DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and Cpt1c

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001344599.1	Gene:	Cpt1c / 78070	MGIID:	2446526	Length:	799	Species:	Mus musculus

Alignment Length:	761	Identity:	221/761 - (29%)
Similarity:	317/761 - (41%)	Gaps:	151/761 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAALFSKLRSFSIGSGPNSPQRVVSNLRGFLT----------------HRLSNITPSDTGW---K 62
            |..|..|::......|....|     |:|||:                |....:..|..||   .
Mouse    80 SLGLMEKIKELLPDWGGQHHQ-----LQGFLSAAVFASCLWGALIFTLHVALRLLLSHHGWLLEP 139

  Fly    63 DSILSIP-KKWLSTAESVDE-----FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKE 121
            ...:|.| |.||:.......     |.|...||:.|||:..||:..|:.::.|:......:|...
Mouse   140 HGAMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPSAQETVRKYLESVRPVLGDDAFDRATA 204

  Fly   122 LIRQF---SAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFK 183
            |...|   .||     ||..||..|.....|:...:|...:|:..|..| |||...|:   :.|.
Mouse   205 LANDFLRLHAP-----RLQLYLQLKSWCTSNYVSDWWEEFVYLRSRGSL-INSTYYMM---QDFL 260

  Fly   184 TVHDVAHFAAR---LLDGILSHREMLDSGEL-PLERAASREKNQPLCMAQYYRLLGSCRRPGVKQ 244
            .|......|||   .:..:|.:|.:|:..|: |......|    |||.|||.|:..:.|.|||::
Mouse   261 YVTPTPLQAARAGNAVHTLLLYRHLLNRQEISPTLLMGMR----PLCSAQYERMFNTTRIPGVEK 321

  Fly   245 DSQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVP- 308
            |      ..|...:.|||.|..|.:.:.|... |..|.||...:..|...:|.|..  ||.|:.
Mouse   322 D------HLRHLQDSRHVAVFHRGRFFRVGTH-SPNGLLSPRALEQQFQDILDDPS--PACPLEE 377

  Fly   309 -VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD-EPLAGNFNARGFTGATPTVHR 371
             :..|||.|||.||:.||.::......  ||.:|.|...:.|| ||       .|.|...|
Mouse   378 HLAALTAAPRSMWAQVRESVKTHAATA--LEAVEGAAFFVSLDSEP-------AGLTREDP---- 429

  Fly   372 AGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSE------------G 424
            |...|.  .||.::.|.|.:     |||||:..||:.::|..||..|||.::            .
Mouse   430 AASLDA--YAHALLAGRGHD-----RWFDKSFTLIVFSNGKLGLSVEHSWADCPVSGHLWEFTLA 487

  Fly   425 IAVVQLLEKIYKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYV 489
            ....||........:.|||..       ||.|:||:|.:..|:|...:.|.:.......::|.:|
Mouse   488 TECFQLGYATDGHCKGHPDPT-------LPQPQRLQWDLPEQIQPSISLALRGAKTLSGNIDCHV 545

  Fly   490 YRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEAL 554
            :.:..:||:|||.|.||.|.:|||.|||||::..|:...|||||.||.||.||.:.:|:.:.||.
Mouse   546 FPFSHFGKSFIKCCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREAC 610

  Fly   555 EWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDI 619
            ::.:||               |.:|         :..|...|||.||.:...::...:.|.|||.
Mouse   611 QFVRAM---------------DNKE---------TDQHCLALFRVAVDKHQALLKAAMSGQGIDR 651

  Fly   620 PLLGLREASIEVTGEMHELFKDES----YIISQCFLLSTSQVACS-------------TDSFMGY 667
            .|..|.        .|..|...:|    .:.||.:|||||||...             ..|..|:
Mouse   652 HLFALY--------IMSRLLHMQSPFLTQVQSQQWLLSTSQVPVQQTHLIDVHNYPDYVSSGGGF 708

  Fly   668 GPVTPRGYGCSYNPHPEQ-IVFCVSAFYSCEDTSASRYAKSLQDSL 712
            ||....|||.||....|. |.|.:|:..|..:|.:.|..:.::::|
Mouse   709 GPAHDHGYGISYIFMGENAITFHISSKKSSTETDSHRLGQHIENAL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	201/665 (30%)
Cpt1c	NP_001344599.1	CPT_N	1..46	CDD:318644
		Carn_acyltransf	171..754	CDD:307070	200/663 (30%)
		Coenzyme A binding. /evidence=ECO:0000250	552..564		8/11 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920