DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and Cpt1c

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_006229128.1	Gene:	Cpt1c / 308579	RGDID:	1305384	Length:	802	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	210/719 - (29%)
Similarity:	313/719 - (43%)	Gaps:	119/719 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FLTHRLSNITPSDTGW---KDSILSIP-KKWLSTAESVDE-----FGFPDTLPKVPVPALDETMA 101
            |..|....:..|..||   ....:|.| |.||:.......     |.|...||:.|||...||:.
  Rat   120 FTLHVALRLLLSHHGWLLEPHGTMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPGAQETVR 184

  Fly   102 DYIRALEPITTPAQLERTKELIRQF---SAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDI 163
            .|:.::.|:......:....|...|   .||     ||..||..|.....|:...:|...:|:..
  Rat   185 KYLESMRPVLRDDAFDSVVALANDFLRLQAP-----RLQLYLQLKSWCASNYVSDWWEEFVYLRS 244

  Fly   164 RIPLPINSNPGMVFPPRRFKTVHDVAHFAAR---LLDGILSHREMLDSGELPLERAASREKNQPL 225
            |..| :||...|:   :.|..|......|||   .:..:|.:|.:|:..|:|.......   :||
  Rat   245 RGSL-VNSTYYMM---QDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEIPPTLLMGM---RPL 302

  Fly   226 CMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIAS 290
            |.|||.|:..:.|.|||::|  :|...:    :.:||.|..:.:.:.|...:|: |.||...:..
  Rat   303 CSAQYERMFNTTRIPGVEKD--YLCHLQ----DSQHVAVFHQGRFFRVGTHSSN-GLLSPRALEQ 360

  Fly   291 QILYVLSDAPCLPAKPVP--VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD-EP 352
            |..|:|.|..  ||.|:.  :..|||.|||.||:.||.::......  ||.:|.|...:.|| ||
  Rat   361 QFQYILDDPS--PACPLEEHLAALTAAPRSMWAQVRESVKTHAATA--LETVEGAAFFVSLDSEP 421

  Fly   353 LAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCY 417
                   .|.|...|    |...|  ..||.::.|.|.:     |||||:..||:.::|..||..
  Rat   422 -------AGLTRENP----AASLD--TYAHTLLTGQGHD-----RWFDKSFTLIVFSNGKLGLSV 468

  Fly   418 EHSCSEGIAVVQLLE--------KIYKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRFAQA 474
            |||.::......|.|        ::....:.|   ..|.|...||.|:||:|.:..|:|...:.|
  Rat   469 EHSWADCPVAGHLWEFTLATECFQLGYATDGH---CKGHPDPALPKPQRLQWDLPKQIQPSISLA 530

  Fly   475 SKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFL 539
            .:.......::|.:|:.:..:||:|||.|.||.|.:|||.|||||::..|:...|||||.||.||
  Rat   531 LRGAKTLSGNIDCHVFPFFHFGKSFIKGCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFL 595

  Fly   540 HGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQ 604
            .||.:.:|:.:.||.::.:||         ...:|.|::              ...|||.||.:.
  Rat   596 EGRTETVRSCTREACQFVRAM---------ENKERTDQQ--------------CLALFREAVDKH 637

  Fly   605 TEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDES----YIISQCFLLSTSQVACS----- 660
            ..::...:.|.|||..|..|.        .|..|...:|    .:.||.:||||||:...
  Rat   638 QALLKAAMSGQGIDRHLFALY--------IMSRLLHMQSPFLTQVQSQQWLLSTSQIPVQQTHLF 694

  Fly   661 --------TDSFMGYGPVTPRGYGCSYNPHPEQ-IVFCVSAFYSCEDTSASRYAKSLQDSLDIMR 716
                    ..|..|:||....|||.||....|. |.|.:|:..|..:|.:.|..:.::|:|..:.
  Rat   695 DVHNYPDYVSSGGGFGPAHDHGYGVSYIFMGENAISFHISSKQSSTETDSHRLGQHIEDALLDVA 759

  Fly   717 DLLQ 720
            .|.|
  Rat   760 SLFQ 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	196/662 (30%)
Cpt1c	XP_006229128.1	CPT_N	1..46	CDD:293093
Cpt1c	XP_006229128.1	Carn_acyltransf	171..758	CDD:279140	196/661 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920