DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and Crot

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_038964380.1	Gene:	Crot / 83842	RGDID:	70908	Length:	752	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	198/733 - (27%)
Similarity:	336/733 - (45%)	Gaps:	134/733 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LRSFSIGSGPNSPQRVVSNLRGFLTHRLSNITPSDTGWKDSILSIPKKWLS---------TAESV 79
            ::.|..|.|....|:::...:|                       .:.|.|         .|:|:
  Rat   108 VQKFQDGVGKTLHQKLLERAKG-----------------------KRNWFSYCDYTMENQLAKSI 149

  Fly    80 DE--FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLD 142
            :|  |.:.|:||.:|||:|:|::..|:.:::|.....:.::|:|::::|.  .|:|..|||.||:
  Rat   150 EERTFQYQDSLPPLPVPSLEESLKKYLESVKPFANEDEYKKTEEIVQKFQ--DGVGKTLHQKLLE 212

  Fly   143 KREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAAR----------LLD 197
            :.:.:.||...:|||..|:|:|||..:|.|  .|.|...|:  |   ::.||          ||.
  Rat   213 RAKGKRNWLEEWWLNVAYLDVRIPSQLNVN--FVGPSPHFE--H---YWPAREGTQLERGSILLW 270

  Fly   198 GILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDR-- 260
            ..|::.::|...:||:.::.    |.||.|.|:..|..:|:.||:.:||  :.:..:...|..
  Rat   271 HNLNYWQLLRREKLPVHKSG----NTPLDMNQFRMLFSTCKVPGITRDS--IMNYFKTESEGHCP 329

  Fly   261 -HVVVICRNQMYCV-VLQASDRGKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARD 323
             |:.|:||.:.:.. ||.  |...::..|:..|:.|:.......|..| .:..||:|.|:.||:.
  Rat   330 THIAVLCRGRAFVFDVLH--DGCLITPPELLRQLTYIYQKCWNEPVGP-SIAALTSEERTRWAKA 391

  Fly   324 RE-MLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHG 387
            || ::..|..|...||.|:::..|..:::.         ...|||        :..:...||:.|
  Rat   392 REYLIGLDPENLTLLEKIQSSLFVYSIEDT---------SPHATP--------ENFSQVFEMLLG 439

  Fly   388 GGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYKKIEEHPDEDNGLPQ-H 451
            |    :...||.||:..||...:|.:|...:|:..:.:.:|.:...:.:|:.|......|..: .
  Rat   440 G----DPAVRWGDKSYNLISFANGIFGCSCDHAPYDAMVMVNIAHYVDEKLLETEGRWKGSEKVR 500

  Fly   452 HLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQ 516
            .:|.||.|.:.|..::.....||.....|...||......:.|:||...|...:.||.:||||||
  Rat   501 DIPLPEELAFTVDEKILNDVYQAKAQHLKAASDLQIAASTFTSFGKKLTKKEALHPDTFIQLALQ 565

  Fly   517 LAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESR 581
            ||:|:|:||....||:|.||.|.|||.:.:|:.:.||:.|.::| |...|:: ||..::..:
  Rat   566 LAYYRLHGRPGCCYETAMTRYFYHGRTETVRSCTVEAVRWCQSM-QDPSASL-LERQQKMLD--- 625

  Fly   582 KVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYII 646
                              |.|:..::|.....|.|.|..||||...:.|....:.|||:|..:..
  Rat   626 ------------------AFAKHNKMMRDCSHGKGFDRHLLGLLLIAKEEGLPVPELFEDPLFSR 672

  Fly   647 S---QCFLLSTSQVACSTDSFMGY----GPVTP---RGYGCSYNPHPEQIVFCVSAFYSCEDTSA 701
            |   ..|:||||.|        ||    |.|.|   .|||..|:...::.|...|::.||.:|.|
  Rat   673 SGGGGNFVLSTSLV--------GYLRIQGVVVPMVHNGYGFFYHIRDDRFVVTCSSWRSCLETDA 729

  Fly   702 SRYAK----SLQDSLDIM 715
            .:..:    :..|.:.:|
  Rat   730 EKLVEMIFHAFHDMIHLM 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	186/658 (28%)
Crot	XP_038964380.1	Carn_acyltransf	160..743	CDD:395612	184/652 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920