DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and CG5122

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_609601.1	Gene:	CG5122 / 34703	FlyBaseID:	FBgn0032471	Length:	1263	Species:	Drosophila melanogaster

Alignment Length:	658	Identity:	200/658 - (30%)
Similarity:	331/658 - (50%)	Gaps:	60/658 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IPKKWLST-----AESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFS 127
            :|||.:.:     |::.::......|.|.|...|.:::|.|:.::||.....:|:..:::.::|.
  Fly   640 VPKKCIKSEIRHLADANNDPNKKPELKKFPALPLKQSIASYLSSIEPFLNEEELKVEQKVAKKFV 704

  Fly   128 APQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFA 192
            ..:  ||:|.|.|.::.|..|||....|....|:..:.||.:.|:||:.||.:.||..:|..:|.
  Fly   705 DNE--GAKLQQLLEEEAEGTDNWLTPRWTRSAYLTYQAPLTVFSSPGLSFPIQEFKDTNDFLNFT 767

  Fly   193 ARLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLND 257
            |:.:.|:...::::|..::|:.:....:    |..:|:.::.|:.|:||     :|..:.|:.||
  Fly   768 AKAIYGMCEFKQLVDQNKIPVVQMGKHQ----LDNSQFGKIFGTVRKPG-----RFCDTIEQYND 823

  Fly   258 EDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWAR 322
            .| ::||:..|..:.:.:. |..|.|..:......|..:.:.|....|  ..||||.:.||.||.
  Fly   824 AD-YIVVVYNNNYFKLPIY-SQSGALLHAHTLRDALQDILECPIKVGK--HFGLLTHDNRSNWAE 884

  Fly   323 DREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHG 387
            ...:|.....|...:|.||.:..|:|||             ...||   ....:....||:::||
  Fly   885 AYTVLCRPHGNADTVETIEQSLFVVCLD-------------NCVPT---PKGEERIVQAHQLLHG 933

  Fly   388 GGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYKKIEEHPDEDNGLPQHH 452
            ||...||.|||.|||:|||:..:|..|.|||||.::...:..|::.:..|:.|......|.....
  Fly   934 GGVRQNSANRWMDKTIQLIVNPNGLAGFCYEHSPADCQPLAMLMDFVQLKVTEPNYGCEGCEADK 998

  Fly   453 LPPPERLEWH-VGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQ 516
            ......|::. |...:.|...||.:::.:.:..|...|..::.|||.|||:..::||.|||:||.
  Fly   999 KVTSNLLKFQPVNECINLWLCQARRNIQRIVSQLQMNVINFECYGKCFIKAQGLNPDSYIQMALS 1063

  Fly   517 LAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESR 581
            ||:|.:||::.|.||||..|.|..||.:.||:.|.|:..:..||              :.|:.|.
  Fly  1064 LAYYSMYGKIPAQYESAHLRIFHEGRTETIRSTSNESKTFLLAM--------------QSEKASM 1114

  Fly   582 KVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYII 646
            ..|.:...|         ||....:::.:.|.|.|||..|.||:|.::|....:.|.|:.:.|:.
  Fly  1115 SEKLAALQK---------AVDAHEKLIKEAINGQGIDRHLFGLQEMALEKGMPIPEFFRSKGYVR 1170

  Fly   647 SQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKSLQDS 711
            |..|.|.|||||.|.:.||.|||:...|||..|||...:|.|.:||:.||::.:..|:||:::.|
  Fly  1171 SVTFQLFTSQVATSNEGFMAYGPLLSDGYGVCYNPKESKITFAISAWKSCKEINTIRFAKAIKKS 1235

  Fly   712 LDIMRDLL 719
            |:.||.|:
  Fly  1236 LNDMRKLI 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	193/628 (31%)
CG5122	NP_609601.1	Carn_acyltransf	665..1240	CDD:279140	193/628 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469036
Domainoid	1	1.000	234	1.000	Domainoid score	I397
eggNOG	1	0.900	-	-		E1_KOG3717
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15298at7147
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm24513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X630
	9	8.850