DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and CG5265

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_650605.1	Gene:	CG5265 / 42074	FlyBaseID:	FBgn0038486	Length:	643	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	205/669 - (30%)
Similarity:	326/669 - (48%)	Gaps:	99/669 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 STAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQ 138
            |||:...:...|:.| |..|..|:|.:..::..::|:.||.:.::.:::..:|...:  ||:|.:
  Fly    36 STAKDKPKSDQPNLL-KYHVLPLEEILNRFMITVQPLLTPEEFKKQEKITNEFQRKE--GAKLQK 97

  Fly   139 YLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHR 203
            .|.:..|.|.||..:.||...|:..|.|:...|:|||.||.::|::||:...:.:|::.|:....
  Fly    98 LLEETGEQEKNWLAHRWLKVAYLQFRSPVTCFSSPGMTFPKQKFESVHEFVDYTSRVIFGLGEFN 162

  Fly   204 EMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDE------DRHV 262
            :::.:.::|:.:....|    |..:|:.::.|:||.|            .|..|:      ..:|
  Fly   163 DLVHAKKIPIVKMGKNE----LDNSQFGKVFGTCRIP------------RRFTDDIVYNPCSDYV 211

  Fly   263 VVICRNQMYCVVLQASDR-GKLSESEIASQILYVLSDAPCLPAK-----------PVPVGLLTAE 315
            |||.||..|  .|:..|: |||        |:     ||||..:           .||.|:||.:
  Fly   212 VVIYRNHFY--QLKIYDKEGKL--------II-----APCLAVQLEEIMAKEKEPGVPYGILTTD 261

  Fly   316 PRSTWARDREMLQEDERNQRNLELIETAQVVLCLDE---PLAGNFNARGFTGATPTVHRAGDRDE 377
            .|..||...|.|....||:..|:.|:.|...:.|||   |..|                   ||.
  Fly   262 SRDNWAEAYEHLSNTPRNRVALKTIQNAMFTVSLDECTSPKEG-------------------RDA 307

  Fly   378 TNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYKKIEEHP 442
            ..:...:|||.||:.||.|||.|||:||::..:|..|..||||.:||..:..:::.:.||:::.|
  Fly   308 EELILTLIHGKGSKCNSANRWMDKTIQLVVNPNGHVGFTYEHSPAEGQPIAMMMDYVVKKMKDDP 372

  Fly   443 DEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSP 507
            .......::.:|..:.....|...::.....|.|:|||.:.||...|.::..|||.|||..::.|
  Fly   373 SYGECGSENFIPAKKIKFCDVSKCVEQWLIIAQKNVDKLVQDLQMKVLKFDCYGKDFIKKQRLGP 437

  Fly   508 DVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLES 572
            |.::|:|||||.:||:....|.||||..|.|..||.:.||:.|.|:|.:..||
  Fly   438 DSFVQMALQLAFFKLHYEPAAQYESAHLRIFDGGRTETIRSCSNESLAFCHAM------------ 490

  Fly   573 DREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVK-NILGNGIDIPLLGLREASIEVTGEMH 636
              :|...|.:.:.|     .:||...|     .::..| .:||.|:|..|.||:..::|....:.
  Fly   491 --DDVSASAQERAS-----KIREAVMC-----HQMYAKLALLGKGVDRHLFGLKLMAVENCLPVP 543

  Fly   637 ELFKDESYIISQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSA 701
            |.|....|:.|..|.:||||||...|:||||||....||.|.|||....|:..:||:..|:.|..
  Fly   544 EFFSSPGYVKSTHFRMSTSQVATKYDAFMGYGPSVEDGYACCYNPREHDIILAISAWRHCQATDH 608

  Fly   702 SRYAKSLQDSLDIMRDLLQ 720
            .:.||:|..|...|:|:|:
  Fly   609 QKIAKALAQSFAEMKDVLE 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	198/649 (31%)
CG5265	NP_650605.1	Carn_acyltransf	49..623	CDD:279140	198/650 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469035
Domainoid	1	1.000	234	1.000	Domainoid score	I397
eggNOG	1	0.900	-	-		E1_KOG3717
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I707
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15298at7147
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm24513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X630
	10	9.900