Protein Alignment ChAT and cpt-1

DIOPT Version :10

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_496721.2
• Gene: cpt-1 / 174912
• WormBaseID: WBGene00012907
• Length: 779
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 188/718 - (26%)
• Similarity: 316/718 - (44%)
• Gaps: 138/718 - (19%)

  Fly    60 GWK-----DSILSIPKKWLSTAESVDEFG-----FPDTLPKVPVPALDETMADYIRALEPITTPA 114
            ||.     ..:....|.||.....:.:.|     |...||::|:|.||:|:..::.:::||.:..
 Worm   134 GWMYESPGKPVSKATKLWLGVLHIISKAGPMLHSFQGALPRLPLPNLDDTVRKHLLSMKPILSDE 198

  Fly   115 QLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPP 179
            :.:..:.|..:|.  :|:|.||.:||..|.....|:...:|...:||..|.|:.||||      .
 Worm   199 EFQELEFLSERFR--KGVGRRLQRYLTLKSWFSSNYVTDWWEEFVYMRQRSPIMINSN------Y 255

  Fly   180 RRFKTVHD-----VAHFAARLLDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRR 239
            ..|.|:::     .|..||.|....|..|.|:|..|:.....:.|.| .|.|..||.||..:||.
 Worm   256 YGFDTLNEHPTQNQASRAANLTYTSLQFRRMVDRQEVSPFSISPRTK-VPFCTMQYERLFNTCRV 319

  Fly   240 PGVKQDSQFLPSRERLN--DEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCL 302
            ||.:.|        ||.  |:.:|:.|.||...:.:::....| .|...|:..|...:|:.....
 Worm   320 PGEEVD--------RLLHWDDAKHIAVYCRGVWFKLIVHNGKR-LLEACELQVQYDAILAHTHEP 375

  Fly   303 PAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATP 367
            ....:.:..|||..|:.||:.|........|:.:|..||.|..|:.||:
 Worm   376 SEGEMHLASLTAGERADWAKTRRAHFRSGVNKTSLNDIERAAFVVILDD---------------- 424

  Fly   368 TVHRAGDRDET-----------NMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSC 421
                    :||           :.||.::||     .:.:|||||:..|||..:|..|:..|||.
 Worm   425 --------EETHYDPQDPSKLDHWAHNLLHG-----KAHDRWFDKSFNLIISKNGHVGINTEHSW 476

  Fly   422 SEGIAVVQLLE-KIYKKIEEHPDEDNGL----PQHHLPPPERLEWHV-GPQL-QLRFAQASKSVD 479
            .:...:....| .:.:.|.....::||.    |:..| .||||:|.: .|.| |:|  ::.:..:
 Worm   477 GDAAVMAHFTEWSLLQDIVFIGYDENGRCKGEPKEKL-TPERLKWEIPAPALDQIR--KSMEVAN 538

  Fly   480 KCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVD 544
            ..|.|::..:..:..|||.|.|..:||||.::|:.||..::|...:...|||::.||.|..||.:
 Worm   539 ALIADVEMSLLVWTDYGKGFAKKLKVSPDAFLQMTLQYTYFKNQNKFSLTYEASMTRLFREGRTE 603

  Fly   545 CIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMV 609
            .:|:.:.::.::.::|         |::.:..::..:.::.:.   |..:||:|.|:.
 Worm   604 TVRSCTVQSSDFVRSM---------LDASKTPQDRLQLLRKAC---DKHQELYRDAMC------- 649

  Fly   610 KNILGNGIDIPLLGLREASIEVTGEMHELFKDES----YIISQCFLLSTSQV---ACSTD----- 662
                |.|:|..|..|.        .:....::||    .|....:||||||.   .|..|
 Worm   650 ----GQGVDRHLFALY--------VIKRYLEEESPFFDNIFPPTYLLSTSQTPMNQCEADAKGLS 702

  Fly   663 ---------SFMGYGPVTPRGYGCSYNPHPEQ-IVFCVSAFYSCEDTSASRYAKSLQDSLDIMRD 717
                     :..|:|||..||||.||....|. :.|.:|:..|.::||:..:.:.|:.||:.|:.
 Worm   703 NEVRLRLITAGGGFGPVADRGYGVSYIVAGEDTLSFHISSKRSADNTSSREFREELKRSLNDMKK 767

  Fly   718 LLQ 720
            |.:
 Worm   768 LAE 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	175/664 (26%)
cpt-1	NP_496721.2	CPT_N	1..47	CDD:465132
		Carn_acyltransf	175..760	CDD:459926	175/665 (26%)