Protein Alignment ChAT and Cpt2

DIOPT Version :10

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_034079.2
• Gene: Cpt2 / 12896
• MGIID: 109176
• Length: 658
• Species: Mus musculus
• Alignment Length: 704
• Identity: 190/704 - (26%)
• Similarity: 311/704 - (44%)
• Gaps: 116/704 - (16%)

  Fly    65 ILSIPKKWLSTAESVDEF---------GFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTK 120
            :|..|.:.||......|:         .:.|:||::|:|.|::||..|:.|.:|:...:|..:|:
Mouse    17 VLGAPSRPLSAVSGPAEYLQHSIVPTMHYQDSLPRLPIPKLEDTMKRYLSAQKPLLNDSQFRKTE 81

  Fly   121 ELIRQFSAPQGIGARLHQYLL--DKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFK 183
            .|.:.|.  .|||..||.:||  ||:....::....|. :||:..|..:.:|.||.|.|.|....
Mouse    82 VLCKDFE--NGIGKELHAHLLAQDKQNKHTSYISGPWF-DMYLTARDSVVLNFNPFMAFNPDPKS 143

  Fly   184 TVHDVAHFAARLLDGILSHREMLDSGELPLE---------------------------RAASREK 221
            ..:|....|..|....:...:.|.:|.|..|                           ..|....
Mouse   144 EYNDQLTRATNLTVSAVRFLKTLRAGLLEPEVFHLNPARSDTDAFKRLIRFVPSSLSWYGAYLVN 208

  Fly   222 NQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERL--NDEDRHVVVICRNQMYCVVLQASDRGKLS 284
            ..||.|:||:||..|.|.|        .|||:.|  :.:.||::|:.:...|...:...|...::
Mouse   209 AYPLDMSQYFRLFNSTRIP--------KPSRDELFTDTKARHLLVLRKGHFYVFDVLDQDGNIVN 265

  Fly   285 ESEIASQILYVLSDAPCLPAKPVPVGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCL 349
            .|||.:.:.|:|||:.  |....|:..||:|.|..||..|:.|... .|:..|..:::|...|||
Mouse   266 PSEIQAHLKYILSDSS--PVPEFPLAYLTSENRDVWAELRQKLIHG-GNEETLRKVDSAVFCLCL 327

  Fly   350 DE-PLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTW 413
            |: |:                     :|..:::|.|:||.|:     ||||||:..||:..|||.
Mouse   328 DDFPM---------------------KDLVHLSHTMLHGDGT-----NRWFDKSFNLIVAKDGTA 366

  Fly   414 GLCYEHSCSEGIAVVQLLEKIYKKIEEHPDEDNGLPQHHLPPP-------ERLEWHVGPQLQLRF 471
            .:.:||:..:|:||::...::::...:.|    .:.....|..       ::|.:.:...|:...
Mouse   367 AVHFEHAWGDGVAVLRFFNEVFRDSTQTP----AIAPQSQPAATDSSVSVQKLSFKLSSALKAGV 427

  Fly   472 AQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTR 536
            ..|.:..|..:..|.....::|..||.|:|..::|||...|||.|:|..:.||:.||||||.||.
Mouse   428 TAAKEKFDATMKTLTIDAIQFQRGGKEFLKKKKLSPDAVAQLAFQMAFLRQYGQTVATYESCSTA 492

  Fly   537 RFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAV 601
            .|.|||.:.||.||......::|..:               |.|   |.|:....|:  :..|:
Mouse   493 AFKHGRTETIRPASIFTKRCSEAFVR---------------EPS---KHSVGELQHM--MAECS- 536

  Fly   602 ARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQCFLLSTSQVACSTDSFMG 666
            ....::..:..:|.|.|..|..||..:......:.||::|.:|......:||||.::....|..|
Mouse   537 KYHGQLTKEAAMGQGFDRHLFALRYLAAARGVTLPELYQDPAYQRINHNILSTSTLSSPAVSLGG 601

  Fly   667 YGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSASRYAKSLQDSLDIMRDLLQ 720
            :.||.|.|:|.:|..|.:.|...||::   ...:|..:...:|..|:.|.|.|:
Mouse   602 FAPVVPDGFGIAYAVHDDWIGCNVSSY---SGRNAREFLHCVQKCLEDMFDALE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	177/656 (27%)
Cpt2	NP_034079.2	Carn_acyltransf	52..642	CDD:459926	177/657 (27%)