DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and Cpt1a

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_113747.2	Gene:	Cpt1a / 25757	RGDID:	2396	Length:	773	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	198/722 - (27%)
Similarity:	319/722 - (44%)	Gaps:	130/722 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RVVSNLRGFLTHRLSNITPSDTGWKD--SILSIPKKWLSTAESVDEFGFPDTLPKVPVPALDETM 100
            :|:.:..|::......::.|...|..  .:||..|..|        :.|..:||::||||:.:|:
  Rat   127 KVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPML--------YSFQTSLPRLPVPAVKDTV 183

  Fly   101 ADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRI 165
            :.|:.::.|:......:|...|.:.|:.  .:|.:|..||..|.....|:...:|...:|:..|.
  Rat   184 SRYLESVRPLMKEEDFQRMTALAQDFAV--NLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRG 246

  Fly   166 PLPINSN----------PGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGEL-PLERAASR 219
            ||.:|||          |..:...|...|:|           .||.:|..||..|| |:....|
  Rat   247 PLMVNSNYYAMEMLYITPTHIQAARAGNTIH-----------AILLYRRTLDREELKPIRLLGS- 299

  Fly   220 EKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLS 284
              ..|||.||:.||..:.|.||.:.|     :.:.:.| .||:||..|.:.:.|.|....| .|.
  Rat   300 --TIPLCSAQWERLFNTSRIPGEETD-----TIQHIKD-SRHIVVYHRGRYFKVWLYHDGR-LLR 355

  Fly   285 ESEIASQILYVLSDAPCLPAKPVP----VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQV 345
            ..|:..|:..:|.|    |::|.|    :..|||..|..||:.|:......:|:::|:.:|.|..
  Rat   356 PRELEQQMQQILDD----PSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAF 416

  Fly   346 VLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTD 410
            .:.|||      :.:|:....|      :....:.|..::||     ...:|||||::..::..:
  Rat   417 FVTLDE------SEQGYREEDP------EASIDSYAKSLLHG-----RCFDRWFDKSITFVVFKN 464

  Fly   411 GTWGLCYEHSCSEGIAVVQLLEKIYKK--IEEHPDED---NGLPQHHLPPPERLEWHVGPQLQLR 470
            ...|:..|||.::...|..|.|.:...  .:....||   .|....::|.|.||:|.:..:.|..
  Rat   465 SKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEV 529

  Fly   471 FAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESAST 535
            ...:..|.....:|:|.:.:.:.|:||..||.|:.|||.:|||||||||||..|:...|||::.|
  Rat   530 IDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMT 594

  Fly   536 RRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCA 600
            |.|..||.:.:|:.:.|:..:.:||           .|.:...|.|...|.|..:.| :.|:|.|
  Rat   595 RLFREGRTETVRSCTMESCNFVQAM-----------MDPKSTAEQRLKLFKIACEKH-QHLYRLA 647

  Fly   601 VARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESY---IISQCFLLSTSQ------ 656
            :.           |.|||..|..|...|       ..|..|..:   ::|:.:.|||||
  Rat   648 MT-----------GAGIDRHLFCLYVVS-------KYLAVDSPFLKEVLSEPWRLSTSQTPQQQV 694

  Fly   657 -----------VACSTDSFMGYGPVTPRGYGCSYNPHPEQIV-FCVSAFYSCEDTSASRYAKSL- 708
                       |:|..    |:|||...|||.||....|..: |.:|:.:|..:|.:.|:.|.|
  Rat   695 ELFDFEKNPDYVSCGG----GFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLR 755

  Fly   709 QDSLDIM 715
            |..:||:
  Rat   756 QAMMDII 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	189/670 (28%)
Cpt1a	NP_113747.2	CPT_N	1..47	CDD:406797
		Carn_acyltransf	171..761	CDD:395612	187/667 (28%)
		Coenzyme A binding. /evidence=ECO:0000250	555..567		6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920