Protein Alignment ChAT and Cpt1a

DIOPT Version :9

• Sequence 1: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: XP_011246904.1
• Gene: Cpt1a / 12894
• MGIID: 1098296
• Length: 798
• Species: Mus musculus
• Alignment Length: 685
• Identity: 186/685 - (27%)
• Similarity: 303/685 - (44%)
• Gaps: 138/685 - (20%)

  Fly    82 FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREA 146
            :.|..:||::||||:.:|::.|:.::.|:......:|...|.:.|:.  .:|.:|..||..|...
Mouse   190 YSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEGDFQRMTALAQDFAV--NLGPKLQWYLKLKSWW 252

  Fly   147 EDNWAYYYWLNEMYMDIRIPLPINSN----------PGMVFPPRRFKTVHDVAHFAARLLDGILS 201
            ..|:...:|...:|:..|.|:.:|||          |..:...|...|:|           .||.
Mouse   253 ATNYVSDWWEEYIYLRGRGPIMVNSNYYAMEMLYITPTHIQAARAGNTIH-----------AILL 306

  Fly   202 HREMLDSGEL-PLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVI 265
            :|..:|..|| |:....|   ..|||.||:.||..:.|.||.:.|     :.:.:.| .||:||.
Mouse   307 YRRTVDREELKPIRLLGS---TIPLCSAQWERLFNTSRIPGEETD-----TIQHVKD-SRHIVVY 362

  Fly   266 CRNQMYCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVP----VGLLTAEPRSTWARDREM 326
            .|.:.:.|.|....| .|...|:..|:..:|.|.    ::|.|    :..|||..|..||:.|:.
Mouse   363 HRGRYFKVWLYHDGR-LLRPRELEQQMQQILDDT----SEPQPGEAKLAALTAADRVPWAKCRQT 422

  Fly   327 LQEDERNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSE 391
            .....:|:::|:.:|.|...:.|||      :.:|:....|      :....:.|..::||
Mouse   423 YFARGKNKQSLDAVEKAAFFVTLDE------SEQGYREEDP------EASIDSYAKSLLHG---- 471

  Fly   392 YNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKI--------------YKKIEEHP 442
             ...:|||||::..::..:...|:..|||.::...|..|.|.:              :.|.:::|
Mouse   472 -RCFDRWFDKSITFVVFKNSKIGINAEHSWADAPIVGHLWEYVMATDVFQLGYSEDGHCKGDKNP 535

  Fly   443 DEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSP 507
                     ::|.|.||:|.:..:.|.....:..|.....:|:|.:.:.:.::||..||.|:.||
Mouse   536 ---------NIPKPTRLQWDIPGECQEVIETSLSSASFLANDVDLHSFPFDTFGKGLIKKCRTSP 591

  Fly   508 DVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLES 572
            |.:|||||||||||..|:...|||::.||.|..||.:.:|:.:||:..:..||           .
Mouse   592 DAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCNFVLAM-----------M 645

  Fly   573 DREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHE 637
            |.....|.|...|.|..:.| :.|:|.|:.           |.|||..|..|...|       ..
Mouse   646 DPTTTAEQRFKLFKIACEKH-QHLYRLAMT-----------GAGIDRHLFCLYVVS-------KY 691

  Fly   638 LFKDESY---IISQCFLLSTSQ-----------------VACSTDSFMGYGPVTPRGYGCSYNPH 682
            |..|..:   ::|:.:.|||||                 |:|..    |:|||...|||.||...
Mouse   692 LAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKYPDYVSCGG----GFGPVADDGYGVSYIIV 752

  Fly   683 PEQIV-FCVSAFYSCEDTSASRYAKSL-QDSLDIM 715
            .|..: |.:|:.:|..:|.:.|:.|.| |..:||:
Mouse   753 GENFIHFHISSKFSSPETDSHRFGKHLRQAMMDII 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	185/679 (27%)
Cpt1a	XP_011246904.1	CPT_N	26..71	CDD:374569
		Carn_acyltransf	196..786	CDD:376382	183/676 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920