Protein Alignment ChAT and cha-1

DIOPT Version :9

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001023603.1
• Gene: cha-1 / 24105307
• WormBaseID: WBGene00000481
• Length: 627
• Species: Caenorhabditis elegans
• Alignment Length: 702
• Identity: 231/702 - (32%)
• Similarity: 354/702 - (50%)
• Gaps: 119/702 - (16%)

  Fly    62 KDSILSIP--KKWLSTAESVDEFGFPDTLPKVPVPALDETMADYIR--ALEPITTPAQLERTKEL 122
            |:.:..:|  ..|..||           |||.|||:|:.|:..|:.  |:..:...|.|..|.:.
 Worm     3 KEKVDELPPNDNWYETA-----------LPKPPVPSLEATLDRYLEYAAVVAVGQKASLATTHDA 56

  Fly   123 IRQF---SAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKT 184
            ..:|   :.|      |.:.||:..|...|||..:||.||||.:|:|.|:|||||.:||..:|:|
 Worm    57 AHKFVRQATP------LQEQLLEIAEKSPNWATKFWLPEMYMRVRMPTPVNSNPGYIFPKVKFET 115

  Fly   185 VHDVAHFAARLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFL 249
            ..|...:.|.|..|:|.::.::|:.::..|::...:|.| :||.||.|:|...|.|||.:|:|.
 Worm   116 KEDHIKYTALLTRGLLEYKNLIDTKQVCREKSTGAQKLQ-MCMEQYDRVLSCYREPGVGEDTQI- 178

  Fly   250 PSRERLNDEDRHVVVICRNQMYCVVLQASDRGKL-SESEIASQILYVLSDAPCLPAKPVPVGLLT 313
             .:::.||.:.||:|:||||.:  :|.:...|.| |.:::..|:..:...:.........:|...
 Worm   179 -RKQKTNDGNEHVLVMCRNQTF--LLHSRINGALVSYADVEYQLAQIEEISKINQNNTANIGASG 240

  Fly   314 AEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLD--EPL-------------AGNFNARGFT 363
            ..||...|...:.:...|:|.::.|.:::|..|:|||  :|:             ...|.|||::
 Worm   241 VGPRDNAALFWQDMLTVEQNSKSYEWVKSALFVVCLDMEDPIDYGKNDTMSISEKEKEFVARGYS 305

  Fly   364 GATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVV 428
            ..|                    |.||.....|||:|.|:||::.:.|..|||.|||.:|||.::
 Worm   306 TLT--------------------GHGSSKFGLNRWYDATIQLVVSSSGVNGLCIEHSTAEGIVII 350

  Fly   429 QLLEKIYKKIEEHPDED---NGLPQHHLPPPERLEWHVGPQLQLRFAQASKSV--------DKCI 482
            .:.|...:..:::....   |.:...|   |:.|.||        |::.|:::        |:..
 Worm   351 NMAETAIRYAQKYFKSKMVWNDVRNVH---PKSLTWH--------FSENSRNILKKQAEVFDELA 404

  Fly   483 DDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIR 547
            ::|:..|..:..:||..||:.:||||.:|||.:||||||.:|.||:||||||.|||..||||.||
 Worm   405 NELELEVLIFNEFGKDSIKNWRVSPDGFIQLIMQLAHYKTHGHLVSTYESASVRRFGAGRVDNIR 469

  Fly   548 AASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNI 612
            |.:.|||||..||.          |.:|.:|  ||:           |||:.||.:|.:|.::||
 Worm   470 ANTQEALEWVTAMA----------SKKESKE--RKL-----------ELFKKAVLKQVKVTLENI 511

  Fly   613 LGNGIDIPLLGL----REASIEVTGE-MHELFKDESYIISQCFLLSTSQVACS---TDSFMGYGP 669
            .|.|:|..|..|    ||.. |.||| :..||.|..:.....|.||||||..|   .|.::.||.
 Worm   512 SGYGVDNHLCALFCLARERE-ETTGEDIPSLFLDPLWSEVMRFPLSTSQVTTSLDIPDCYLTYGA 575

  Fly   670 VTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKSLQDSLDIMRDLLQN 721
            |...||||.||..|::::|..:||.|...|....:.|||..::..:::||.|
 Worm   576 VVRDGYGCPYNIQPDRVIFAPTAFRSDPRTDLQHFKKSLAGAMRDVKELLSN 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	223/667 (33%)
cha-1	NP_001023603.1	Carn_acyltransf	20..622	CDD:279140	223/667 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166546
Domainoid	1	1.000	319	1.000	Domainoid score	I674
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I1468
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45782
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		oto19054
orthoMCL	1	0.900	-	-		OOG6_107067
Panther	1	1.100	-	-	LDO	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2058
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.940