DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and cpt1b

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001315121.1	Gene:	cpt1b / 449677	ZFINID:	ZDB-GENE-041010-9	Length:	770	Species:	Danio rerio

Alignment Length:	698	Identity:	197/698 - (28%)
Similarity:	311/698 - (44%)	Gaps:	132/698 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KKWLSTAESVDE-----FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFS-- 127
            |.|||..:.:..     :.|..:||.:|||::|:|:..|:.::.|:....|.::.:.:...|.
Zfish   148 KVWLSLVKLLSGRRPLLYSFQGSLPHLPVPSIDDTIRRYLESVRPLLDDEQYKQMETVANDFKKD 212

  Fly   128 -APQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTV------ 185
             ||     :|.::|..|.....|:...:|...:|:..|.|:.:|||         |.|:
Zfish   213 PAP-----KLQKHLKLKSWWATNYVSDWWEEYIYLRGRDPIMVNSN---------FYTMDLLYVI 263

  Fly   186 --HDVAHFAARLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQF 248
              :..|..|..::..:|.:|..|:.|||...||..   ..|:|..||.|:..:.|.||::.|  |
Zfish   264 PTYRQAARAGNVVHAMLQYRRKLERGELTPLRALG---IVPMCSFQYERMFNTTRIPGIETD--F 323

  Fly   249 LPSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVPVGL-- 311
            :   :.|.|. :|:||..|.:::.|.|....| .|..||:..|...:|.|    .::|.|..|
Zfish   324 V---QHLKDR-KHLVVYHRGRLFKVWLYYGGR-HLWPSELELQFQRILDD----KSEPQPGELKL 379

  Fly   312 --LTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGD 374
              |||..|..|||.|.....:..|:.:||.||||...|.||:      .|.|:
Zfish   380 PSLTAGNRVPWARARLKYFGEGVNRASLEAIETAAFFLTLDD------EAHGY------------ 426

  Fly   375 RDETNM------AHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEK 433
             |..|:      |..::||     ...:|||||:..||:..:|..|:..|||.::...:..:.|.
Zfish   427 -DPENIRSLDLYAKSLLHG-----KCYDRWFDKSFNLIVYKNGKMGVNTEHSWADSPIIGHMWEY 485

  Fly   434 IYK--------KIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCI-DDLDFYV 489
            :..        ..|.|...|   ....|.||.||:|.: |:......:.|..:.|.| ||:||:.
Zfish   486 VLATDCFHLGYTAEGHCKGD---VNKTLAPPTRLQWDI-PKACQEIIEGSYRIAKGIADDVDFHG 546

  Fly   490 YRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEAL 554
            ..:..:||..||.|:.|||.:||||||||.|:..|....||||:.||.|..||.:.:|:.:.|:.
Zfish   547 CLFNEFGKGLIKKCRTSPDAFIQLALQLAQYRDKGEFCLTYESSMTRMFREGRTETVRSCTCEST 611

  Fly   555 EWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDI 619
            .:.:||           .|.....|.|...|...::.| :.::|.|:.           |.|||.
Zfish   612 AFVRAM-----------EDDTTTNEQRLALFKQAAEKH-QNMYRLAMT-----------GAGIDR 653

  Fly   620 PLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQV------ACSTDSFM-------GYGPVT 671
            .|..|...| :|.|......|.   ::|:.:.|||||.      ...|..|.       |:|||.
Zfish   654 HLFCLYIVS-KVMGIDSPFLKQ---VLSEPWRLSTSQTPQQQLNLIDTQKFPKYVSAGGGFGPVA 714

  Fly   672 PRGYGCSYNPHPEQIV-FCVSAFYSCEDTSASRYAKSLQDSLDIMRDL 718
            ..|||.||....|.:: |.:|:.:|..:|.:.|:.::::.::..:|.|
Zfish   715 DDGYGVSYIIVGENLITFHISSKFSSPETDSFRFGQNIRQAMQDIRAL 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	190/671 (28%)
cpt1b	NP_001315121.1	CPT_N	1..46	CDD:293093
cpt1b	NP_001315121.1	Carn_acyltransf	171..760	CDD:279140	190/671 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920