DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and cpt-6

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_504648.1	Gene:	cpt-6 / 179035	WormBaseID:	WBGene00020911	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	768	Identity:	195/768 - (25%)
Similarity:	321/768 - (41%)	Gaps:	160/768 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GPESAALFSKLRSFSIGS--GPNSPQRVVSNL----RGFLTHRLSNITPSDTGWKDSILSIPKKW 72
            |.|.|.:.......:|||  |..:.::::.:.    :|||..     .|.....|..|..|.:..
Worm    74 GSEVAEIAKTTAVAAIGSYAGVFTLRKLLKHFYFSYKGFLFD-----NPKKPCLKTKIWGIVRHI 133

  Fly    73 LSTA----ESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIG 133
            ||.:    ||.|..     ||.:|||||.:|:::|:.:::.|.:..:.|...:...:|.  :..|
Worm   134 LSISPPILESCDRL-----LPSLPVPALKDTISEYLDSMKHILSEQEYEIVAKQAHEFL--ENEG 191

  Fly   134 ARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVH-DV--------A 189
            .:|.:|........||:...:|....|:..|.||.|||:           ..| |:        |
Worm   192 KKLQRYTWIYSLFTDNYVTSFWQKYAYLHGRYPLMINSS-----------VAHCDLLRDKEATRA 245

  Fly   190 HFAARLL-DGILSHREMLDSGELPLERAASREKNQPL-CMAQYYRLLGSCRRPGVKQDSQFLPSR 252
            |.|||:. ..::||        |.::|...:.....| |...|..:....|.||.|.|...
Worm   246 HRAARVTWIEVMSH--------LAIDRQQYKALGDGLVCTRHYKNMYAVTREPGKKIDQLI---- 298

  Fly   253 ERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILY-VLSDAPCLPAKPVPVGLLTAEP 316
              |:...:|:||:.|.:.|.:.: ..|:..:...|..::|.: ::|...........:..||.:.
Worm   299 --LHGIQKHIVVVLRGKYYKIHV-VDDKNNIYTVEQLTKIFHEMISRDEKEEGVIGKIAALTHDT 360

  Fly   317 RSTWARDRE-MLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNM 380
            |.:|.|:|: ....:.:|.:.|:.||.|.....|||.     :..|:....|.|       .:|.
Worm   361 RDSWHRNRQKYFLGNVKNAQILKEIECAVFFFTLDEN-----DDYGYDEKKPEV-------LSNF 413

  Fly   381 AHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKI---------YK 436
            ....:.|.|:     |||.||::..|...:...|...|||.::|.....::|..         ||
Worm   414 LANCLSGDGT-----NRWVDKSLNYICSKNARCGGTTEHSIADGAEFDHIMENFVYVDLEVLKYK 473

  Fly   437 KIEEHPD----EDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCID-------DLDFYVY 490
            .|||...    |:|......|..|  |.:.|..|..|      ..:.:|.|       |||.|..
Worm   474 SIEEQEKMAVIEENDKKSLKLATP--LNFEVPDQEML------SEITRCYDAHQIAKNDLDLYAL 530

  Fly   491 RYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALE 555
            .::.:||..||.|.||||.:||:|:|||:|:..|:.|.|||.||.|.|.:.|.:.:|..:..:.|
Worm   531 AFRDFGKGRIKKCGVSPDAFIQMAIQLANYRDQGKFVLTYEPASARFFANSRTETLRTVNDHSCE 595

  Fly   556 WAKAMCQGEGANVPLESDREDEEESRKVKFSIYSK---DHLRELFRCAVARQTE--VMVKNIL-- 613
            :.:||.   .||           |:::.|.::..|   .|:....:|.|.:..:  :.|..||
Worm   596 FVEAML---NAN-----------ETKEAKIALLKKACETHVLRNKKCMVGQGVDRHLFVLYILSQ 646

  Fly   614 GNGIDIPLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQV-----ACSTD-----SFMG-- 666
            |.||..|.|                   ::| |:|.:.||||.|     .|..|     :::|
Worm   647 GTGIQSPFL-------------------DNY-INQKWKLSTSHVPNVTNQCDEDTDSDNTWLGAC 691

  Fly   667 YGPVTPRGYGCSYNPHPEQIVFC-VSAFYSCEDTSASRYAKSLQDSLDIMRDL 718
            :|.|...|||..|.......:|. :::::|..:|.::::||.|.:|...:.:|
Worm   692 FGAVAADGYGICYRFGGNHGIFANITSYHSAANTDSTKFAKLLSESFHELSNL 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	175/680 (26%)
cpt-6	NP_504648.1	Carn_acyltransf	148..741	CDD:376382	175/679 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920