DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ChAT and CPT1C

DIOPT Version :9

Sequence 1:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	XP_024307116.1	Gene:	CPT1C / 126129	HGNCID:	18540	Length:	836	Species:	Homo sapiens

Alignment Length:	745	Identity:	201/745 - (26%)
Similarity:	315/745 - (42%)	Gaps:	138/745 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FLTHRLSNITPSDTGW---KDSILSIP-KKWLSTAESVDE-----FGFPDTLPKVPVPALDETMA 101
            |..|....:..|..||   ....:|.| |.||:.......     |.:..:||:.|||::.:|:.
Human   120 FTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVR 184

  Fly   102 DYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREAEDNWAYYYWLNEMYMDIRIP 166
            .|:.::.||.:....:.|..|.::|...|  .:.|..||..|.....|:...:|...:|:..|.|
Human   185 KYLESVRPILSDEDFDWTAVLAQEFLRLQ--ASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNP 247

  Fly   167 LPINSNPGMVFPPRRFKTVHDVAHFAAR---LLDGILSHREMLDSGELPLERAASREKN------ 222
            |.:|||..|:    .|..|......|||   .:..:|.:|..|:..|:|..|.....::
Human   248 LMVNSNYYMM----DFLYVTPTPLQAARAGNAVHALLLYRHRLNRQEIPPVRGPQWVRDGGVVLW 308

  Fly   223 ------------------------QPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVV 263
                                    :|||.|||.::..:.|.|||::|  ::   ..|:| .:||.
Human   309 PLGHVGPGRQLTAHGFLQTLLMGMRPLCSAQYEKIFNTTRIPGVQKD--YI---RHLHD-SQHVA 367

  Fly   264 VICRNQMYCVVLQASDRGKLSESEIASQILYVLSD-APCLPAKPVPVGLLTAEPRSTWARDREML 327
            |..|.:.:.:... |....||...:..|...:|.| :|..|.:. .:..|||.||.|||:.|..|
Human   368 VFHRGRFFRMGTH-SRNSLLSPRALEQQFQRILDDPSPACPHEE-HLAALTAAPRGTWAQVRTSL 430

  Fly   328 QEDERNQRNLELIETAQVVLCLD-EPLAGNFNARGFTGATPTVHRAGDRDETNMAHEMIHGGGSE 391
            :......  ||.:|.|...:.|| ||       .|.|...|    |...|.  .||.::.|.|.:
Human   431 KTQAAEA--LEAVEGAAFFVSLDAEP-------AGLTREDP----AASLDA--YAHALLAGRGHD 480

  Fly   392 YNSGNRWFDKTMQLIICTDGTWGLCYEHSCSE------------GIAVVQLLEKIYKKIEEHPDE 444
                 |||||:..||:.::|..||..|||.::            .....||........:.|||.
Human   481 -----RWFDKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDP 540

  Fly   445 DNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDV 509
            .       ||.|:||:|.:..|:....:.|.:......:::|.:|..:..:||:||:.|.:|.|.
Human   541 T-------LPQPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDS 598

  Fly   510 YIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDR 574
            :||:||||||::..|:...|||||.||.||.||.:.:|:.:.||..:.:||
Human   599 FIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAM-------------- 649

  Fly   575 EDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELF 639
            ||:|:         :......|||.||.:...::...:.|.|:|..|..|    ..|:..:|...
Human   650 EDKEK---------TDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFAL----YIVSRFLHLQS 701

  Fly   640 KDESYIISQCFLLSTSQVACS-------------TDSFMGYGPVTPRGYGCSYNPHPE-QIVFCV 690
            ...:.:.|:.:.|||||:...             ..|..|:||....|||.||....: .|.|.:
Human   702 PFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGMITFHI 766

  Fly   691 SAFYSCEDTSASRYAKSLQDSLDIMRDLLQ 720
            |:..|...|.:.|..:.::|:|..:..|.|
Human   767 SSKKSSTKTDSHRLGQHIEDALLDVASLFQ 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	188/688 (27%)
CPT1C	XP_024307116.1	CPT_N	1..46	CDD:318644
CPT1C	XP_024307116.1	Carn_acyltransf	171..788	CDD:307070	187/684 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920