Protein Alignment ChAT and Crat

DIOPT Version :9

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_006497708.1
• Gene: Crat / 12908
• MGIID: 109501
• Length: 631
• Species: Mus musculus
• Alignment Length: 645
• Identity: 239/645 - (37%)
• Similarity: 362/645 - (56%)
• Gaps: 61/645 - (9%)

  Fly    86 DTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNW 150
            |.||::|||.|.:::..|::||:||.:..:...||:|:.:|....|:|.||.:.|..:.:..:||
Mouse    33 DALPRLPVPPLQQSLDYYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKKMENW 97

  Fly   151 AYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHREMLDSGELPLER 215
            ...:||...|:..|.|:.|.|:||::.|.:.|..:.....|||:|::|:|..:.|:|:..||:|.
Mouse    98 LSEWWLKTAYLQFRQPVVIYSSPGVILPKQDFVDLQGQLRFAAKLIEGVLDFKSMIDNETLPVEF 162

  Fly   216 AASREKNQPLCMAQYYRLLGSCRRPGVKQDS--QFLPSRERLNDEDRHVVVICRNQMYCVVLQAS 278
            ..    .|||||.|||::|.|||.||.||||  .||.|:.    ...|:.|:...|.:.:.:..|
Mouse   163 LG----GQPLCMNQYYQILSSCRVPGPKQDSVVNFLKSKR----PPTHITVVHNYQFFELDVYHS 219

  Fly   279 DRGKLSESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETA 343
            |...|:..:|..|:..:.:.:  |.:...|||:||:..|:|||:....|.:|:.|:.::..|:.:
Mouse   220 DGTPLTSDQIFVQLEKIWNSS--LQSNKEPVGILTSNHRNTWAKAYNNLIKDKVNRESVNSIQKS 282

  Fly   344 QVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIIC 408
            ...:|||:.:             |.|  :.|....::|.:|:|||||::||||||||||:|.|:.
Mouse   283 IFTVCLDKQV-------------PRV--SDDVYRNHVAGQMLHGGGSKFNSGNRWFDKTLQFIVA 332

  Fly   409 TDGTWGLCYEHSCSEGIAVVQLLEKI--YKKIEEHPDEDNGLPQHHLPPPERLEWHVGPQLQLRF 471
            .||:.|:.|||:.:||..:|.|::.:  |.|..|....    |...||.|::|.:::.|:::...
Mouse   333 EDGSCGMVYEHAAAEGPPIVALVDHVMEYTKKPELVRS----PMVPLPMPKKLRFNITPEIKNDI 393

  Fly   472 AQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTR 536
            .:|.:::...|.|||..:..:..:||.|.||.::|||.:||:|||||:|::||:..|||||||.|
Mouse   394 EKAKQNLSIMIQDLDIMMLTFHHFGKDFPKSEKLSPDAFIQVALQLAYYRIYGQACATYESASLR 458

  Fly   537 RFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAV 601
            .|..||.|.||:||.::|.:.|.|  |: :.||         |.:||           ||.|.||
Mouse   459 MFHLGRTDTIRSASIDSLAFVKGM--GD-STVP---------EQQKV-----------ELLRKAV 500

  Fly   602 ARQTEVM-----VKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQVACST 661
            .......     .:.|.|...|..||||:..:||....|.::|.|.||.|:..|.||||||...|
Mouse   501 QAHRAYTDRISHPQAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKT 565

  Fly   662 DSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKSLQDSLDIMRDLLQN 721
            |..|.:|||.|.|||..|||....|.|.|||:.||.:|:|:|.|..|:.:|..||.||||
Mouse   566 DCVMFFGPVVPDGYGICYNPMEAHINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQN 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	232/636 (36%)
Crat	XP_006497708.1	Carn_acyltransf	35..620	CDD:376382	232/636 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3717
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm43021
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2058
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840