DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and Cpt1b

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_034078.2	Gene:	Cpt1b / 12895	MGIID:	1098297	Length:	772	Species:	Mus musculus

Alignment Length:	689	Identity:	192/689 - (27%)
Similarity:	305/689 - (44%)	Gaps:	106/689 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SDTGWKDSILSIPKKWLSTAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKE 121
            |.|.....|.:|..:.||:...: .:.|..:|||:|||::..|:..|:.::.|:.......|.:.
Mouse   143 SKTSHATKIWAICVRLLSSRRPM-LYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYYRMET 206

  Fly   122 LIRQF---SAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFK 183
            |.::|   :||     ||.:||:.|.....|:...:|...:|:..|.||.:|||    :....|.
Mouse   207 LAKEFQDKTAP-----RLQKYLVLKSWWATNYVSDWWEEYVYLRSRSPLMVNSN----YYAMDFV 262

  Fly   184 TVHDVAHFAARL---LDGILSHREMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQD 245
            .:.:....||||   :..::.:|..||..|:....|...   .|:|..|..|:..:.|.||.:.|
Mouse   263 LIKNTNVQAARLGNAVHAMIMYRRKLDREEIKPVMALGM---VPMCSYQMERMFNTTRIPGKETD 324

  Fly   246 -SQFLPSRERLNDEDRHVVVICRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVP- 308
             .|.|       .|.|||.|..:.:.:.|.|....| .|...::..|...:|.|    |:.|.|
Mouse   325 LLQHL-------SESRHVAVYHKGRFFKVWLYEGSR-LLKPRDLEMQFQRILDD----PSPPQPG 377

  Fly   309 ---VGLLTAEPRSTWARDREMLQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVH 370
               :..|||..|..||..|:......:|:.:|:.||.|...:.|||                ..|
Mouse   378 EEKLAALTAGGRVEWAEARQTFFSSGKNKMSLDAIERAAFFVTLDE----------------DSH 426

  Fly   371 RAGDRDETNMA---HEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLE 432
            .....|||:::   ..::||     |..||||||:..||.|.:|..||..|||.::...:..|.|
Mouse   427 CYNPDDETSLSLYGKALLHG-----NCYNRWFDKSFTLISCKNGLLGLNTEHSWADAPIIGHLWE 486

  Fly   433 KIYKKIEEHPDEDN-----GLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRY 492
            .:......|.....     |.|...||||:||.|.:..|.:.....:.:......||::.|.:::
Mouse   487 FVLGTDTFHLGYTETGHCVGEPNTTLPPPQRLPWDIPEQCREAIENSYQVAKALADDVELYCFQF 551

  Fly   493 QSYGKTFIKSCQVSPDVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWA 557
            ..:||..||.|:.|||.::|:||||||::..|:...|||::.||.|..||.:.:|:.:.|:..:.
Mouse   552 LPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTNESAAFV 616

  Fly   558 KAMCQGEGANVPLESDREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLL 622
            :||.:|.                       :.|..|::|||.|..:...:....:.|.|||..|.
Mouse   617 QAMMKGS-----------------------HKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLF 658

  Fly   623 GLREASIEVTGEMHELFKDESYIISQCFLLSTSQV----ACSTDSFM---------GYGPVTPRG 674
            .|...| :..|.......:   ::|:.:.|||||:    .|..|...         |:|||...|
Mouse   659 CLYIVS-KYLGVSSPFLAE---VLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADDG 719

  Fly   675 YGCSYNPHPEQIVFC-VSAFYSCEDTSASRYAKSLQDSL 712
            ||.||....|..:|. :|:.||..:|:|.|:...::.:|
Mouse   720 YGVSYMIAGENTMFFHISSKYSSSETNAQRFGNHIRQAL 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	185/658 (28%)
Cpt1b	NP_034078.2	CPT_N	1..46	CDD:293093
		Carn_acyltransf	173..761	CDD:279140	185/658 (28%)
		Coenzyme A binding. /evidence=ECO:0000250	555..567		6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920