Protein Alignment ChAT and Cpt1b

DIOPT Version :10

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_006242242.1
• Gene: Cpt1b / 25756
• RGDID: 2397
• Length: 775
• Species: Rattus norvegicus
• Alignment Length: 706
• Identity: 193/706 - (27%)
• Similarity: 308/706 - (43%)
• Gaps: 121/706 - (17%)

  Fly    57 SDTGWKDSILSIPKKWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKE 121
            |.|.....|.:|..:.||:...: .:.|..:|||:|||::..|:..|:.::.|:.......|.:.
  Rat   143 SKTSHATKIWAICVRLLSSRRPM-LYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYFRMES 206

  Fly   122 LIRQFSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVH 186
            |.::|.  ..|..||.:||:.|.....|:...:|...:|:..|.|:.:|||    :....|..:.
  Rat   207 LAKEFQ--DKIAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSN----YYAMDFVLIK 265

  Fly   187 DVAHFAARL---LDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQD-SQ 247
            :.:..||||   :..::.:|..||..|:....|...   .|:|..|..|:..:.|.||.:.| .|
  Rat   266 NTSQQAARLGNTVHAMIMYRRKLDREEIKPVMALGM---VPMCSYQMERMFNTTRIPGKETDLLQ 327

  Fly   248 FLPSRERLNDEDRHVVVICRNQMYCVVLQASDRGK--LSESEIASQILYVLSDAPCLPAKP--VP 308
            .|       .|.|||.|..:.:.:.|.|.   .|.  |...::..|...:|.|..  |.:|  ..
  Rat   328 HL-------SESRHVAVYHKGRFFKVWLY---EGSCLLKPRDLEMQFQRILDDTS--PPQPGEEK 380

  Fly   309 VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAG 373
            :..|||..|..||..|:......:|:.:|:.||.|...:.|||                ..|...
  Rat   381 LAALTAGGRVEWAEARQKFFSSGKNKMSLDTIERAAFFVALDE----------------DSHCYN 429

  Fly   374 DRDETNMA---HEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIY 435
            ..||.:::   ..::||     |..||||||:..||.|.:|..||..|||.::...:..|.|.:.
  Rat   430 PDDEASLSLYGKSLLHG-----NCYNRWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVL 489

  Fly   436 KKIEEHPDEDN-----GLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSY 495
            .....|.....     |.|...||||:|::|.:..|.|.....:.:......||::.|.:::..:
  Rat   490 ATDTFHLGYTETGHCVGEPNTKLPPPQRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPF 554

  Fly   496 GKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAM 560
            ||..||.|:.|||.::|:||||||::..|:...|||::.||.|..||.:.:|:.::|:..:.:||
  Rat   555 GKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAM 619

  Fly   561 CQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPL---- 621
            ..|.                       :.|..|::|||.|..:...:....:.|.|||..|
  Rat   620 MTGS-----------------------HKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLY 661

  Fly   622 -----LGLREASIEVTGEMHELFKDESYIISQCFLLSTSQV----ACSTDSFM---------GYG 668
                 ||:|..           |.||  ::|:.:.|||||:    .|..|...         |:|
  Rat   662 IVSKYLGVRSP-----------FLDE--VLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFG 713

  Fly   669 PVTPRGYGCSYNPHPEQIVFC-VSAFYSCEDT---SASRYAKSLQDSLDIMRDLLQ 720
            ||...|||.||....|..:|. ||:..|..:|   :|.|:...::.:|..:.||.:
  Rat   714 PVADHGYGVSYMIAGENTMFFHVSSKLSSSETFPQNALRFGNHIRQALLDIADLFK 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	180/659 (27%)
Cpt1b	XP_006242242.1	CPT_N	1..47	CDD:465132
		Carn_acyltransf	176..759	CDD:459926	180/660 (27%)