DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MEP1B and tld

DIOPT Version :9

Sequence 1:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens
Sequence 2:	NP_524487.2	Gene:	tld / 42945	FlyBaseID:	FBgn0003719	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	178/811 - (21%)
Similarity:	267/811 - (32%)	Gaps:	291/811 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    61 RNSIIGEKYR-WPH-TIPYVLEDSLEMNAKGVILNAFERYRLKTCIDF--KPWAGETNYI-SVFK 120
            |.::...|.| |.: .|||.::.......|.:...|...:...|||.|  :......||| ...|
  Fly   135 RRAVTVRKERTWDYGVIPYEIDTIFSGAHKALFKQAMRHWENFTCIKFVERDPNLHANYIYFTVK 199

Human   121 GSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGRE 185
            ..||.|.:|....|:|.:|||.||::...:.||..|.:||.||.:|.|||.::.|....|:.|:|
  Fly   200 NCGCCSFLGKNGNGRQPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQE 264

Human   186 HNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRI-----SDFEDVIGQRMDFSDSD 245
            :||:..|.:..|...:|||..|:|||:|.:|........:|.|     :..|  :|||...|..|
  Fly   265 YNFDVLSPEEVDLPLLPYDLNSIMHYAKNSFSKSPYLDTITPIGIPPGTHLE--LGQRKRLSRGD 327

Human   246 LLKLNQLYNCSSSLSFMDSCSFELENVCGMI--QSSGDNADWQRVSQVPRGPESDHSNMGQCQGS 308
            :::.|.||.|:|               ||..  |:||....       |....|.:..:.:.:||
  Fly   328 IVQANLLYKCAS---------------CGRTYQQNSGHIVS-------PHFIYSGNGVLSEFEGS 370

Human   309 G-------FFMHFDSSSVNV--------GATAVLESRTLYPKRGFQCLQFYLY------------ 346
            |       ....||:|..|.        |...:|..:.|:......|.|.||.
  Fly   371 GDAGEDPSAESEFDASLTNCEWRITATNGEKVILHLQQLHLMSSDDCTQDYLEIRDGYWHKSPLV 435

Human   347 -----NSGSE------SDQLNIYIREYSADN-----------VDGNLTLVEEIKEIPTGSWQL-- 387
                 |...|      |..|..|:...:|..           ..|:|.|.:: :.|.:.::.:
  Fly   436 RRICGNVSGEVITTQTSRMLLNYVNRNAAKGYRGFKARFEVVCGGDLKLTKD-QSIDSPNYPMDY 499

Human   388 -------YHVTL----KVTKKFRVVFEGRKGSGASLGGLSIDDINLSETR-----C----PHHI- 431
                   :.:|.    :|..||: .||..|..|.:...:.|.|.|.|::|     |    |.:|
  Fly   500 MPDKECVWRITAPDNHQVALKFQ-SFELEKHDGCAYDFVEIRDGNHSDSRLIGRFCGDKLPPNIK 563

Human   432 -----WHIR-----------------------NFTQF---------IGS---------------- 443
                 .:||                       .||..         :||
  Fly   564 TRSNQMYIRFVSDSSVQKLGFSAALMLDVDECKFTDHGCQHLCINTLGSYQCGCRAGYELQANGK 628

Human   444 --------------PNGTLYSPPF---Y-SSKGYAFQ--------IYLNLAHVTNAGIYFHLISG 482
                          .||:||||.:   | :||...::        ::||.:|....|..|| .:.
  Fly   629 TCEDACGGVVDATKSNGSLYSPSYPDVYPNSKQCVWEVVAPPNHAVFLNFSHFDLEGTRFH-YTK 692

Human   483 ANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSN 547
            .|.|.|                  .|..:|             .||      |..|:|
  Fly   693 CNYDYL------------------IIYSKM-------------RDN------RLKKIG------- 713

Human   548 GTQFRRGGGYGTSAFITHER---LKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCS 609
                         .:..||.   :.|...|...:.|...||:....:....|.:       |.||
  Fly   714 -------------IYCGHELPPVVNSEQSILRLEFYSDRTVQRSGFVAKFVIDV-------DECS 758

Human   610 KTTCKNDGVCTVR----DGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSSTVAVFALMLII 670
                .|:|.|..|    .|..:|.|::|......|..|.:   ||....|..|
  Fly   759 ----MNNGGCQHRCRNTFGSYQCSCRNGYTLAENGHNCTE---TRCKFEITTS------------ 804

Human   671 TLVSVYCTRKKYRERMSSNRPNLTPQNQHAF 701
                       |....|.|.|...|:|.:.:
  Fly   805 -----------YGVLQSPNYPEDYPRNIYCY 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	67/203 (33%)
		Astacin	69..257	CDD:279708	66/197 (34%)
		MAM	260..427	CDD:214533	44/235 (19%)
		MAM	265..427	CDD:99706	44/230 (19%)
		MATH	427..586	CDD:295307	40/245 (16%)
		Required for proteolytic processing	595..607		1/11 (9%)
tld	NP_524487.2	ZnMc_BMP1_TLD	137..338	CDD:239808	66/202 (33%)
		Astacin	144..339	CDD:279708	66/196 (34%)
		CUB	388..474	CDD:214483	14/85 (16%)
		CUB	478..586	CDD:278839	22/109 (20%)
		FXa_inhibition	595..630	CDD:291342	4/34 (12%)
		CUB	634..750	CDD:278839	32/173 (18%)
		FXa_inhibition	757..792	CDD:291342	11/38 (29%)
		CUB	797..906	CDD:278839	8/51 (16%)
		CUB	910..1023	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810