Protein Alignment ChAT and crot

DIOPT Version :10

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001018161.1
• Gene: crot / 553204
• ZFINID: ZDB-GENE-050522-35
• Length: 612
• Species: Danio rerio
• Alignment Length: 676
• Identity: 196/676 - (28%)
• Similarity: 318/676 - (47%)
• Gaps: 114/676 - (16%)

  Fly    74 STAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQ 138
            |:||..  |.:..:||.:|||||.:|::.|:.|::|..:..:...|..::::|.  :|||..|||
Zfish     8 SSAERT--FQYQRSLPPLPVPALRDTLSKYLDAVKPFASEEEFGATVAIVKRFE--EGIGQELHQ 68

  Fly   139 YLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPG-------MVFPPR---RFKTVHDVAHFAA 193
            .||.:.:::.||...:||:..|:::|||..:|.|.|       ..:||:   :.:....|.....
Zfish    69 KLLQRAKSKRNWLEEWWLDTAYLEVRIPSQLNVNFGGPTAYLEHCWPPQEGTQLERTSMVLWLTF 133

  Fly   194 RLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDS--QFLPSRERLN 256
            :..|.|.:.|       |.:.:|.:    .|..|.|:..|..:|:.||:.:|:  .|..: |...
Zfish   134 QCWDLIRTER-------LAIHKAGT----IPFDMDQFRMLFCTCKVPGITKDTILNFFKT-ESEG 186

  Fly   257 DEDRHVVVICRNQMYCVVLQASDRGK-LSESEIASQILYVLSDAPCLPAKPVPVGL--LTAEPRS 318
            ....||:|:||.:::  ...|...|: |:..|:..|:.|:.:   |...:|...|:  ||.|.|:
Zfish   187 PCPSHVIVMCRGRIF--TFDALCDGRILTPPELLRQLTYIKN---CCDGEPEGDGVSALTTEERT 246

  Fly   319 TWARDRE-MLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAH 382
            .||:.|| ::..|..|:..||.|::|..|:.||:       |:.:  |||.       :.|.:..
Zfish   247 RWAKAREYLISMDPVNKTILETIQSALFVVGLDD-------AKPY--ATPD-------NYTQLTD 295

  Fly   383 EMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHS-------CSEGIAVVQLLEK---IYKK 437
            ..:.|     :..|||.||:..|:..::|.:....:|:       .|.|..|.|.|:.   ::|.
Zfish   296 LALTG-----DPTNRWGDKSYNLVCYSNGIFSSNCDHAPYDAMVLVSNGYYVDQKLKACGGVWKG 355

  Fly   438 IEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKS 502
            :|         ....:|.||.|.:.|..:::...|.|.:...|...||....|.:.|:|||.||.
Zfish   356 LE---------VVRQMPVPEELIFTVDERVRRDIALAKEQYSKSCQDLQVVSYAFTSFGKTAIKK 411

  Fly   503 CQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGAN 567
            .::.||.::|||||||:|:.:|:....||:|:||||.|||.:.:|..:.||..|.:.|..
Zfish   412 RKLHPDTFVQLALQLAYYRQHGQPGCCYETATTRRFFHGRTETMRPCTMEAQHWCRTMMN----- 471

  Fly   568 VPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGL----REAS 628
             |..:..|.                 |.....||.:..::|.:...|.|||..||||    :|.|
Zfish   472 -PAATTEEK-----------------RHTLHAAVNKHNKLMAEAQDGKGIDRHLLGLYLIAKENS 518

  Fly   629 IEVTGEMHELFKDESYIIS---QCFLLSTSQVACSTDSFMG-YGPVTPRGYGCSYNPHPEQIVFC 689
            |.|.    ||:.|..|..|   ..|:||||.|..:|  .:| ..|:.|.|||..|....::||..
Zfish   519 IPVP----ELYADPLYTKSGGGGNFVLSTSLVGYTT--VLGAVAPMVPHGYGFFYRIRDDRIVAS 577

  Fly   690 VSAFYSCEDTSASRYAKSLQDSLDIM 715
            .:|:.|..:|.|....::|..||..|
Zfish   578 CTAWKSNPETDAETLFQNLATSLHEM 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	187/651 (29%)
crot	NP_001018161.1	Carn_acyltransf	23..596	CDD:459926	186/650 (29%)