGEHSLAGAGAGAGLAEVSG-DVVVESCCSVL 618

  Fly   681 EEDVPRLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHEFLRMRLETRPV 745
              .:...|| :.:..|..|:|.     .|..:..|.:       |......:.:.||..:||..|
Zfish   619 --SMVCADP-VYKVYVAALKTL-----RAMLVYTPCH-------SASERTRLQQLLRPVVETILV 668

  Fly   746 -------RPNPLSLEQLMKELREGLTLALTHRERYQR---------HITTALVENEAELGSYISI 794
                   |.:.||:..|::..:..:......||..:.         ::...::.::.|..::.::
Zfish   669 KCADANSRTSQLSVSTLLELCKGQMGELAVGREILKAGSIGIGGVDYVLNCILGSKTEANNWQAL 733

  Fly   795 LNHYDATVRKTFELYLEYIDQLVLVAVPEGNQ-KSVLEKEWMFTKLISPMIKGMHTLASQKFCGI 858
            |.......|...|...|:...  :|:..:.|| ::|:|:......|:|..:|.:..  |....|.
Zfish   734 LGRLCLIDRLLLEFPAEFYPH--IVSGGDCNQAQNVVERYQKLLPLLSFALKSIDN--SHSMVGK 794

  Fly   859 ISKLLRSISERLVKRT----VELDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERSIKVL 919
            :|:.:...:.|:|.|.    |:|...::.|:.| ....::.:||.|..|...|..:.
Zfish   795 LSRRVFLSAARMVARVPHVFVKLLDMLNVTSST-HYARMRRRLLAIAEEMDILDAIH-------- 850

  Fly   920 FFAKTFCRDVETTDFHREHYEHDVA----NQQHDFICSDVKAA-FKLLQQDVLQVR---NKLTAI 976
                     :...|..:||.....|    :..|:..|:..::: ...|||...:|.   ...:..
Zfish   851 ---------LGLDDLQKEHTSPSCAFLEPSAPHNSPCTTERSSPTHGLQQPAAKVALSGQASSTP 906

  Fly   977 IEGVQKRCCLSN-MRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHT 1040
            :|.:.:|  ||| :....|..|..:.:|.|.:                    .:.::...||...
Zfish   907 VEDITER--LSNIVASPAEFPKPPIQARNRPV--------------------SQCLNSPSSGQPP 949

  Fly  1041 VDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQ----ITQHLDDDEF---- 1097
               :|..::.|.                    ||        |..|:    :.|.....:|
Zfish   950 ---SLPSLSMAN--------------------AS--------AFPPENPKALPQSFIPSKFAQSS 983

  Fly  1098 ----EALKQQMDRCISHVIGITSEPEKVAK---KKASP-------RTRKT-SSPATSRSRTPTRT 1147
                ..|..|...|.|      .||||:..   .:|.|       |.|.: .:||.|.......:
Zfish   984 LGSQRKLPLQKGACSS------KEPEKLPSPVFTQARPLPQSQIHRPRPSRPTPAASSDGAKALS 1042

  Fly  1148 PMSAGMVLNPNTPPLQSPPYNKLLHPQFSLKEDV--SGTSYSPVDSSDYVDTPCQRSANG----- 1205
            |::.|.:              ||...:...::||  ||.| :.:.|.|...||.:...:|
Zfish  1043 PLTKGNM--------------KLDLQEARSRDDVACSGGS-ALIPSEDTAFTPVEEKFHGLDASA 1092

  Fly  1206 ----ELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERR--------- 1257
                .:..|:..:.|...|......|...|:..|....|.....|:......:|:.
Zfish  1093 DLSSSMEDLLEASIPAADSTVTFQSEVAVLSPEQANANDDTYSEDVTQNQKCKEKMEAEEEEALA 1157

  Fly  1258 -------------LIGQVKSLNSSDKV------------HIRARSVH---FRWHRGIKIGQGRFG 1294
                         :|.|::.....|.:            |.:|:..:   ..|.:|.:||.|.|.
Zfish  1158 VVMAMSESQDALPVIPQLQVDKGEDVIIIQVDTPETLPGHTKAKQPYREGNEWLKGQQIGLGAFS 1222

  Fly  1295 KVYTAVNNNTGELMAMKEIA----IQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELL 1355
            ..|.|.:..||.|||:|::.    ....:...::.:.||::::..:.|.:::|..|....:....
Zfish  1223 SCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGLLNHPHIIRMLGATCEKNNYN 1287

  Fly  1356 IFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLK 1420
            :|:|..:.|::..|:...|...|.:...:|.|||.|::.||::.|:|||||.||:.:......|:
Zfish  1288 LFVEWMAGGSVSHLLNKYGAFKEGVIINYTEQLLRGLAYLHENQIIHRDIKGANLLIDSTGQRLR 1352

  Fly  1421 LGDFGSAVKIQAHTTVPGELQG-YVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKR 1484
            :.|||:|.::.:..|..||.|| .:||.|:|||||.   ....:||:.|:|||||.::||:..|.
Zfish  1353 IADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL---RGQQYGRSCDVWSVGCAIIEMSCAKP 1414

  Fly  1485 PW-AQFDSN-FQIMFKVGMG-EKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEH 1539
            || |:..|| ..::||:... ..|..|..||....|....||:..|..|..:.|||:|
Zfish  1415 PWNAEKHSNHLALIFKIASATTAPSIPPHLSPGLRDVTLRCLELQPTDRPPSRELLKH 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	89/267 (33%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	89/266 (33%)
map3k1	XP_005155564.1	STKc_MEKK1	1209..1476	CDD:270800	89/267 (33%)
map3k1	XP_005155564.1	S_TKc	1210..1475	CDD:214567	89/266 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910