Protein Alignment ChAT and Crat

DIOPT Version :9

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001004085.1
• Gene: Crat / 311849
• RGDID: 1303031
• Length: 626
• Species: Rattus norvegicus
• Alignment Length: 640
• Identity: 237/640 - (37%)
• Similarity: 364/640 - (56%)
• Gaps: 56/640 - (8%)

  Fly    86 DTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNW 150
            |.||::|||.|.:::..|::||:||.:..:...||:|:.:|....|:|.||.:.|..:.:..:||
  Rat    33 DALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKKMENW 97

  Fly   151 AYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGELPLER 215
            ...:||...|:..|.|:.|.|:||::.|.:.|..:.....|||:|::|:|..:.|:|:..||:|.
  Rat    98 LSEWWLKTAYLQFRQPVVIYSSPGVLLPKQDFMDLQGQLRFAAKLIEGVLDFKSMIDNETLPVEF 162

  Fly   216 AASREKNQPLCMAQYYRLLGSCRRPGVKQDS--QFLPSRERLNDEDRHVVVICRNQMYCVVLQAS 278
            ..    .|||||.|||::|.|||.||:||||  .||.|::    ...|:.|:...|.:.:.:..|
  Rat   163 LG----GQPLCMNQYYQILSSCRVPGLKQDSVVNFLKSKK----PPTHITVVHNYQFFELDVYHS 219

  Fly   279 DRGKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETA 343
            |...|:..:|..|:..:.:.:  |.:...|||:||:..|::||:....|.:|:.|:.::..|:.:
  Rat   220 DGTPLTSDQIFVQLEKIWNSS--LQSNKEPVGILTSNHRNSWAKAYSSLIKDKVNRESVNSIQKS 282

  Fly   344 QVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIIC 408
            ...:|||:.:             |.|  :.|...:::|.:|:|||||::||||||||||:|.|:.
  Rat   283 IFTVCLDKQV-------------PRV--SDDVYRSHVAGQMLHGGGSKFNSGNRWFDKTLQFIVA 332

  Fly   409 TDGTWGLCYEHSCSEGIAVVQLLEKI--YKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRF 471
            .||:.|:.|||:.:||..:|.|::.:  |.|..|....    |...||.|::|.:::.|:::...
  Rat   333 EDGSCGMVYEHAAAEGPPIVALVDHVMEYTKKPELVRS----PMVPLPMPKKLRFNITPEIKNDI 393

  Fly   472 AQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTR 536
            .:|.:::...|.|||..:..:..:||.|.||.::|||.:||:|||||:|::||:..|||||||.|
  Rat   394 EKAKQNISIMIQDLDIMMLVFHHFGKDFPKSQKLSPDAFIQIALQLAYYRIYGQACATYESASLR 458

  Fly   537 RFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAV 601
            .|..||.|.||:|||::|.:.|.|   :...||         |.::|           ||.|.||
  Rat   459 MFHLGRTDTIRSASTDSLAFVKGM---DDPKVP---------EQQRV-----------ELLRKAV 500

  Fly   602 ARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQVACSTDSFMG 666
            ........:.|.|...|..||||:..:||....|.::|.|.||.|:..|.||||||...||..|.
  Rat   501 QAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMS 565

  Fly   667 YGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKSLQDSLDIMRDLLQN 721
            :|||.|.|||..|||....|.|.|||:.||.:|:|:|.|..|:.:|..||.||||
  Rat   566 FGPVVPDGYGICYNPMEAHINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQN 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	230/631 (36%)
Crat	NP_001004085.1	Carn_acyltransf	35..615	CDD:279140	230/631 (36%)
		Coenzyme A binding. /evidence=ECO:0000250|UniProtKB:P47934	423..430		3/6 (50%)
		Microbody targeting signal. /evidence=ECO:0000255	624..626

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm45085
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920