Protein Alignment ChAT and CPT1A

DIOPT Version :10

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001867.2
• Gene: CPT1A / 1374
• HGNCID: 2328
• Length: 773
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 190/667 - (28%)
• Similarity: 313/667 - (46%)
• Gaps: 102/667 - (15%)

  Fly    82 FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREA 146
            :.|..:||::||||:.:|:..|::::.|:......:|...|.:.|:.  |:|.||..||..|...
Human   165 YSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAV--GLGPRLQWYLKLKSWW 227

  Fly   147 EDNWAYYYWLNEMYMDIRIPLPINSNPG-----MVFPPRRFKTVHDVAHFAARLLDGILSHREML 206
            ..|:...:|...:|:..|.||.:|||..     .:.|      .|..|..|...:..||.:|..|
Human   228 ATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILP------THIQAARAGNAIHAILLYRRKL 286

  Fly   207 DSGEL-PLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQM 270
            |..|: |:....|   ..|||.||:.|:..:.|.||.:.|     :.:.:.| .:|:||..|.:.
Human   287 DREEIKPIRLLGS---TIPLCSAQWERMFNTSRIPGEETD-----TIQHMRD-SKHIVVYHRGRY 342

  Fly   271 YCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVP----VGLLTAEPRSTWARDREMLQEDE 331
            :.|.|....| .|...|:..|:..:|.:.    ::|.|    :..|||..|..|||.|:......
Human   343 FKVWLYHDGR-LLKPREMEQQMQRILDNT----SEPQPGEARLAALTAGDRVPWARCRQAYFGRG 402

  Fly   332 RNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNM---AHEMIHGGGSEYN 393
            :|:::|:.:|.|...:.|||...|              :|:.|.| |:|   |..::||     .
Human   403 KNKQSLDAVEKAAFFVTLDETEEG--------------YRSEDPD-TSMDSYAKSLLHG-----R 447

  Fly   394 SGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYK--KIEEHPDED---NGLPQHHL 453
            ..:|||||:...::..:|..||..|||.::...|..|.|.:..  .::....||   .|....::
Human   448 CYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNI 512

  Fly   454 PPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLA 518
            |.|.||:|.:..:.|.....:..:.:...:|:||:.:.:.::||..||.|:.|||.::|||||||
Human   513 PYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLA 577

  Fly   519 HYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKV 583
            |||..|:...|||::.||.|..||.:.:|:.:||:.::.:||.           |.....|.|..
Human   578 HYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMV-----------DPAQTVEQRLK 631

  Fly   584 KFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQ 648
            .|.:.|:.| :.::|.|:.           |:|||..|..|...|..:..|...|    ..::|:
Human   632 LFKLASEKH-QHMYRLAMT-----------GSGIDRHLFCLYVVSKYLAVESPFL----KEVLSE 680

  Fly   649 CFLLSTSQVACS-------------TDSFMGYGPVTPRGYGCSYNPHPEQIV-FCVSAFYSCEDT 699
            .:.|||||....             ..|..|:|||...|||.||....|.:: |.:|:.:||.:|
Human   681 PWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPET 745

  Fly   700 SASRYAKSLQDSL-DIM 715
            .:.|:.:.|:::: ||:
Human   746 DSHRFGRHLKEAMTDII 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	185/649 (29%)
CPT1A	NP_001867.2	CPT_N	1..47	CDD:465132
		Carn_acyltransf	174..756	CDD:459926	185/650 (28%)