DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and cpt1a2b

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_021329867.1	Gene:	cpt1a2b / 550361	ZFINID:	ZDB-GENE-050417-155	Length:	807	Species:	Danio rerio

Alignment Length:	775	Identity:	210/775 - (27%)
Similarity:	332/775 - (42%)	Gaps:	148/775 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 STSAAGSGPESAALFSKLRSFSIGSGPNSPQRVVSNLRGFLT-----HRLSNITPSDTGWKDSIL 66
            |.|..|....||.|||.|...|:          :..||..|.     ||...........|..:.
Zfish    96 SLSPQGQTMLSALLFSTLLWMSL----------ILTLRFCLKLLLSYHRWMFEQHGHMSTKTKVW 150

  Fly    67 SIPKKWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQG 131
            :...|.||:.:.: .:.:..:||.:|||.:.:|:..|:.:::|:......:|.:.|..:|.  :.
Zfish   151 ATLVKLLSSRKPL-LYSYQTSLPHLPVPPIKDTLERYLESVKPLLDLDGFQRMRRLTSEFE--KS 212

  Fly   132 IGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSN-PGMVF---PPRRFKTVHDVAHFA 192
            :|.||.:||..|.....|:...:|...:|:..|.|:.:||| .||.|   .|    |.:..|. |
Zfish   213 LGNRLQRYLRLKALWATNYVSDWWEEYVYLRSRSPIMVNSNYYGMDFLYVTP----TPNQAAR-A 272

  Fly   193 ARLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLND 257
            ...:..:..:|..::..||...|.....  .|||.||..|:..:.|.||.:...
Zfish   273 GNTITALFLYRRKVNREELNPSRIPGTV--IPLCAAQCERMFNTTRTPGEETGK----------- 324

  Fly   258 EDRHVVVICRN----------QMYCV--VLQ---------ASDRGK------------LSESEIA 289
              |..:..||:          |..|:  |||         ...||:            ||..||.
Zfish   325 --RTFIQTCRHKYALRKWPLMQSLCLSDVLQHWQDSEFVAVYHRGRYFRLWVYRAGRLLSPREIQ 387

  Fly   290 SQILYVLSDAPCLPAKPVP----VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD 350
            .||..:|.|    |:.|.|    :|.|||..|:.|||.|:.......|:::|:.||.|...:.||
Zfish   388 FQIQRILDD----PSPPSPGEEKLGALTAGNRTPWARVRKQFFSSGVNKQSLDCIEKAAFFVTLD 448

  Fly   351 EPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGL 415
            :      .|.|..|..|:.:.  ||    .|..::||     ...:|||||:..:::..:|..||
Zfish   449 D------QAEGMKGENPSENL--DR----YAKSLLHG-----KCYDRWFDKSFSVVVYKNGKNGL 496

  Fly   416 CYEHSCSEGIAVVQLLEKIYKKIEEHPDEDN-----GLPQHHLPPPERLEWHVGPQLQLRFAQAS 475
            ..|||.::...|..|.|........|...::     |...|.||.|:||.|.:..::|.:.:::.
Zfish   497 NAEHSWADAPIVAHLWEFTLATDTFHLGYNSDGNCRGDVDHSLPHPQRLSWDIPFEVQTQISESL 561

  Fly   476 KSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLH 540
            .......|::|.:|:.::.:||..||..::|||.::|||||||:|:..|....|||::.||.|..
Zfish   562 AVAQALADEVDCHVFPFRKFGKGLIKKMKLSPDSFVQLALQLAYYRDRGTFCLTYEASMTRLFRE 626

  Fly   541 GRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQT 605
            ||.:.:|:.|.|:..:..|:   ||.        ||.|:.||:......|.  :.|:|.|:.
Zfish   627 GRTETVRSCSNESCAFVLAL---EGG--------EDREQCRKLLRKTAEKH--QNLYRLAMT--- 675

  Fly   606 EVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQVACSTDSFM----- 665
                    |:|||..|..|...| :..|......|:   ::|:.:.|||||.........
Zfish   676 --------GSGIDRHLFCLYVVS-KYLGVESPFLKE---VLSEPWRLSTSQTPVQQMELFDLVNH 728

  Fly   666 --------GYGPVTPRGYGCSYNPHPEQIV-FCVSAFYSCEDTSASRYAKSL-QDSLDIM 715
                    |:|||...|||.||....|.:: |.||..:||::|.:.::...: |..:|:|
Zfish   729 PEFISLGGGFGPVADDGYGVSYIIMGEDMINFHVSCKHSCKETDSHKFGCQVSQAMVDLM 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	191/689 (28%)
cpt1a2b	XP_021329867.1	CPT_N	1..46	CDD:318644
		HAUS5	<75..237	CDD:317253	37/153 (24%)
		Carn_acyltransf	171..784	CDD:307070	189/683 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920